{"id":"https://openalex.org/W1977626367","doi":"https://doi.org/10.1097/mpg.0b013e31802b320e","title":"Nonadherence With Thiopurine Immunomodulator and Mesalamine Medications in Children with Crohn Disease","display_name":"Nonadherence With Thiopurine Immunomodulator and Mesalamine Medications in Children with Crohn Disease","publication_year":2007,"publication_date":"2007-01-24","ids":{"openalex":"https://openalex.org/W1977626367","doi":"https://doi.org/10.1097/mpg.0b013e31802b320e","mag":"1977626367","pmid":"https://pubmed.ncbi.nlm.nih.gov/17255828"},"language":"en","primary_location":{"id":"doi:10.1097/mpg.0b013e31802b320e","doi":"https://doi.org/10.1097/mpg.0b013e31802b320e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0b013e31802b320e","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051120488","display_name":"Maria M. Oliva\u2010Hemker","orcid":"https://orcid.org/0000-0002-4054-7372","observed_orcids":["https://orcid.org/0000-0002-4054-7372"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria M Oliva\u2010Hemker","raw_affiliation_strings":["Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051976538","display_name":"Vivian Abadom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivian Abadom","raw_affiliation_strings":["Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044937555","display_name":"Carmen Cuffari","orcid":"https://orcid.org/0000-0003-2810-2319","observed_orcids":["https://orcid.org/0000-0003-2810-2319"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carmen Cuffari","raw_affiliation_strings":["Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Bloomberg School of Public Health Johns Hopkins University School of Medicine Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040895261","display_name":"Richard E. Thompson","orcid":"https://orcid.org/0000-0001-8378-4426","observed_orcids":["https://orcid.org/0000-0001-8378-4426"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E Thompson","raw_affiliation_strings":["Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044937555","https://openalex.org/A5051120488","https://openalex.org/A5051976538"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":5.4801,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.94676007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"2","first_page":"180","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12823","display_name":"Adolescent and Pediatric Healthcare","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medication-non-adherence","display_name":"medication non-adherence","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pediatric-crohn-s-disease","display_name":"pediatric Crohn's disease","score":0.8529999852180481},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":1.0},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/emergency-department-visits","display_name":"emergency department visits","score":0.8939999938011169},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/factors-associated-with-adherence","display_name":"factors associated with adherence","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9820170402526855},{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.9523086547851562},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.7530215978622437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6805983781814575},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5944705605506897},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5452679991722107},{"id":"https://openalex.org/C2777173762","wikidata":"https://www.wikidata.org/wiki/Q418529","display_name":"Mercaptopurine","level":2,"score":0.4586316645145416},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4582926034927368},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4531165063381195},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.4260942041873932},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4156602621078491},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0759253203868866}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016312","descriptor_name":"Treatment Refusal","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mpg.0b013e31802b320e","doi":"https://doi.org/10.1097/mpg.0b013e31802b320e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0b013e31802b320e","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},{"id":"pmid:17255828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17255828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric gastroenterology and nutrition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W10955541","https://openalex.org/W1653242715","https://openalex.org/W1894326311","https://openalex.org/W1969818489","https://openalex.org/W1974610554","https://openalex.org/W1978339383","https://openalex.org/W1992648649","https://openalex.org/W1993880754","https://openalex.org/W2004334734","https://openalex.org/W2015338056","https://openalex.org/W2015625787","https://openalex.org/W2021071759","https://openalex.org/W2023284062","https://openalex.org/W2034900606","https://openalex.org/W2036529637","https://openalex.org/W2036691513","https://openalex.org/W2037368522","https://openalex.org/W2037945988","https://openalex.org/W2057112394","https://openalex.org/W2062369130","https://openalex.org/W2074509533","https://openalex.org/W2089119838","https://openalex.org/W2093909822","https://openalex.org/W2096380782","https://openalex.org/W2113388424","https://openalex.org/W2147907790","https://openalex.org/W2155441883","https://openalex.org/W2158476476","https://openalex.org/W2164099498","https://openalex.org/W2168447258","https://openalex.org/W2255357183","https://openalex.org/W2334366154","https://openalex.org/W2411688247","https://openalex.org/W2416150534","https://openalex.org/W2920836380","https://openalex.org/W4249045763","https://openalex.org/W4292198229"],"related_works":["https://openalex.org/W2007086667","https://openalex.org/W2332088586","https://openalex.org/W3205856656","https://openalex.org/W2312680153","https://openalex.org/W1976802213","https://openalex.org/W4310532604","https://openalex.org/W2333134098","https://openalex.org/W2314117781","https://openalex.org/W2793624797","https://openalex.org/W1991454098"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"assess":[2],"the":[3,79,103,126,138],"prevalence":[4,97],"of":[5,31,76,78,84,98,113,140,160],"adherence":[6,57],"to":[7,16,120,145,171,195],"prescribed":[8,40,80,87,93],"medications":[9],"in":[10,201],"children":[11],"with":[12,21,35,43,177,204,216],"Crohn":[13,36,205],"disease":[14,37,206],"and":[15,68,90,106],"identify":[17],"possible":[18],"factors":[19],"associated":[20,215],"nonadherence.":[22],"PATIENTS":[23],"AND":[24],"METHODS:":[25],"This":[26],"was":[27,70,100,122,165,214],"a":[28,44,53,62,73,141,210],"cross-sectional":[29],"study":[30],"51":[32],"pediatric":[33,202],"patients":[34,85,118,169,203],"who":[38,179],"were":[39,59,86,92,180],"maintenance":[41],"therapy":[42,147,200],"thiopurine":[45,88,104,196],"immunomodulator":[46,197],"(6-mercaptopurine":[47],"or":[48,198],"azathioprine)":[49],"and/or":[50],"mesalamine":[51,121,146,172,199],"during":[52],"180-day":[54],"period.":[55],"Medication":[56],"rates":[58],"calculated":[60],"from":[61],"validated":[63],"formula":[64],"using":[65],"pharmacy":[66],"records,":[67],"nonadherence":[69,99,194],"defined":[71],"as":[72],"refill":[74],"rate":[75],"<80%":[77],"medication.":[81],"Seventy-five":[82],"percent":[83],"immunomodulators":[89,105],"86%":[91],"mesalamine.":[94,109],"RESULTS:":[95],"The":[96,110,157],"50%":[101],"for":[102,108,117,168],"66%":[107],"mean":[111,158],"number":[112,159],"emergency":[114,134],"department":[115,135],"visits":[116,164],"adherent":[119,144,170,182],"significantly":[123,166],"greater":[124,167],"than":[125],"nonadherent":[127],"group":[128],"(P":[129,186],"<":[130,187],"0.0008).":[131],"Having":[132,209],"an":[133],"visit":[136,213],"increased":[137],"chances":[139],"patient":[142],"being":[143,217],"by":[148],">9-fold":[149],"(odds":[150],"ratio,":[151],"9.6;":[152],"95%":[153],"confidence":[154],"interval,":[155],"1.87-52.17).":[156],"total":[161],"health":[162,211],"care":[163,212],"(6.1":[173],"+/-":[174,184],"0.8)":[175],"compared":[176],"those":[178],"not":[181],"(3.0":[183],"0.4)":[185],"0.001).":[188],"CONCLUSIONS:":[189],"These":[190],"findings":[191],"suggest":[192],"that":[193],"is":[207],"common.":[208],"adherent.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}