{"id":"https://openalex.org/W1977874170","doi":"https://doi.org/10.1074/jbc.274.36.25594","title":"Differential Localization of 5- and 15-Lipoxygenases to the Nuclear Envelope in RAW Macrophages","display_name":"Differential Localization of 5- and 15-Lipoxygenases to the Nuclear Envelope in RAW Macrophages","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W1977874170","doi":"https://doi.org/10.1074/jbc.274.36.25594","mag":"1977874170","pmid":"https://pubmed.ncbi.nlm.nih.gov/10464294"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.36.25594","doi":"https://doi.org/10.1074/jbc.274.36.25594","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.36.25594","pdf_url":"http://www.jbc.org/article/S0021925819553182/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819553182/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023258176","display_name":"Peter Christmas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Christmas","raw_affiliation_strings":["Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA","From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002371490","display_name":"Justin W. Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin W. Fox","raw_affiliation_strings":["Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086240751","display_name":"Sonia R. Ursino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia R. Ursino","raw_affiliation_strings":["Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085550092","display_name":"Roy Jason Soberman","orcid":"https://orcid.org/0000-0002-2817-0517","observed_orcids":["https://orcid.org/0000-0002-2817-0517"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy J. Soberman","raw_affiliation_strings":["Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Arthritis Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085550092"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.3236,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.77168732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"274","issue":"36","first_page":"25594","last_page":"25598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":1.0},{"id":"https://openalex.org/keywords/nuclear-envelope-localization","display_name":"nuclear envelope localization","score":0.8320000171661377},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9110000133514404},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/15-s-hydroxyeicosatetraenoic-acid","display_name":"15(S)-hydroxyeicosatetraenoic acid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/subcellular-compartmentalization","display_name":"subcellular compartmentalization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-translocation","display_name":"protein translocation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.8659999966621399},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8320000171661377},{"id":"https://openalex.org/keywords/monocytes-macrophages","display_name":"monocytes/macrophages","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.737858772277832},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6696629524230957},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.6302381157875061},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5915239453315735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46406516432762146},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.42797282338142395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41207632422447205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3520508110523224},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07062289118766785}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001094","descriptor_name":"Arachidonate 5-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.36.25594","doi":"https://doi.org/10.1074/jbc.274.36.25594","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.36.25594","pdf_url":"http://www.jbc.org/article/S0021925819553182/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10464294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10464294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.36.25594","doi":"https://doi.org/10.1074/jbc.274.36.25594","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.36.25594","pdf_url":"http://www.jbc.org/article/S0021925819553182/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4587398558","display_name":null,"funder_award_id":"R01ES-50859","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8181590737","display_name":"CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE","funder_award_id":"P01DK038452","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000895811","display_name":"Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital","funder_award_id":"P30DK043351","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977874170.pdf","grobid_xml":"https://content.openalex.org/works/W1977874170.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1545327957","https://openalex.org/W1558383070","https://openalex.org/W1562310953","https://openalex.org/W1564614506","https://openalex.org/W1664417331","https://openalex.org/W1833773653","https://openalex.org/W1964942556","https://openalex.org/W1972172786","https://openalex.org/W1975207791","https://openalex.org/W1975304761","https://openalex.org/W1980832959","https://openalex.org/W1981239721","https://openalex.org/W1982407164","https://openalex.org/W1994730705","https://openalex.org/W1994862373","https://openalex.org/W2004704496","https://openalex.org/W2007082033","https://openalex.org/W2008057379","https://openalex.org/W2014768234","https://openalex.org/W2018581089","https://openalex.org/W2023769870","https://openalex.org/W2024176341","https://openalex.org/W2024819037","https://openalex.org/W2026304372","https://openalex.org/W2026546681","https://openalex.org/W2034058468","https://openalex.org/W2038575244","https://openalex.org/W2039376197","https://openalex.org/W2040062751","https://openalex.org/W2041823256","https://openalex.org/W2051271931","https://openalex.org/W2054044627","https://openalex.org/W2064700667","https://openalex.org/W2068882031","https://openalex.org/W2077251970","https://openalex.org/W2091246594","https://openalex.org/W2104512614","https://openalex.org/W2117096460","https://openalex.org/W2120133370","https://openalex.org/W2121737195","https://openalex.org/W2143189287","https://openalex.org/W2143350004","https://openalex.org/W2162832897","https://openalex.org/W2215257582","https://openalex.org/W4250845720"],"related_works":["https://openalex.org/W1963822067","https://openalex.org/W2028849618","https://openalex.org/W2051271931","https://openalex.org/W2143350004","https://openalex.org/W2121737195","https://openalex.org/W2126199519","https://openalex.org/W7098481081","https://openalex.org/W2000825465","https://openalex.org/W58405871","https://openalex.org/W2010117102"],"abstract_inverted_index":{"Leukotriene":[0],"formation":[1],"is":[2],"initiated":[3],"in":[4,10,56,87,131,172],"myeloid":[5],"cells":[6,88],"by":[7,133],"an":[8],"increase":[9],"intracellular":[11],"calcium":[12],"and":[13,32,49],"translocation":[14,146],"of":[15,59,82,95,98,108,118,120,152,162],"5-lipoxygenase":[16,47,64],"from":[17],"the":[18,21,57,67,80,113,153,159,178],"cytoplasm":[19,58],"to":[20,41,66,102,112,125],"nuclear":[22,68,114,144,183],"envelope":[23,69,145,184],"where":[24],"it":[25],"can":[26,78],"utilize":[27],"arachidonic":[28,39],"acid.":[29,43],"Monocyte-":[30],"macrophages":[31],"eosinophils":[33],"also":[34],"express":[35],"15-lipoxygenase,":[36],"which":[37,149],"converts":[38],"acid":[40,86],"15(S)-hydroxyeicosatetraenoic":[42,85],"Enhanced":[44],"green":[45],"fluorescent":[46],"(5-LO)":[48],"15-lipoxygenase":[50],"(15-LO)":[51],"fusion":[52],"proteins":[53],"were":[54,100],"expressed":[55],"RAW":[60],"264.7":[61],"macrophages.":[62],"Only":[63],"translocated":[65],"after":[70],"cell":[71],"stimulation,":[72],"suggesting":[73,174],"that":[74,89,141,175],"differential":[75],"subcellular":[76],"compartmentalization":[77],"regulate":[79],"generation":[81],"leukotrienes":[83],"versus":[84],"possess":[90],"both":[91],"lipoxygenases.":[92],"A":[93],"series":[94],"truncation":[96],"mutants":[97,110],"5-LO":[99],"created":[101],"identify":[103],"putative":[104],"targeting":[105,119,129,167],"domains;":[106],"none":[107],"these":[109],"localized":[111],"envelope.":[115],"The":[116,138],"lack":[117],"15-LO":[121],"was":[122,147],"then":[123],"exploited":[124],"search":[126],"for":[127,182],"specific":[128],"motifs":[130],"5-LO,":[132,173],"creating":[134],"5-LO/15-LO":[135],"chimeric":[136],"molecules.":[137],"only":[139],"chimera":[140],"could":[142,169],"sustain":[143],"one":[148],"involved":[150],"replacement":[151],"N-terminal":[154],"237":[155],"amino":[156],"acids":[157],"with":[158],"corresponding":[160],"segment":[161],"15-LO.":[163],"Significantly,":[164],"no":[165],"discrete":[166],"domain":[168],"be":[170],"identified":[171],"sequences":[176],"throughout":[177],"molecule":[179],"are":[180],"required":[181],"localization.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
