{"id":"https://openalex.org/W1977546488","doi":"https://doi.org/10.1016/0028-3908(81)90105-2","title":"Binding of (3H)-5,5 diphenylhydantoin to rat brain membranes","display_name":"Binding of (3H)-5,5 diphenylhydantoin to rat brain membranes","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W1977546488","doi":"https://doi.org/10.1016/0028-3908(81)90105-2","mag":"1977546488","pmid":"https://pubmed.ncbi.nlm.nih.gov/6275289"},"language":"en","primary_location":{"id":"doi:10.1016/0028-3908(81)90105-2","doi":"https://doi.org/10.1016/0028-3908(81)90105-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0028-3908(81)90105-2","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D.S. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.S. Shah","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078753587","display_name":"Pierre Chambon","orcid":"https://orcid.org/0000-0001-7394-3729","observed_orcids":["https://orcid.org/0000-0001-7394-3729"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Chambon","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Guidotti","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032 U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":0.9146,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.65629494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"11","first_page":"1115","last_page":"1119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-5-diphenylhydantoin","display_name":"5,5-diphenylhydantoin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.6389999985694885},{"id":"https://openalex.org/keywords/high-affinity-binding-sites","display_name":"high-affinity binding sites","score":0.6489999890327454},{"id":"https://openalex.org/keywords/low-affinity-binding-sites","display_name":"low-affinity binding sites","score":0.7490000128746033},{"id":"https://openalex.org/keywords/brain-membranes","display_name":"brain membranes","score":0.5149999856948853},{"id":"https://openalex.org/keywords/binding-inhibition","display_name":"binding inhibition","score":0.5139999985694885},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.781000018119812},{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":0.9900000095367432},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pronase","display_name":"pronase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.9160000085830688},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.6850000023841858},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.670992374420166},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.6116044521331787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5863505601882935},{"id":"https://openalex.org/C2776708817","wikidata":"https://www.wikidata.org/wiki/Q4380751","display_name":"Pronase","level":4,"score":0.565520167350769},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5168245434761047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4586884677410126},{"id":"https://openalex.org/C85196483","wikidata":"https://www.wikidata.org/wiki/Q6545857","display_name":"Ligand binding assay","level":3,"score":0.41439077258110046},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.36757972836494446},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20726534724235535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18469282984733582},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.15573549270629883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09091421961784363},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0028-3908(81)90105-2","doi":"https://doi.org/10.1016/0028-3908(81)90105-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0028-3908(81)90105-2","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:6275289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6275289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W100576144","https://openalex.org/W1684853394","https://openalex.org/W1775749144","https://openalex.org/W1896155046","https://openalex.org/W1990880840","https://openalex.org/W2051483039","https://openalex.org/W2066628109","https://openalex.org/W2112545619"],"related_works":["https://openalex.org/W2017979887","https://openalex.org/W3105494344","https://openalex.org/W1965840851","https://openalex.org/W2084536694","https://openalex.org/W2158907779","https://openalex.org/W1994485637","https://openalex.org/W2112545619","https://openalex.org/W2403210035","https://openalex.org/W2625629606","https://openalex.org/W2046874546"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
