{"id":"https://openalex.org/W1977685190","doi":"https://doi.org/10.1016/j.semcdb.2008.11.016","title":"Specification and loss of melanocyte stem cells","display_name":"Specification and loss of melanocyte stem cells","publication_year":2008,"publication_date":"2008-12-14","ids":{"openalex":"https://openalex.org/W1977685190","doi":"https://doi.org/10.1016/j.semcdb.2008.11.016","mag":"1977685190","pmid":"https://pubmed.ncbi.nlm.nih.gov/19124082"},"language":"en","primary_location":{"id":"doi:10.1016/j.semcdb.2008.11.016","doi":"https://doi.org/10.1016/j.semcdb.2008.11.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2008.11.016","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell & Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041789433","display_name":"Kathleen C. Robinson","orcid":"https://orcid.org/0000-0001-9452-5323","observed_orcids":["https://orcid.org/0000-0001-9452-5323"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen C. Robinson","raw_affiliation_strings":["Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078874539","display_name":"David E. Fisher","orcid":"https://orcid.org/0000-0002-5506-0575","observed_orcids":["https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E. Fisher","raw_affiliation_strings":["Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078874539"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":0.1684,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.11447811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"111","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.24169999361038208,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocyte-stem-cells","display_name":"melanocyte stem cells","score":1.0},{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.9700000286102295},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.8130000233650208},{"id":"https://openalex.org/keywords/stem-cell-specification","display_name":"stem cell specification","score":0.8450000286102295},{"id":"https://openalex.org/keywords/stem-cell-survival","display_name":"stem cell survival","score":0.7429999709129333},{"id":"https://openalex.org/keywords/melanocyte-differentiation","display_name":"melanocyte differentiation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/melanocyte-lineage","display_name":"melanocyte lineage","score":0.46399998664855957},{"id":"https://openalex.org/keywords/melanocyte-biology","display_name":"melanocyte biology","score":0.7099999785423279},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9166088104248047},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8355328440666199},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.7918291091918945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6521922945976257},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5926108956336975},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.5582060813903809},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.5001566410064697},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.49028852581977844},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4817366898059845},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.47441786527633667},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4371994733810425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3269128203392029},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.28171098232269287},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27554741501808167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25915074348449707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09948241710662842},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.08448973298072815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semcdb.2008.11.016","doi":"https://doi.org/10.1016/j.semcdb.2008.11.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcdb.2008.11.016","pdf_url":null,"source":{"id":"https://openalex.org/S105347553","display_name":"Seminars in Cell and Developmental Biology","issn_l":"1084-9521","issn":["1084-9521","1096-3634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cell & Developmental Biology","raw_type":"journal-article"},{"id":"pmid:19124082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19124082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cell & developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1487917997","https://openalex.org/W1498791370","https://openalex.org/W1667206495","https://openalex.org/W1883936019","https://openalex.org/W1963652662","https://openalex.org/W1967390278","https://openalex.org/W1979420492","https://openalex.org/W1982714302","https://openalex.org/W1994376203","https://openalex.org/W1996545028","https://openalex.org/W1997889534","https://openalex.org/W1999634133","https://openalex.org/W2015009944","https://openalex.org/W2020823827","https://openalex.org/W2021064142","https://openalex.org/W2025147250","https://openalex.org/W2025713011","https://openalex.org/W2032044707","https://openalex.org/W2043730237","https://openalex.org/W2044560586","https://openalex.org/W2048462929","https://openalex.org/W2051718122","https://openalex.org/W2056328828","https://openalex.org/W2061257481","https://openalex.org/W2072277438","https://openalex.org/W2078337982","https://openalex.org/W2078880170","https://openalex.org/W2080559511","https://openalex.org/W2080686146","https://openalex.org/W2080930253","https://openalex.org/W2091478826","https://openalex.org/W2098763910","https://openalex.org/W2106717024","https://openalex.org/W2106771547","https://openalex.org/W2109349283","https://openalex.org/W2113379770","https://openalex.org/W2113531954","https://openalex.org/W2113958528","https://openalex.org/W2118903985","https://openalex.org/W2125842849","https://openalex.org/W2133608451","https://openalex.org/W2137357450","https://openalex.org/W2144200294","https://openalex.org/W2144969564","https://openalex.org/W2145402938","https://openalex.org/W2145765262","https://openalex.org/W2146355396","https://openalex.org/W2147516927","https://openalex.org/W2156266404","https://openalex.org/W2159969192","https://openalex.org/W2161275429","https://openalex.org/W2162851671","https://openalex.org/W2402553014","https://openalex.org/W2609006218"],"related_works":["https://openalex.org/W2418328749","https://openalex.org/W147966540","https://openalex.org/W1638749251","https://openalex.org/W1996132066","https://openalex.org/W2034762012","https://openalex.org/W2288395037","https://openalex.org/W2166613537","https://openalex.org/W2277602068","https://openalex.org/W2904163545","https://openalex.org/W7097210225"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}