{"id":"https://openalex.org/W1977873552","doi":"https://doi.org/10.1021/bi300928u","title":"Active Site Loop Dynamics of a Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis","display_name":"Active Site Loop Dynamics of a Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis","publication_year":2013,"publication_date":"2013-01-09","ids":{"openalex":"https://openalex.org/W1977873552","doi":"https://doi.org/10.1021/bi300928u","mag":"1977873552","pmid":"https://pubmed.ncbi.nlm.nih.gov/23298222","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170518"},"language":"en","primary_location":{"id":"doi:10.1021/bi300928u","doi":"https://doi.org/10.1021/bi300928u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi300928u","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047964465","display_name":"Scott D. Pegan","orcid":"https://orcid.org/0000-0002-2958-5319","observed_orcids":["https://orcid.org/0000-0002-2958-5319"]},"institutions":[{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I2802907415","display_name":"Roosevelt Institute","ror":"https://ror.org/03mf58h04","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802907415"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott D. Pegan","raw_affiliation_strings":["Eleanor Roosevelt Institute and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eleanor Roosevelt Institute and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I2802907415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028385117","display_name":"Kamolchanok Rukseree","orcid":"https://orcid.org/0000-0002-6049-3463","observed_orcids":["https://orcid.org/0000-0002-6049-3463"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4405269862","display_name":"Thailand Science Park","ror":"https://ror.org/05fntp585","country_code":"TH","type":"facility","lineage":["https://openalex.org/I4405269862"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Kamolchanok Rukseree","raw_affiliation_strings":["Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","National Center for Genetic Engineering and Biotechnology (BIOTEC),\rNSTDA, Thailand Science Park, Tha Khlong 12120, Thailand","Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States","National Center for Genetic Engineering and Biotechnology (BIOTEC),#R#NSTDA, Thailand Science Park, Tha Khlong 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology (BIOTEC),\rNSTDA, Thailand Science Park, Tha Khlong 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4405269862","https://openalex.org/I902798049"]},{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology (BIOTEC),#R#NSTDA, Thailand Science Park, Tha Khlong 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4405269862","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038701845","display_name":"Glenn C. Capodagli","orcid":"https://orcid.org/0000-0002-0227-4529","observed_orcids":["https://orcid.org/0000-0002-0227-4529"]},"institutions":[{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I2802907415","display_name":"Roosevelt Institute","ror":"https://ror.org/03mf58h04","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802907415"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn C. Capodagli","raw_affiliation_strings":["Eleanor Roosevelt Institute\rand Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","Eleanor Roosevelt Institute#R#and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eleanor Roosevelt Institute\rand Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I2802907415"]},{"raw_affiliation_string":"Eleanor Roosevelt Institute#R#and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I2802907415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051549358","display_name":"Erica A. Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]},{"id":"https://openalex.org/I2802907415","display_name":"Roosevelt Institute","ror":"https://ror.org/03mf58h04","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802907415"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica A. Baker","raw_affiliation_strings":["Eleanor Roosevelt Institute\rand Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","Eleanor Roosevelt Institute#R#and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eleanor Roosevelt Institute\rand Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I2802907415"]},{"raw_affiliation_string":"Eleanor Roosevelt Institute#R#and Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States","institution_ids":["https://openalex.org/I131651094","https://openalex.org/I2802907415"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Olga Krasnykh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Krasnykh","raw_affiliation_strings":["Department\rof Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois\r60607, United States","Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois\r60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052465031","display_name":"Scott Gary Franzblau","orcid":"https://orcid.org/0000-0002-8698-0243","observed_orcids":["https://orcid.org/0000-0002-8698-0243"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott G. Franzblau","raw_affiliation_strings":["Department\rof Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois\r60607, United States","Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois\r60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois\r60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Tuberculosis Research, University of Illinois at Chicago, Chicago, Illinois#R#60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010165126","display_name":"Andrew D. Mesecar","orcid":"https://orcid.org/0000-0002-1241-2577","observed_orcids":["https://orcid.org/0000-0002-1241-2577"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]},{"id":"https://openalex.org/I4390039259","display_name":"Purdue University Institute for Cancer Research","ror":"https://ror.org/0371gg960","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew D. Mesecar","raw_affiliation_strings":["Departments\rof Biological Sciences\rand Chemistry and Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United\rStates","Departments#R#of Biological Sciences#R#and Chemistry and Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United#R#States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments\rof Biological Sciences\rand Chemistry and Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United\rStates","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]},{"raw_affiliation_string":"Departments#R#of Biological Sciences#R#and Chemistry and Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United#R#States","institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4390039259"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010165126","https://openalex.org/A5047964465"],"corresponding_institution_ids":["https://openalex.org/I131651094","https://openalex.org/I219193219","https://openalex.org/I2802907415","https://openalex.org/I4390039259"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.56,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8113255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"5","first_page":"912","last_page":"925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/active-site-loop","display_name":"active site loop","score":0.8190000057220459},{"id":"https://openalex.org/keywords/zinc-catalysis","display_name":"zinc catalysis","score":0.6299999952316284},{"id":"https://openalex.org/keywords/enzyme-inhibitor-complex","display_name":"enzyme-inhibitor complex","score":0.7549999952316284},{"id":"https://openalex.org/keywords/loop-flexibility","display_name":"loop flexibility","score":0.48399999737739563},{"id":"https://openalex.org/keywords/solvent-isotope-effect","display_name":"solvent isotope effect","score":0.8119999766349792},{"id":"https://openalex.org/keywords/holoenzyme-structure","display_name":"holoenzyme structure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.7280243635177612},{"id":"https://openalex.org/C28165981","wikidata":"https://www.wikidata.org/wiki/Q5255119","display_name":"Aldolase A","level":3,"score":0.7210042476654053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6261520385742188},{"id":"https://openalex.org/C2780866112","wikidata":"https://www.wikidata.org/wiki/Q416915","display_name":"Dihydroxyacetone phosphate","level":3,"score":0.6257825493812561},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.5493584871292114},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5084299445152283},{"id":"https://openalex.org/C118629725","wikidata":"https://www.wikidata.org/wiki/Q2686738","display_name":"Deprotonation","level":3,"score":0.5056746006011963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3845274746417999},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27849721908569336},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11888524889945984},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004099","descriptor_name":"Dihydroxyacetone Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi300928u","doi":"https://doi.org/10.1021/bi300928u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi300928u","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:23298222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23298222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3139815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4170518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3139815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170518","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5341518688","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA023168","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7704041689","display_name":"Assessment of deubiquitinating and deISGylating activity; specificity motifs amon","funder_award_id":"R03AI092249","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1486848466","https://openalex.org/W1506579504","https://openalex.org/W1539796472","https://openalex.org/W1966200849","https://openalex.org/W1971442785","https://openalex.org/W1977222497","https://openalex.org/W1988161739","https://openalex.org/W1988261502","https://openalex.org/W2001641653","https://openalex.org/W2004104176","https://openalex.org/W2005794526","https://openalex.org/W2005986251","https://openalex.org/W2022189389","https://openalex.org/W2022578820","https://openalex.org/W2036570431","https://openalex.org/W2039232918","https://openalex.org/W2043047584","https://openalex.org/W2048322679","https://openalex.org/W2049315300","https://openalex.org/W2052206534","https://openalex.org/W2062795895","https://openalex.org/W2081436285","https://openalex.org/W2089411617","https://openalex.org/W2090808271","https://openalex.org/W2098732312","https://openalex.org/W2111967267","https://openalex.org/W2116216369","https://openalex.org/W2137844167","https://openalex.org/W2146538795","https://openalex.org/W2148333082","https://openalex.org/W2148386309","https://openalex.org/W2180229411","https://openalex.org/W2282054059","https://openalex.org/W2297786506","https://openalex.org/W2323630730","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2090808271","https://openalex.org/W589677075","https://openalex.org/W2772037046","https://openalex.org/W2792868188","https://openalex.org/W2541893144","https://openalex.org/W3174207903","https://openalex.org/W4381839229","https://openalex.org/W7171386594","https://openalex.org/W2040385646","https://openalex.org/W4294755263"],"abstract_inverted_index":{"Class":[0],"II":[1,32,59,86,117,130],"fructose":[2,48],"1,6-bisphosphate":[3],"aldolases":[4],"(FBAs,":[5],"EC":[6],"4.1.2.13)":[7],"comprise":[8],"one":[9],"of":[10,13,16,26,47,84,101,112,138,144,152,175,184,198,213,234,246],"two":[11],"families":[12],"aldolases.":[14],"Instead":[15],"forming":[17,50],"a":[18,27,38,136,179,196,209],"Schiff":[19],"base":[20],"intermediate":[21,41],"using":[22],"an":[23],"\u03b5-amino":[24],"group":[25],"lysine":[28],"side":[29],"chain,":[30],"class":[31,58,85,116,129],"FBAs":[33,60,87,118],"utilize":[34],"Zn(II)":[35],"to":[36,64,156,163,230],"stabilize":[37],"proposed":[39],"hydroxyenolate":[40],"(HEI)":[42],"in":[43,67,178,248],"the":[44,99,102,109,113,127,139,145,149,153,169,201,214,232,244],"reversible":[45],"cleavage":[46],"1,6-bisphosphate,":[49],"glyceraldehyde":[51],"3-phosphate":[52],"and":[53,94,141,147,188,191,224],"dihydroxyacetone":[54],"phosphate":[55],"(DHAP).":[56],"As":[57],"have":[61,96],"been":[62,72,97,122],"shown":[63],"be":[65],"essential":[66],"pathogenic":[68],"bacteria,":[69,93],"focus":[70],"has":[71,119],"placed":[73],"on":[74,195,222,237],"these":[75],"enzymes":[76],"as":[77,135],"potential":[78],"antibacterial":[79],"targets.":[80],"Although":[81],"structural":[82,186],"studies":[83,193],"from":[88],"Mycobacterium":[89],"tuberculosis":[90],"(MtFBA),":[91],"other":[92],"protozoa":[95],"reported,":[98],"structure":[100,151,245],"active":[103,172,202],"site":[104,173,203],"loop":[105,174,204,235],"responsible":[106],"for":[107,115,168],"catalyzing":[108],"protonation-deprotonation":[110],"steps":[111],"reaction":[114,216],"not":[120],"yet":[121],"observed.":[123],"We":[124],"therefore":[125],"utilized":[126],"potent":[128],"FBA":[131],"inhibitor":[132],"phosphoglycolohydroxamate":[133],"(PGH)":[134],"mimic":[137],"HEI-":[140],"DHAP-bound":[142],"form":[143],"enzyme":[146],"determined":[148],"X-ray":[150],"MtFBA-PGH":[154],"complex":[155],"1.58":[157],"\u00c5.":[158],"Remarkably,":[159],"we":[160,241],"are":[161],"able":[162],"observe":[164],"well-defined":[165],"electron":[166],"density":[167],"previously":[170],"elusive":[171],"MtFBA":[176,215,223,247],"trapped":[177],"catalytically":[180,225],"competent":[181],"orientation.":[182],"Utilization":[183],"this":[185],"information":[187],"site-directed":[189],"mutagenesis":[190],"kinetic":[192],"conducted":[194],"series":[197],"residues":[199],"within":[200],"revealed":[205],"that":[206],"E169":[207],"facilitates":[208],"water-mediated":[210],"deprotonation-protonation":[211],"step":[212],"mechanism.":[217],"Also,":[218],"solvent":[219],"isotope":[220],"effects":[221],"relevant":[226],"mutants":[227],"were":[228],"used":[229],"probe":[231],"effect":[233],"flexibility":[236],"catalytic":[238],"efficiency.":[239],"Additionally,":[240],"also":[242],"reveal":[243],"its":[249],"holoenzyme":[250],"form.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
