{"id":"https://openalex.org/W1977529564","doi":"https://doi.org/10.1016/j.febslet.2011.04.037","title":"Mediators of oligodendrocyte differentiation during remyelination","display_name":"Mediators of oligodendrocyte differentiation during remyelination","publication_year":2011,"publication_date":"2011-04-29","ids":{"openalex":"https://openalex.org/W1977529564","doi":"https://doi.org/10.1016/j.febslet.2011.04.037","mag":"1977529564","pmid":"https://pubmed.ncbi.nlm.nih.gov/21539842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3158966"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2011.04.037","doi":"https://doi.org/10.1016/j.febslet.2011.04.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.04.037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.04.037","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.04.037","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031732446","display_name":"Jigisha R. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jigisha R. Patel","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046722897","display_name":"Robyn S. Klein","orcid":"https://orcid.org/0000-0003-0281-1352","observed_orcids":["https://orcid.org/0000-0003-0281-1352"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robyn S. Klein","raw_affiliation_strings":["Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046722897"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.4239,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.33,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"585","issue":"23","first_page":"3730","last_page":"3737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.996999979019165},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.4729999899864197},{"id":"https://openalex.org/keywords/axonal-pathology","display_name":"axonal pathology","score":0.6050000190734863},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.9597655534744263},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.798554003238678},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7845571041107178},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7558589577674866},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7318698763847351},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5945489406585693},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5940672159194946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47023457288742065},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.4437953233718872},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.42775222659111023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32652556896209717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2781166434288025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.febslet.2011.04.037","doi":"https://doi.org/10.1016/j.febslet.2011.04.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.04.037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.04.037","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:21539842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21539842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2512426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3158966","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3158966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3158966","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2011.04.037","doi":"https://doi.org/10.1016/j.febslet.2011.04.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.04.037","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.04.037","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5080950515","display_name":null,"funder_award_id":"NS059560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5130636508","display_name":"Biomarkers and Pathogenesis of MS: From Mouse to Human","funder_award_id":"P01NS059560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5441180306","display_name":"Neuroprotection and repair during West Nile Virus Encephalitis","funder_award_id":"R01NS052632","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977529564.pdf","grobid_xml":"https://content.openalex.org/works/W1977529564.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W45109146","https://openalex.org/W109974507","https://openalex.org/W201711305","https://openalex.org/W222520529","https://openalex.org/W1509596990","https://openalex.org/W1536622417","https://openalex.org/W1584712535","https://openalex.org/W1678027485","https://openalex.org/W1760682360","https://openalex.org/W1791569952","https://openalex.org/W1843199965","https://openalex.org/W1933220919","https://openalex.org/W1960757861","https://openalex.org/W1966248821","https://openalex.org/W1966302674","https://openalex.org/W1966983102","https://openalex.org/W1968376159","https://openalex.org/W1972725262","https://openalex.org/W1976007204","https://openalex.org/W1977103562","https://openalex.org/W1978825269","https://openalex.org/W1980132687","https://openalex.org/W1986415814","https://openalex.org/W1988178045","https://openalex.org/W1988358907","https://openalex.org/W1988589306","https://openalex.org/W1992272763","https://openalex.org/W1993824683","https://openalex.org/W1998444616","https://openalex.org/W2000665475","https://openalex.org/W2001810970","https://openalex.org/W2005797914","https://openalex.org/W2006593236","https://openalex.org/W2013807114","https://openalex.org/W2014490965","https://openalex.org/W2015858554","https://openalex.org/W2017346008","https://openalex.org/W2017395674","https://openalex.org/W2021786345","https://openalex.org/W2021898378","https://openalex.org/W2021941118","https://openalex.org/W2022380830","https://openalex.org/W2026171674","https://openalex.org/W2027430951","https://openalex.org/W2030104330","https://openalex.org/W2035098555","https://openalex.org/W2038651295","https://openalex.org/W2038757125","https://openalex.org/W2038964409","https://openalex.org/W2040207158","https://openalex.org/W2041264117","https://openalex.org/W2042810495","https://openalex.org/W2043258449","https://openalex.org/W2046716216","https://openalex.org/W2050732746","https://openalex.org/W2050989030","https://openalex.org/W2057361877","https://openalex.org/W2058718560","https://openalex.org/W2060811783","https://openalex.org/W2061631515","https://openalex.org/W2062133707","https://openalex.org/W2063381162","https://openalex.org/W2063639010","https://openalex.org/W2063653640","https://openalex.org/W2064286176","https://openalex.org/W2064769936","https://openalex.org/W2066356973","https://openalex.org/W2077702475","https://openalex.org/W2079544700","https://openalex.org/W2083218881","https://openalex.org/W2083898995","https://openalex.org/W2084866609","https://openalex.org/W2085879860","https://openalex.org/W2088969512","https://openalex.org/W2089295489","https://openalex.org/W2094676206","https://openalex.org/W2094719314","https://openalex.org/W2097546542","https://openalex.org/W2098499905","https://openalex.org/W2099365888","https://openalex.org/W2100904149","https://openalex.org/W2108005154","https://openalex.org/W2109577352","https://openalex.org/W2109734495","https://openalex.org/W2113672425","https://openalex.org/W2114727688","https://openalex.org/W2122665472","https://openalex.org/W2122971055","https://openalex.org/W2123661628","https://openalex.org/W2125650861","https://openalex.org/W2127980641","https://openalex.org/W2128464557","https://openalex.org/W2129381666","https://openalex.org/W2130117660","https://openalex.org/W2132759102","https://openalex.org/W2139485237","https://openalex.org/W2140413558","https://openalex.org/W2141275983","https://openalex.org/W2141837555","https://openalex.org/W2143076600","https://openalex.org/W2143890525","https://openalex.org/W2149942972","https://openalex.org/W2155510294","https://openalex.org/W2158064024","https://openalex.org/W2160412284","https://openalex.org/W2161766823","https://openalex.org/W2169924875","https://openalex.org/W2241770530","https://openalex.org/W2297276306","https://openalex.org/W2312313151","https://openalex.org/W2480036115"],"related_works":["https://openalex.org/W4412893147","https://openalex.org/W2365845908","https://openalex.org/W2112285382","https://openalex.org/W1494387198","https://openalex.org/W2176522607","https://openalex.org/W2048082433","https://openalex.org/W1558134194","https://openalex.org/W1901736351","https://openalex.org/W2928739568","https://openalex.org/W2104111051"],"abstract_inverted_index":{"Myelin,":[0],"a":[1],"dielectric":[2],"sheath":[3],"that":[4,73,106],"wraps":[5],"large":[6],"axons":[7],"in":[8,91],"the":[9,32,70,100,108,117],"central":[10,33],"and":[11,87,103],"peripheral":[12],"nervous":[13,34],"systems,":[14],"is":[15],"essential":[16,78],"for":[17,79],"proper":[18],"conductance":[19],"of":[20,47,99,111],"axon":[21],"potentials.":[22],"In":[23],"multiple":[24],"sclerosis":[25],"(MS),":[26],"autoimmune-mediated":[27],"damage":[28],"to":[29,38,43,57,64,83],"myelin":[30,66,85],"within":[31,116],"system":[35],"(CNS)":[36],"leads":[37],"progressive":[39],"disability":[40,90],"primarily":[41],"due":[42],"limited":[44],"endogenous":[45],"repair":[46,86],"demyelination":[48],"with":[49],"associated":[50],"axonal":[51],"pathology.":[52],"While":[53],"treatments":[54,61],"are":[55,62,76],"available":[56,63],"limit":[58,89],"demyelination,":[59],"no":[60],"promote":[65,74,84],"repair.":[67],"Studies":[68],"examining":[69],"molecular":[71],"mechanisms":[72],"remyelination":[75],"therefore":[77],"identifying":[80],"therapeutic":[81],"targets":[82],"thereby":[88],"MS.":[92],"Here,":[93],"we":[94],"present":[95],"our":[96],"current":[97],"understanding":[98],"critical":[101],"extracellular":[102],"intracellular":[104],"pathways":[105],"regulate":[107],"remyelinating":[109],"capabilities":[110],"oligodendrocyte":[112],"precursor":[113],"cells":[114],"(OPCs)":[115],"adult":[118],"CNS.":[119]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
