{"id":"https://openalex.org/W1977709595","doi":"https://doi.org/10.1371/journal.pone.0045811","title":"Synergism and Rules from Combination of Baicalin, Jasminoidin and Desoxycholic acid in Refined Qing Kai Ling for Treat Ischemic Stroke Mice Model","display_name":"Synergism and Rules from Combination of Baicalin, Jasminoidin and Desoxycholic acid in Refined Qing Kai Ling for Treat Ischemic Stroke Mice Model","publication_year":2012,"publication_date":"2012-09-26","ids":{"openalex":"https://openalex.org/W1977709595","doi":"https://doi.org/10.1371/journal.pone.0045811","mag":"1977709595","pmid":"https://pubmed.ncbi.nlm.nih.gov/23049867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3458908"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0045811","doi":"https://doi.org/10.1371/journal.pone.0045811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0045811","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045811&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045811&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402504","display_name":"Jian Li","orcid":"https://orcid.org/0000-0002-4549-0694","observed_orcids":["https://orcid.org/0000-0002-4549-0694","https://orcid.org/0009-0003-1807-4366"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082410935","display_name":"Runguo Wu","orcid":"https://orcid.org/0000-0002-6523-5754","observed_orcids":["https://orcid.org/0000-0002-6523-5754"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4391768142","display_name":"State Key Laboratory of Cognitive Neuroscience and Learning","ror":"https://ror.org/059y0zb32","country_code":"CN","type":"facility","lineage":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Run-guo Wu","raw_affiliation_strings":["State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018149833","display_name":"Fanyun Meng","orcid":"https://orcid.org/0000-0002-3982-044X","observed_orcids":["https://orcid.org/0000-0002-3982-044X"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan-yun Meng","raw_affiliation_strings":["School of Resources Science & Technology, Beijing Normal University, Beijing, China","School of Resources Science and Technology, Beijing Normal University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Resources Science & Technology, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941"]},{"raw_affiliation_string":"School of Resources Science and Technology, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435265","display_name":"Zhong Wang","orcid":"https://orcid.org/0000-0002-0498-0435","observed_orcids":["https://orcid.org/0000-0002-0498-0435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong Wang","raw_affiliation_strings":["Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767545","display_name":"Changming Wang","orcid":"https://orcid.org/0000-0002-8632-7666","observed_orcids":["https://orcid.org/0000-0002-8632-7666"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4391768142","display_name":"State Key Laboratory of Cognitive Neuroscience and Learning","ror":"https://ror.org/059y0zb32","country_code":"CN","type":"facility","lineage":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-ming Wang","raw_affiliation_strings":["State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101684330","display_name":"Yongyan Wang","orcid":"https://orcid.org/0000-0001-8900-4689","observed_orcids":["https://orcid.org/0000-0001-8900-4689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-yan Wang","raw_affiliation_strings":["Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088766936","display_name":"Zhanjun Zhang","orcid":"https://orcid.org/0000-0001-7266-4218","observed_orcids":["https://orcid.org/0000-0001-7266-4218"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4391768142","display_name":"State Key Laboratory of Cognitive Neuroscience and Learning","ror":"https://ror.org/059y0zb32","country_code":"CN","type":"facility","lineage":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhan-jun Zhang","raw_affiliation_strings":["State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China","institution_ids":["https://openalex.org/I25254941","https://openalex.org/I4391768142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088766936"],"corresponding_institution_ids":["https://openalex.org/I25254941","https://openalex.org/I4391768142"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.2326,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90367898,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"9","first_page":"e45811","last_page":"e45811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.22669999301433563,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8050000071525574},{"id":"https://openalex.org/keywords/baicalin","display_name":"baicalin","score":0.8399999737739563},{"id":"https://openalex.org/keywords/jasminoidin","display_name":"jasminoidin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9440000057220459},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/drug-target-interaction-networks","display_name":"drug-target network","score":0.7770000100135803},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2780113650","wikidata":"https://www.wikidata.org/wiki/Q2879368","display_name":"Baicalin","level":3,"score":0.923629879951477},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.6189659833908081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5996607542037964},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5194858312606812},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4902952015399933},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44263768196105957},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.43875983357429504},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4260900020599365},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35970014333724976},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3103456497192383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2816668152809143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27601101994514465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23546600341796875},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20969057083129883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14217963814735413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13053631782531738},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11982932686805725},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0801953673362732},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039823","descriptor_name":"Iridoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0045811","doi":"https://doi.org/10.1371/journal.pone.0045811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0045811","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045811&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:23049867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23049867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3458908","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3458908/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.3556","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.3556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/36/8f/pone.0045811.PMC3458908.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0045811","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045811","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2d50630e1b55424c9e80554d63ec9e23","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2d50630e1b55424c9e80554d63ec9e23","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 9, p e45811 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/119548","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Synergism_and_Rules_from_Combination_of_Baicalin_Jasminoidin_and_Desoxycholic_acid_in_Refined_Qing_Kai_Ling_for_Treat_Ischemic_Stroke_Mice_Model/119548","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/73699","doi":null,"is_oa":true,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/73699","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0045811","doi":"https://doi.org/10.1371/journal.pone.0045811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0045811","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045811&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2106239457","display_name":null,"funder_award_id":"NCET-10","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G3022541996","display_name":null,"funder_award_id":"NCET-10-0249","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"}],"funders":[{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977709595.pdf","grobid_xml":"https://content.openalex.org/works/W1977709595.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W34241904","https://openalex.org/W122914384","https://openalex.org/W206263908","https://openalex.org/W273100156","https://openalex.org/W1592483428","https://openalex.org/W1677040403","https://openalex.org/W1702807246","https://openalex.org/W1884792319","https://openalex.org/W1966149946","https://openalex.org/W1968305129","https://openalex.org/W1972599573","https://openalex.org/W1974360884","https://openalex.org/W1975060060","https://openalex.org/W1983612328","https://openalex.org/W1986234964","https://openalex.org/W1987595468","https://openalex.org/W1992662280","https://openalex.org/W1994298894","https://openalex.org/W1995807591","https://openalex.org/W1999281311","https://openalex.org/W2000425613","https://openalex.org/W2003302931","https://openalex.org/W2021199020","https://openalex.org/W2022686947","https://openalex.org/W2028034679","https://openalex.org/W2040957577","https://openalex.org/W2053123263","https://openalex.org/W2054364659","https://openalex.org/W2055794524","https://openalex.org/W2056164078","https://openalex.org/W2059391512","https://openalex.org/W2070050882","https://openalex.org/W2070996331","https://openalex.org/W2071479387","https://openalex.org/W2072523093","https://openalex.org/W2075104267","https://openalex.org/W2086421390","https://openalex.org/W2088436698","https://openalex.org/W2089430412","https://openalex.org/W2092154231","https://openalex.org/W2096037514","https://openalex.org/W2100561602","https://openalex.org/W2107543261","https://openalex.org/W2113551867","https://openalex.org/W2124911115","https://openalex.org/W2125683177","https://openalex.org/W2128380808","https://openalex.org/W2132406600","https://openalex.org/W2133199783","https://openalex.org/W2135163571","https://openalex.org/W2140595402","https://openalex.org/W2141744801","https://openalex.org/W2144669624","https://openalex.org/W2158277781","https://openalex.org/W2163524475","https://openalex.org/W2284464238","https://openalex.org/W2363706886","https://openalex.org/W2369515627","https://openalex.org/W2411316343","https://openalex.org/W2412191703","https://openalex.org/W2466241842","https://openalex.org/W4313422295"],"related_works":["https://openalex.org/W7098263224","https://openalex.org/W2351773781","https://openalex.org/W3022109193","https://openalex.org/W2001911649","https://openalex.org/W2362461046","https://openalex.org/W4282921052","https://openalex.org/W4404651772","https://openalex.org/W3081218830","https://openalex.org/W4285591839","https://openalex.org/W4224079488"],"abstract_inverted_index":{"Refined":[0],"Qing-Kai-Ling":[1],"(QKL),":[2],"a":[3,18,73,84,181,199],"modified":[4],"Chinese":[5,214],"medicine,":[6],"consists":[7],"of":[8,24,28,34,52,54,65,80,93,113,209,212,229,236,239,257],"three":[9,81],"main":[10],"ingredients":[11],"(Baicalin,":[12],"Jasminoidin":[13,175],"and":[14,37,57,69,103,144],"Desoxycholic":[15,58,185],"acid),":[16],"plays":[17],"synergistic":[19],"effect":[20,87],"on":[21,43,88,155],"the":[22,25,32,35,44,63,78,110,136,156,159,169,173,188,207,226,254],"treatment":[23],"acute":[26],"stage":[27],"ischemic":[29,45,89],"stroke.":[30],"However,":[31],"rules":[33],"combination":[36,53,79,237],"synergism":[38],"are":[39],"still":[40],"unknown.":[41],"Based":[42],"stroke":[46,90],"mice":[47],"model,":[48],"all":[49],"different":[50],"kinds":[51],"Baicalin,":[55],"Jasminoidin,":[56],"acid":[59,186],"were":[60,146,204],"investigated":[61],"by":[62],"methods":[64],"neurological":[66],"examination,":[67],"microarray,":[68],"genomics":[70],"analysis.":[71,150],"As":[72],"result,":[74],"it":[75],"confirmed":[76],"that":[77,123,162,167,179,197,245],"drugs":[82],"offered":[83],"better":[85],"therapeutical":[86],"than":[91,132],"monotherapy":[92],"each":[94],"drug.":[95],"Additionally,":[96],"we":[97,152,220],"used":[98],"Ingenuity":[99],"pathway":[100],"Analysis":[101],"(IPA)":[102],"principal":[104,125],"component":[105],"analysis":[106],"(PCA)":[107],"to":[108,225,252],"extract":[109],"dominant":[111],"information":[112],"expression":[114],"changes":[115],"in":[116,135,172],"373":[117],"ischemia-related":[118],"genes.":[119],"The":[120],"results":[121],"suggested":[122],"5":[124],"components":[126],"(PC1-5)":[127],"could":[128,193],"account":[129],"for":[130],"more":[131],"95%":[133],"energy":[134],"gene":[137],"data.":[138],"Moreover,":[139],"3":[140],"clusters":[141],"(PC1,":[142],"PC2+PC5,":[143],"PC3+PC4)":[145],"addressed":[147],"with":[148,165,177,195,206],"cluster":[149],"Furthermore,":[151],"matched":[153],"PCs":[154],"drug-target":[157],"networks,":[158],"findings":[160],"demonstrated":[161],"Baicalin":[163],"related":[164,176],"PC1":[166],"played":[168,180,198],"leading":[170],"role":[171],"combination;":[174],"PC2+PC5":[178],"compensatory":[182],"role;":[183],"while":[184],"had":[187],"least":[189],"performance":[190],"alone":[191],"which":[192],"relate":[194],"PC3+PC4":[196],"compatible":[200],"role.":[201],"These":[202],"manifestations":[203],"accorded":[205],"principle":[208],"herbal":[210],"formulae":[211],"Traditional":[213],"Medicine":[215],"(TCM),":[216],"emperor-minister-adjuvant-courier.":[217],"In":[218],"conclusion,":[219],"firstly":[221],"provided":[222],"scientific":[223],"evidence":[224],"classic":[227],"theory":[228],"TCM":[230],"formulae,":[231],"an":[232,249],"initiating":[233],"holistic":[234],"viewpoint":[235],"therapy":[238],"TCM.":[240],"This":[241],"study":[242],"also":[243],"illustrated":[244],"PCA":[246],"might":[247],"be":[248],"applicable":[250],"method":[251],"analyze":[253],"complicated":[255],"data":[256],"drug":[258],"combination.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}