{"id":"https://openalex.org/W1977731998","doi":"https://doi.org/10.1002/jso.2930590111","title":"Prognostic factors of resectable intrahepatic cholangiocarcinoma","display_name":"Prognostic factors of resectable intrahepatic cholangiocarcinoma","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W1977731998","doi":"https://doi.org/10.1002/jso.2930590111","mag":"1977731998","pmid":"https://pubmed.ncbi.nlm.nih.gov/7745976"},"language":"en","primary_location":{"id":"doi:10.1002/jso.2930590111","doi":"https://doi.org/10.1002/jso.2930590111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.2930590111","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084762687","display_name":"Fong\u2010Fu Chou","orcid":"https://orcid.org/0000-0001-5635-1684","observed_orcids":["https://orcid.org/0000-0001-5635-1684"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Fong\u2010Fu Chou","raw_affiliation_strings":["Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037664275","display_name":"Shyr\u2010Ming Sheen\u2010Chen","orcid":"https://orcid.org/0000-0002-6204-3706","observed_orcids":["https://orcid.org/0000-0002-6204-3706"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shyr\u2010Ming Sheen\u2010Chen","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419576","display_name":"Chao\u2010Long Chen","orcid":"https://orcid.org/0000-0003-0566-9312","observed_orcids":["https://orcid.org/0000-0003-0566-9312"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chao\u2010Long Chen","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043667324","display_name":"Yaw\u2010Sen Chen","orcid":"https://orcid.org/0000-0001-8498-3830","observed_orcids":["https://orcid.org/0000-0001-8498-3830"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yaw\u2010Sen Chen","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108395004","display_name":"Mao\u2010Chan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mao\u2010Chan Chen","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084762687"],"corresponding_institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093821"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":4.1821,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.93331077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"59","issue":"1","first_page":"40","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/resectable-liver-cancer","display_name":"resectable liver cancer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hla-dr-expression","display_name":"HLA-DR expression","score":0.847000002861023},{"id":"https://openalex.org/keywords/hilar-lymph-node-metastasis","display_name":"hilar lymph node metastasis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.6460000276565552},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9242537021636963},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.6688998937606812},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6438173651695251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.588115930557251},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.5704526305198669},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.524678647518158},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.4444712996482849},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42434561252593994},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.41276639699935913},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3588172197341919},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33594757318496704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21132764220237732}],"mesh":[{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jso.2930590111","doi":"https://doi.org/10.1002/jso.2930590111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.2930590111","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:7745976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7745976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W207256397","https://openalex.org/W1902258135","https://openalex.org/W1993009281","https://openalex.org/W2010867882","https://openalex.org/W2026716789","https://openalex.org/W2031585280","https://openalex.org/W2096428903","https://openalex.org/W2290596859","https://openalex.org/W2323593222","https://openalex.org/W2413113862","https://openalex.org/W2419117039","https://openalex.org/W4254941419"],"related_works":["https://openalex.org/W2280877577","https://openalex.org/W37553126","https://openalex.org/W2026716789","https://openalex.org/W4384942228","https://openalex.org/W2583107525","https://openalex.org/W2501808695","https://openalex.org/W2040303018","https://openalex.org/W1999437680","https://openalex.org/W2998399835","https://openalex.org/W2264791367"],"abstract_inverted_index":{"Intrahepatic":[0],"cholangiocarcinoma":[1,11,23],"is":[2],"a":[3,71,74,78,139,162,182],"rare":[4],"disease.":[5],"The":[6,33,43,133],"prognostic":[7,184],"factors":[8,28,62],"of":[9,127,130,169],"resectable":[10,22],"have":[12],"not":[13],"been":[14],"previously":[15],"reported.":[16],"Nineteen":[17],"patients":[18,106,168],"(10M,":[19],"9F)":[20],"with":[21,70,94,107,138,188],"were":[24,61,86],"investigated":[25],"to":[26,48],"find":[27],"that":[29,63,186],"might":[30],"influence":[31,66],"prognosis.":[32,68],"cumulative":[34],"survival":[35],"rate":[36],"was":[37,46,123,146,161,181],"measured":[38],"using":[39],"the":[40,90,149,189],"Kaplan-Meier":[41],"method.":[42],"log-rank":[44],"test":[45],"used":[47],"compare":[49],"two":[50],"survivals.":[51],"Age,":[52],"sex,":[53],"tumor":[54,121],"size,":[55],"and":[56,77,151],"positive":[57,72,95,108,134,150,157,170],"tissue":[58],"carcinoembryonic":[59],"antigen":[60],"had":[64,82,99,110],"no":[65,143],"on":[67,120],"Patients":[69,93],"HLA-DR,":[73],"well-differentiated":[75],"carcinoma,":[76],"clear":[79],"resective":[80],"margin":[81],"better":[83,140],"prognoses":[84,101,112],"but":[85,142],"statistically":[87],"undifferentiatable":[88],"from":[89],"other":[91],"patients.":[92],"hilar":[96,158],"lymph":[97,159,171],"nodes":[98],"poor":[100],"(P":[102,113],"<":[103,114],"0.01),":[104],"whereas":[105],"mucobilia":[109,180],"good":[111,183],"0.05).":[115],"Positive":[116,179],"staining":[117,136,154],"for":[118],"HLA-DR":[119,135,153],"cells":[122],"observed":[124],"in":[125],"nine":[126],"19":[128],"cases":[129],"intrahepatic":[131],"cholangiocarcinoma.":[132],"correlated":[137,187],"prognosis,":[141],"significant":[144],"difference":[145],"noted":[147],"between":[148],"negative":[152],"group.":[155],"A":[156],"node":[160,172],"grave":[163],"sign,":[164],"as":[165],"almost":[166],"all":[167],"died":[173],"within":[174],"9":[175],"months":[176],"after":[177],"operation.":[178],"sign":[185],"long-term":[190],"survival.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}