{"id":"https://openalex.org/W1977585558","doi":"https://doi.org/10.1097/mpg.0b013e3181709464","title":"Drug\u2010related Hepatotoxicity and Acute Liver Failure","display_name":"Drug\u2010related Hepatotoxicity and Acute Liver Failure","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W1977585558","doi":"https://doi.org/10.1097/mpg.0b013e3181709464","mag":"1977585558","pmid":"https://pubmed.ncbi.nlm.nih.gov/18852631"},"language":"en","primary_location":{"id":"doi:10.1097/mpg.0b013e3181709464","doi":"https://doi.org/10.1097/mpg.0b013e3181709464","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0b013e3181709464","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103061016","display_name":"Karen F. Murray","orcid":"https://orcid.org/0000-0001-9898-1430","observed_orcids":["https://orcid.org/0000-0001-9898-1430"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karen F Murray","raw_affiliation_strings":["Hepatobiliary Program, Division of Gastroenterology and Nutrition, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatobiliary Program, Division of Gastroenterology and Nutrition, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067392447","display_name":"Nedim Had\u017ei\u0107","orcid":"https://orcid.org/0000-0002-5493-3418","observed_orcids":["https://orcid.org/0000-0002-5493-3418"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nedim Hadzic","raw_affiliation_strings":["Department of Child Health/Institute of Liver Studies, King's College Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child Health/Institute of Liver Studies, King's College Hospital, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025413690","display_name":"Stefan Wirth","orcid":"https://orcid.org/0000-0003-4576-3987","observed_orcids":["https://orcid.org/0000-0003-4576-3987"]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Wirth","raw_affiliation_strings":["HELIOS Klinikum, Children's Hospital, Witten/Herdecke University, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HELIOS Klinikum, Children's Hospital, Witten/Herdecke University, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060734873","display_name":"Mikelle D. Bassett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikelle Bassett","raw_affiliation_strings":["Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, UK","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006405927","display_name":"Deirdre Anne Kelly","orcid":"https://orcid.org/0000-0001-9776-4354","observed_orcids":["https://orcid.org/0000-0001-9776-4354","https://orcid.org/0009-0007-8098-7966"]},"institutions":[{"id":"https://openalex.org/I4210100347","display_name":"Birmingham Children's Hospital","ror":"https://ror.org/017k80q27","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210100347","https://openalex.org/I4210155225"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deirdre Kelly","raw_affiliation_strings":["Department of Paediatric Hepatology, Birmingham Children's Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Hepatology, Birmingham Children's Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I4210100347"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103061016"],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.6112,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.82129278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"47","issue":"4","first_page":"395","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8859999775886536},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pediatric-liver-failure","display_name":"pediatric liver failure","score":0.48100000619888306},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9940000176429749},{"id":"https://openalex.org/keywords/idiosyncratic-adverse-drug-reactions","display_name":"idiosyncratic drug reactions","score":0.9020000100135803},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.6169999837875366},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.8140000104904175},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.953093409538269},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.74393630027771},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.7324436902999878},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7252837419509888},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.7028370499610901},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.64494389295578},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5278344750404358},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.5067494511604309},{"id":"https://openalex.org/C2994427840","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Liver failure","level":2,"score":0.4710041582584381},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.419749915599823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40117406845092773},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3224065899848938},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2642294764518738}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mpg.0b013e3181709464","doi":"https://doi.org/10.1097/mpg.0b013e3181709464","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0b013e3181709464","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},{"id":"pmid:18852631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18852631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric gastroenterology and nutrition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W17312625","https://openalex.org/W26625382","https://openalex.org/W39427089","https://openalex.org/W48494795","https://openalex.org/W94846157","https://openalex.org/W127852560","https://openalex.org/W179126939","https://openalex.org/W198222425","https://openalex.org/W1420971326","https://openalex.org/W1485961568","https://openalex.org/W1496869977","https://openalex.org/W1516424626","https://openalex.org/W1566826692","https://openalex.org/W1593737715","https://openalex.org/W1744955600","https://openalex.org/W1789715727","https://openalex.org/W1964117957","https://openalex.org/W1966268750","https://openalex.org/W1966913850","https://openalex.org/W1972568864","https://openalex.org/W1974368480","https://openalex.org/W1976182925","https://openalex.org/W1980734565","https://openalex.org/W1981062378","https://openalex.org/W1981761668","https://openalex.org/W1984200234","https://openalex.org/W1985310665","https://openalex.org/W1987968174","https://openalex.org/W1988396798","https://openalex.org/W1989219811","https://openalex.org/W1989694996","https://openalex.org/W1989908494","https://openalex.org/W1993860201","https://openalex.org/W1994400976","https://openalex.org/W1995161323","https://openalex.org/W1996604226","https://openalex.org/W2000760635","https://openalex.org/W2003006864","https://openalex.org/W2005831280","https://openalex.org/W2006221942","https://openalex.org/W2007946569","https://openalex.org/W2010958495","https://openalex.org/W2017821181","https://openalex.org/W2019220886","https://openalex.org/W2020156348","https://openalex.org/W2024705942","https://openalex.org/W2029162899","https://openalex.org/W2029867887","https://openalex.org/W2034979604","https://openalex.org/W2036599528","https://openalex.org/W2037120680","https://openalex.org/W2037537545","https://openalex.org/W2038697517","https://openalex.org/W2039265908","https://openalex.org/W2041231288","https://openalex.org/W2043674347","https://openalex.org/W2044109024","https://openalex.org/W2046744217","https://openalex.org/W2047702379","https://openalex.org/W2048518475","https://openalex.org/W2048900211","https://openalex.org/W2050468237","https://openalex.org/W2051520766","https://openalex.org/W2052788628","https://openalex.org/W2055765891","https://openalex.org/W2056450026","https://openalex.org/W2057716737","https://openalex.org/W2058955933","https://openalex.org/W2059261576","https://openalex.org/W2061640296","https://openalex.org/W2064727915","https://openalex.org/W2067978628","https://openalex.org/W2073520433","https://openalex.org/W2074693161","https://openalex.org/W2076053525","https://openalex.org/W2078678407","https://openalex.org/W2080139528","https://openalex.org/W2080222650","https://openalex.org/W2082251370","https://openalex.org/W2082483213","https://openalex.org/W2085106324","https://openalex.org/W2093900455","https://openalex.org/W2096531411","https://openalex.org/W2099815282","https://openalex.org/W2100015029","https://openalex.org/W2104947000","https://openalex.org/W2105685356","https://openalex.org/W2109115714","https://openalex.org/W2123876596","https://openalex.org/W2127244694","https://openalex.org/W2133336498","https://openalex.org/W2134724442","https://openalex.org/W2135416796","https://openalex.org/W2144628414","https://openalex.org/W2146544936","https://openalex.org/W2147533305","https://openalex.org/W2157712198","https://openalex.org/W2166385647","https://openalex.org/W2166822423","https://openalex.org/W2168467913","https://openalex.org/W2241443511","https://openalex.org/W2401723191","https://openalex.org/W2407650805","https://openalex.org/W2409891526","https://openalex.org/W2410121739","https://openalex.org/W2410956611","https://openalex.org/W2428546646","https://openalex.org/W4240417092","https://openalex.org/W4244518771","https://openalex.org/W4247758177"],"related_works":["https://openalex.org/W3119509730","https://openalex.org/W3088662699","https://openalex.org/W1506818533","https://openalex.org/W2991014362","https://openalex.org/W2979834610","https://openalex.org/W2037407520","https://openalex.org/W2041231288","https://openalex.org/W2588753771","https://openalex.org/W763333542","https://openalex.org/W2346318620"],"abstract_inverted_index":{"Drug-induced":[0],"acute":[1],"liver":[2,88],"failure":[3],"(ALF)":[4],"accounts":[5],"for":[6,44,83,96,100],"approximately":[7],"20%":[8],"of":[9,17,52,60,87,104,111,125,140,151,179,183,191],"ALF":[10,18,54,62,195],"in":[11,19,55,63,65,159,196],"children":[12,56,64],"and":[13,69,79,93,114,122,128,147,194],"a":[14],"higher":[15],"percentage":[16],"adults.":[20],"Although":[21,149],"most":[22,49,97,150],"patients":[23],"experience":[24,158],"milder":[25],"drug":[26],"hepatotoxic":[27],"reactions":[28,95],"such":[29,76],"as":[30,77],"hepatitis,":[31],"cholestasis,":[32],"or":[33,136,171],"asymptomatic":[34],"enzyme":[35],"elevation,":[36],"it":[37],"is":[38,57,106,155,167],"important":[39],"to":[40,46,133,169],"recognize":[41],"the":[42,66,70,102,109,120,141,152,180,189],"potential":[43,181],"progression":[45],"ALF.":[47],"The":[48,85],"common":[50],"cause":[51],"drug-induced":[53,126],"acetaminophen":[58],"(15%":[59],"all":[61],"United":[67,71],"Kingdom":[68],"States),":[72],"whereas":[73],"other":[74],"drugs":[75],"antituberculous":[78],"antiepileptic":[80],"therapy":[81],"account":[82],"5%.":[84],"pathogenesis":[86],"injury":[89,105],"includes":[90],"direct":[91],"hepatotoxicity":[92,127,182,193],"idiosyncratic":[94],"drugs,":[98],"although":[99],"others":[101],"mechanism":[103,139],"assumed":[107],"on":[108,157],"basis":[110],"clinical":[112,143],"presentation":[113],"hepatic":[115],"histological":[116],"findings.":[117],"We":[118],"review":[119],"adult":[121,160],"pediatric":[123,175,197],"literature":[124],"ALF,":[129],"with":[130],"special":[131],"attention":[132],"commonly":[134,184],"used":[135],"offending":[137],"medications,":[138],"toxicity,":[142],"presentation,":[144],"diagnosis,":[145],"treatment,":[146],"prognosis.":[148],"available":[153],"information":[154],"based":[156],"patients,":[161],"we":[162,172],"have":[163,173],"included":[164],"that":[165],"which":[166],"applicable":[168],"children,":[170],"cited":[174],"examples.":[176],"Enhanced":[177],"awareness":[178],"prescribed":[185],"medications":[186],"may":[187],"minimize":[188],"frequency":[190],"serious":[192],"patients.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}