{"id":"https://openalex.org/W1977548751","doi":"https://doi.org/10.1089/omi.2011.0102","title":"A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?","display_name":"A Structural Analysis of Glycosaminoglycans from Lethal and Nonlethal Breast Cancer Tissues: Toward a Novel Class of Theragnostics for Personalized Medicine in Oncology?","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W1977548751","doi":"https://doi.org/10.1089/omi.2011.0102","mag":"1977548751","pmid":"https://pubmed.ncbi.nlm.nih.gov/22401653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3300064"},"language":"en","primary_location":{"id":"doi:10.1089/omi.2011.0102","doi":"https://doi.org/10.1089/omi.2011.0102","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2011.0102","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3300064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000528069","display_name":"Amanda M. Weyers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Weyers","raw_affiliation_strings":["Rensselaer Polytechnic Institute","Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103056115","display_name":"Bo Yang","orcid":"https://orcid.org/0000-0001-7356-0904","observed_orcids":["https://orcid.org/0000-0001-7356-0904","https://orcid.org/0009-0008-3935-8700"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Yang","raw_affiliation_strings":["Rensselaer Polytechnic Institute","Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074254878","display_name":"Dae Sung Yoon","orcid":"https://orcid.org/0000-0002-6447-2862","observed_orcids":["https://orcid.org/0000-0002-6447-2862","https://orcid.org/0000-0002-7549-3829"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]},{"id":"https://openalex.org/I4210105394","display_name":"Konyang University Hospital","ror":"https://ror.org/01eksj726","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210105394"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae Sung Yoon","raw_affiliation_strings":["Konyang University","Department of Surgery, College of Medicine, Konyang University, Konyang Hospital, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Konyang University","institution_ids":["https://openalex.org/I165028127"]},{"raw_affiliation_string":"Department of Surgery, College of Medicine, Konyang University, Konyang Hospital, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127","https://openalex.org/I4210105394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101872444","display_name":"Jong\u2010Hwan Park","orcid":"https://orcid.org/0000-0003-4664-5640","observed_orcids":["https://orcid.org/0000-0003-4664-5640"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Hwan Park","raw_affiliation_strings":["Konyang University","Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Konyang University","institution_ids":["https://openalex.org/I165028127"]},{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069724772","display_name":"Fuming Zhang","orcid":"https://orcid.org/0000-0003-2803-3704","observed_orcids":["https://orcid.org/0000-0003-2803-3704"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuming Zhang","raw_affiliation_strings":["Rensselaer Polytechnic Institute","Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106083359","display_name":"Kyung\u2010Bok Lee","orcid":"https://orcid.org/0000-0003-1495-3462","observed_orcids":["https://orcid.org/0000-0003-1495-3462","https://orcid.org/0000-0003-2663-7483"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung Bok Lee","raw_affiliation_strings":["Konyang University","Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Konyang University","institution_ids":["https://openalex.org/I165028127"]},{"raw_affiliation_string":"Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056210370","display_name":"Robert J. Linhardt","orcid":"https://orcid.org/0000-0003-2219-5833","observed_orcids":["https://orcid.org/0000-0003-2219-5833"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert J. Linhardt","raw_affiliation_strings":["Rensselaer Polytechnic Institute","Department of Biology and Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Biology and Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056210370","https://openalex.org/A5106083359"],"corresponding_institution_ids":["https://openalex.org/I165028127","https://openalex.org/I165799507"],"apc_list":null,"apc_paid":null,"fwci":2.8755,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.89812516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"79","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.8769999742507935},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sulfation-patterns","display_name":"sulfation patterns","score":0.7960000038146973},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/disaccharide-composition","display_name":"disaccharide composition","score":0.7940000295639038},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.6669999957084656},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.851304829120636},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.8289731740951538},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6573055982589722},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5955667495727539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45992952585220337},{"id":"https://openalex.org/C2777346074","wikidata":"https://www.wikidata.org/wiki/Q173600","display_name":"Disaccharide","level":2,"score":0.45744866132736206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3831137716770172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38251757621765137},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38084396719932556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3173717260360718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2872507572174072}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/omi.2011.0102","doi":"https://doi.org/10.1089/omi.2011.0102","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2011.0102","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2582410","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3300064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3300064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3300064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS","raw_type":"Text"},{"id":"pmid:22401653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22401653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Omics : a journal of integrative biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2582410","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3300064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1876351644","display_name":null,"funder_award_id":"GM38060","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3790505976","display_name":"Sequencing the Polysaccharide Component of Proteoglycans","funder_award_id":"R01GM038060","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G49555899","display_name":"Biomolecular Science and Engineering Training Program","funder_award_id":"T32GM067545","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W176315691","https://openalex.org/W1491748226","https://openalex.org/W1647207353","https://openalex.org/W1717531886","https://openalex.org/W1726775692","https://openalex.org/W1896781151","https://openalex.org/W1915381763","https://openalex.org/W1963976200","https://openalex.org/W1966604593","https://openalex.org/W1967227961","https://openalex.org/W1976740882","https://openalex.org/W1980479109","https://openalex.org/W1981896323","https://openalex.org/W1986057432","https://openalex.org/W1987088555","https://openalex.org/W1992319286","https://openalex.org/W1992425067","https://openalex.org/W1996795546","https://openalex.org/W1997735550","https://openalex.org/W1999048631","https://openalex.org/W1999652145","https://openalex.org/W2008581828","https://openalex.org/W2012056018","https://openalex.org/W2014950114","https://openalex.org/W2021089210","https://openalex.org/W2022295066","https://openalex.org/W2027220201","https://openalex.org/W2036098109","https://openalex.org/W2041096316","https://openalex.org/W2047533646","https://openalex.org/W2048573811","https://openalex.org/W2050744599","https://openalex.org/W2051896841","https://openalex.org/W2054920879","https://openalex.org/W2056680779","https://openalex.org/W2062606014","https://openalex.org/W2068017580","https://openalex.org/W2071754810","https://openalex.org/W2072446135","https://openalex.org/W2077007440","https://openalex.org/W2077607839","https://openalex.org/W2081660608","https://openalex.org/W2087774979","https://openalex.org/W2097977053","https://openalex.org/W2098317823","https://openalex.org/W2104205949","https://openalex.org/W2111266810","https://openalex.org/W2112708564","https://openalex.org/W2132600369","https://openalex.org/W2134709252","https://openalex.org/W2141193237","https://openalex.org/W2155815655","https://openalex.org/W2156014566","https://openalex.org/W2163330134","https://openalex.org/W2164071805","https://openalex.org/W2409453570","https://openalex.org/W2942682970","https://openalex.org/W4234140157","https://openalex.org/W4234403015"],"related_works":["https://openalex.org/W7099816654","https://openalex.org/W2414668811","https://openalex.org/W1988702778","https://openalex.org/W1979009164","https://openalex.org/W1771887010","https://openalex.org/W3135631294","https://openalex.org/W2210048592","https://openalex.org/W2032514625","https://openalex.org/W2148660029","https://openalex.org/W178972544"],"abstract_inverted_index":{"Cancer":[0],"is":[1],"one":[2],"of":[3,50,77,99,105,148,157,175,180,240,261],"the":[4,46,145,155,158,181,237,259],"leading":[5],"noncommunicable":[6],"diseases":[7],"that":[8,19,76,84,196,218,230,257],"vastly":[9],"impacts":[10],"both":[11],"developed":[12],"and":[13,36,48,55,117,133,151,177,204,207,216],"developing":[14],"countries.":[15],"Truly":[16],"innovative":[17],"diagnostics":[18],"inform":[20],"disease":[21],"susceptibility,":[22],"prognosis,":[23],"and/or":[24],"response":[25],"to":[26],"treatment":[27],"(theragnostics)":[28],"are":[29,233],"seriously":[30],"needed":[31],"for":[32,39],"global":[33],"public":[34],"health":[35],"personalized":[37],"medicine":[38],"patients":[40,130,211,265],"with":[41,131,163,172,212],"cancer.":[42,135,269],"This":[43],"study":[44],"examined":[45],"structure":[47],"content":[49,65],"glycosaminoglycans":[51,85],"(GAGs)":[52],"in":[53,112,125,142,154,169,199,236,254,263],"lethal":[54,70,132,164],"nonlethal":[56,134],"breast":[57],"cancer":[58,71,165,215,217],"tissues":[59,206,209],"from":[60,67,86,129,189,210],"six":[61],"patients.":[62],"The":[63],"glycosaminoglycan":[64],"isolated":[66,128],"tissue":[68,88,138,243],"containing":[69],"tumors":[72,262],"was":[73,219],"approximately":[74,106],"twice":[75],"other":[78],"tissues.":[79],"Molecular":[80],"weight":[81,92],"analysis":[82,109],"showed":[83,139,166],"cancerous":[87,116,137,203],"had":[89],"a":[90,167,190],"longer":[91],"average":[93,98],"chain":[94],"length":[95],"by":[96,222],"an":[97,103,140,152],"five":[100],"disaccharide":[101,160],"units,":[102],"increase":[104,141,153],"15%.":[107],"Dissacharide":[108],"found":[110],"differences":[111,124],"sulfation":[113,123,143],"patterns":[114],"between":[115,202,208],"normal":[118],"tissues,":[119],"as":[120,122,242],"well":[121],"GAG":[126,255],"chains":[127,150],"Specifically,":[136],"at":[144],"\"6S\"":[146,176],"position":[147],"CS":[149],"levels":[156,174,179],"HS":[159,170],"NSCS.":[161],"Patients":[162],"decrease":[168],"sulfation,":[171],"lower":[173],"higher":[178],"unsulfated":[182],"\"0S\"":[183],"disaccharide.":[184],"Although":[185],"these":[186,226],"findings":[187],"come":[188],"limited":[191],"sample":[192],"size,":[193],"they":[194,267],"indicate":[195],"structural":[197,251],"changes":[198,235],"GAGs":[200,241],"exist":[201],"noncancerous":[205],"highly":[213],"metastatic":[214],"successfully":[220],"treated":[221],"chemotherapy.":[223],"Based":[224],"on":[225],"findings,":[227],"we":[228],"hypothesize":[229],"(1)":[231],"there":[232,247],"putative":[234],"body's":[238],"construction":[239],"becomes":[244],"cancerous;":[245],"(2)":[246],"may":[248],"be":[249],"innate":[250],"person-to-person":[252],"variations":[253],"composition":[256],"facilitate":[258],"metastasis":[260],"some":[264],"when":[266],"develop":[268]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}