{"id":"https://openalex.org/W1977601765","doi":"https://doi.org/10.1074/jbc.m309017200","title":"Conservation of Regulatory Function in Calcium-binding Proteins","display_name":"Conservation of Regulatory Function in Calcium-binding Proteins","publication_year":2003,"publication_date":"2003-11-26","ids":{"openalex":"https://openalex.org/W1977601765","doi":"https://doi.org/10.1074/jbc.m309017200","mag":"1977601765","pmid":"https://pubmed.ncbi.nlm.nih.gov/14512421"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m309017200","doi":"https://doi.org/10.1074/jbc.m309017200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309017200","pdf_url":"http://www.jbc.org/article/S002192582075739X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582075739X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011883796","display_name":"Thomas Strahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Strahl","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023236906","display_name":"Birgit Grafelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Grafelmann","raw_affiliation_strings":["Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057209988","display_name":"Jens Dannenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Dannenberg","raw_affiliation_strings":["Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048920959","display_name":"Jeremy W. Thorner","orcid":"https://orcid.org/0000-0002-2583-500X","observed_orcids":["https://orcid.org/0000-0002-2583-500X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Thorner","raw_affiliation_strings":["Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720-3200"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720-3200","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071615457","display_name":"Olaf Pongs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Olaf Pongs","raw_affiliation_strings":["Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0308t Hamburg, Zentrum fu\u0308r Molekulare Neurobiologie, Institut fu\u0308r Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]},{"raw_affiliation_string":"Universit\u00e4t Hamburg, Zentrum f\u00fcr Molekulare Neurobiologie, Institut f\u00fcr Neurale Signalverarbeitung, Falkenried 94, 20251 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071615457"],"corresponding_institution_ids":["https://openalex.org/I159176309"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0371,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.71152106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"278","issue":"49","first_page":"49589","last_page":"49599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.2053000032901764,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.10530000180006027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ncs-1","display_name":"NCS-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-kinase","display_name":"phosphatidylinositol 4-kinase","score":0.925000011920929},{"id":"https://openalex.org/keywords/calcium-binding-proteins","display_name":"calcium-binding proteins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7350000143051147},{"id":"https://openalex.org/keywords/functional-conservation","display_name":"functional conservation","score":0.4950000047683716},{"id":"https://openalex.org/keywords/n-myristoylation","display_name":"N-myristoylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9129999876022339},{"id":"https://openalex.org/keywords/kchip2","display_name":"KChIP2","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.8095300197601318},{"id":"https://openalex.org/C77207865","wikidata":"https://www.wikidata.org/wiki/Q25794","display_name":"Myristoylation","level":3,"score":0.7001493573188782},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6680430769920349},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.632908284664154},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.623872697353363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5349518060684204},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5077744126319885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49697187542915344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4952808916568756},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4790578782558441},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4690437912940979},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4367426335811615},{"id":"https://openalex.org/C42086223","wikidata":"https://www.wikidata.org/wiki/Q24723907","display_name":"EF hand","level":4,"score":0.4244462251663208},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39972034096717834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3270736038684845},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3145933747291565},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.29640400409698486},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2666352391242981},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.20785510540008545},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.19127294421195984},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1511196494102478}],"mesh":[{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019870","descriptor_name":"1-Phosphatidylinositol 4-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051580","descriptor_name":"Neuronal Calcium-Sensor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m309017200","doi":"https://doi.org/10.1074/jbc.m309017200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309017200","pdf_url":"http://www.jbc.org/article/S002192582075739X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:14512421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14512421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m309017200","doi":"https://doi.org/10.1074/jbc.m309017200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309017200","pdf_url":"http://www.jbc.org/article/S002192582075739X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1815730394","display_name":null,"funder_award_id":"GM 21841","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000211449","display_name":null,"funder_award_id":"GM21841","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307627","display_name":"Lowe Syndrome Association","ror":"https://ror.org/02kddrj80"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977601765.pdf","grobid_xml":"https://content.openalex.org/works/W1977601765.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1501088201","https://openalex.org/W1521569676","https://openalex.org/W1538683380","https://openalex.org/W1539836777","https://openalex.org/W1562947759","https://openalex.org/W1568234578","https://openalex.org/W1581444291","https://openalex.org/W1608303629","https://openalex.org/W1625894348","https://openalex.org/W1670420367","https://openalex.org/W1886070575","https://openalex.org/W1964574045","https://openalex.org/W1964738485","https://openalex.org/W1966606704","https://openalex.org/W1975038690","https://openalex.org/W1976480464","https://openalex.org/W1981555814","https://openalex.org/W1982149924","https://openalex.org/W1986557295","https://openalex.org/W1991274132","https://openalex.org/W1998749044","https://openalex.org/W2003190277","https://openalex.org/W2008560589","https://openalex.org/W2022425508","https://openalex.org/W2024940074","https://openalex.org/W2027650186","https://openalex.org/W2031403719","https://openalex.org/W2037140390","https://openalex.org/W2038835746","https://openalex.org/W2043491588","https://openalex.org/W2047724990","https://openalex.org/W2048352597","https://openalex.org/W2051746145","https://openalex.org/W2061768568","https://openalex.org/W2067115148","https://openalex.org/W2069847632","https://openalex.org/W2076801049","https://openalex.org/W2085524881","https://openalex.org/W2086449873","https://openalex.org/W2100837269","https://openalex.org/W2115073295","https://openalex.org/W2127518311","https://openalex.org/W2128635872","https://openalex.org/W2138270253","https://openalex.org/W2149893493","https://openalex.org/W2151123986","https://openalex.org/W2158277781","https://openalex.org/W2161986280","https://openalex.org/W2162692258","https://openalex.org/W2163377635","https://openalex.org/W2170280114","https://openalex.org/W3104178650","https://openalex.org/W4243559800"],"related_works":["https://openalex.org/W1568234578","https://openalex.org/W1991274132","https://openalex.org/W2085524881","https://openalex.org/W2008560589","https://openalex.org/W2031733884","https://openalex.org/W7058198071","https://openalex.org/W1999979220","https://openalex.org/W1976480464","https://openalex.org/W2044984675","https://openalex.org/W638426725"],"abstract_inverted_index":{"Frequenin,":[0],"also":[1,47],"known":[2],"as":[3,169],"neuronal":[4],"calcium":[5],"sensor-1":[6],"(NCS-1),":[7],"is":[8,46,61,128],"an":[9],"N-myristoylated":[10,102],"Ca2+-binding":[11],"protein":[12],"that":[13,33,122,133,145,155,163],"has":[14],"been":[15],"conserved":[16],"in":[17,80,96,126,150,158,165],"both":[18,28,67],"sequence":[19],"and":[20,30,43,69,99,132],"three-dimensional":[21],"fold":[22],"during":[23],"evolution.":[24],"We":[25,142],"demonstrate":[26],"using":[27],"genetic":[29],"biochemical":[31],"approaches":[32],"the":[34,50,55,62,90,114,123,146],"observed":[35],"structural":[36],"conservation":[37],"between":[38],"Saccharomyces":[39],"cerevisiae":[40,160],"frequenin":[41],"(Frq1)":[42],"human":[44,78],"NCS-1":[45,79,100,149],"reflected":[48],"at":[49],"functional":[51],"level.":[52],"In":[53],"yeast,":[54,81],"sole":[56],"essential":[57],"target":[58],"of":[59,77,92,117,139,148,156,171,174],"Frq1":[60,98,157],"phosphatidylinositol":[63,175],"4-kinase":[64],"isoform,":[65],"Pik1;":[66],"FRQ1":[68],"PIK1":[70],"are":[71],"indispensable":[72],"for":[73,106],"cell":[74],"viability.":[75],"Expression":[76],"but":[82],"not":[83],"a":[84,109,129],"close":[85],"relative":[86],"(human":[87],"KChIP2),":[88],"rescues":[89],"inviability":[91],"frq1":[93],"cells.":[94],"Furthermore,":[95],"vitro,":[97],"(either":[101],"or":[103],"unmyristoylated)":[104],"compete":[105],"binding":[107,124],"to":[108,136],"small":[110],"28-residue":[111],"motif":[112],"near":[113],"N":[115],"terminus":[116],"Pik1.":[118],"Site-directed":[119],"mutagenesis":[120],"indicates":[121],"determinant":[125],"Pik1":[127],"hydrophobic":[130],"alpha-helix":[131],"frequenins":[134,164],"bind":[135],"one":[137],"side":[138],"this":[140],"alpha-helix.":[141],"propose,":[143],"therefore,":[144],"function":[147],"mammals":[151],"may":[152,167],"closely":[153],"resemble":[154],"S.":[159],"and,":[161],"hence,":[162],"general":[166],"serve":[168],"regulators":[170],"certain":[172],"isoforms":[173],"4-kinase.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
