{"id":"https://openalex.org/W1977445279","doi":"https://doi.org/10.1089/hum.2007.181","title":"Viral Interleukin-10 Gene Transfer Prevents Liver Ischemia\u2013Reperfusion Injury: Toll-Like Receptor-4 and Heme Oxygenase-1 Signaling in Innate and Adaptive Immunity","display_name":"Viral Interleukin-10 Gene Transfer Prevents Liver Ischemia\u2013Reperfusion Injury: Toll-Like Receptor-4 and Heme Oxygenase-1 Signaling in Innate and Adaptive Immunity","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W1977445279","doi":"https://doi.org/10.1089/hum.2007.181","mag":"1977445279","pmid":"https://pubmed.ncbi.nlm.nih.gov/17439357"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2007.181","doi":"https://doi.org/10.1089/hum.2007.181","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2007.181","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045209569","display_name":"Bibo Ke","orcid":"https://orcid.org/0000-0002-1885-1538","observed_orcids":["https://orcid.org/0000-0002-1885-1538"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibo Ke","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554008","display_name":"Xiu\u2010Da Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiu-Da Shen","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111507898","display_name":"Sei-ichiro Tsuchihashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sei-Ichiro Tsuchihashi","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023740323","display_name":"Jes\u00fas A. Araujo","orcid":"https://orcid.org/0000-0001-8279-8922","observed_orcids":["https://orcid.org/0000-0001-8279-8922"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus A. Araujo","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075909338","display_name":"Ronald W. Busuttil","orcid":"https://orcid.org/0000-0001-8157-1531","observed_orcids":["https://orcid.org/0000-0001-8157-1531"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald W. Busuttil","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075053869","display_name":"Thomas Ritter","orcid":"https://orcid.org/0000-0001-7709-8489","observed_orcids":["https://orcid.org/0000-0001-7709-8489"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Ritter","raw_affiliation_strings":["Institute of Medical Immunology, Humboldt University, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Immunology, Humboldt University, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016218484","display_name":"Jerzy W. Kupiec\u2010Weglinski","orcid":"https://orcid.org/0000-0001-8976-4872","observed_orcids":["https://orcid.org/0000-0001-8976-4872"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerzy W. Kupiec-Weglinski","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9816,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94781865,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"4","first_page":"355","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.890999972820282},{"id":"https://openalex.org/keywords/viral-vector-gene-delivery","display_name":"viral gene delivery","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7940000295639038},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7450000047683716},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6970000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5139999985694885},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5870000123977661},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neutrophil-accumulation","display_name":"neutrophil accumulation","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.6551311016082764},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6268155574798584},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5372775197029114},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5107269287109375},{"id":"https://openalex.org/C2778904781","wikidata":"https://www.wikidata.org/wiki/Q513486","display_name":"Kupffer cell","level":2,"score":0.4958978593349457},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4723542630672455},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.46145591139793396},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4481462836265564},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.4456756114959717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43961814045906067},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4256740212440491},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4145219922065735},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40140408277511597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3882952034473419},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.3643995523452759},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3640243411064148},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3084212839603424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29152679443359375},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.22571498155593872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08800894021987915},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.2007.181","doi":"https://doi.org/10.1089/hum.2007.181","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2007.181","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:17439357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17439357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2091283467","display_name":"CD4+ T REG CELLS IN MAINTENANCE OF TRANSPLANT TOLERANCE","funder_award_id":"R01AI042223","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6075649901","display_name":null,"funder_award_id":"AI23847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G869156900","display_name":null,"funder_award_id":"AI42223","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898292","display_name":"HuR/HIF \u2013 SIRT1 Signaling Axis in Liver Transplant Rejuvenation","funder_award_id":"R01DK062357","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W162447880","https://openalex.org/W1483162601","https://openalex.org/W1489742081","https://openalex.org/W1515615230","https://openalex.org/W1517658874","https://openalex.org/W1561573262","https://openalex.org/W1639400191","https://openalex.org/W1969921405","https://openalex.org/W1970598946","https://openalex.org/W1981540584","https://openalex.org/W2006199966","https://openalex.org/W2006687037","https://openalex.org/W2009183800","https://openalex.org/W2009599333","https://openalex.org/W2018229946","https://openalex.org/W2020941408","https://openalex.org/W2022276433","https://openalex.org/W2027679783","https://openalex.org/W2033818911","https://openalex.org/W2034042813","https://openalex.org/W2036518600","https://openalex.org/W2036824735","https://openalex.org/W2046182982","https://openalex.org/W2047999732","https://openalex.org/W2049515086","https://openalex.org/W2050971607","https://openalex.org/W2055336483","https://openalex.org/W2059829735","https://openalex.org/W2060546545","https://openalex.org/W2065284764","https://openalex.org/W2068326328","https://openalex.org/W2069008759","https://openalex.org/W2072353087","https://openalex.org/W2083466222","https://openalex.org/W2093778666","https://openalex.org/W2099883737","https://openalex.org/W2101363646","https://openalex.org/W2101771134","https://openalex.org/W2106877484","https://openalex.org/W2110190262","https://openalex.org/W2113552021","https://openalex.org/W2116878408","https://openalex.org/W2121841947","https://openalex.org/W2132415356","https://openalex.org/W2133556861","https://openalex.org/W2135921495","https://openalex.org/W2145530136","https://openalex.org/W2153552716","https://openalex.org/W2161074777","https://openalex.org/W2182889493","https://openalex.org/W2191654227","https://openalex.org/W2313191788","https://openalex.org/W4244684773","https://openalex.org/W4301882029"],"related_works":["https://openalex.org/W2068326328","https://openalex.org/W2036824735","https://openalex.org/W1975658673","https://openalex.org/W2090237784","https://openalex.org/W2058167502","https://openalex.org/W2089573702","https://openalex.org/W1583893196","https://openalex.org/W2022358295","https://openalex.org/W2353825297","https://openalex.org/W2127813125"],"abstract_inverted_index":{"Ischemia-reperfusion":[0],"injury":[1],"(IRI)":[2],"contributes":[3],"to":[4,190],"early":[5],"and":[6,62,68,84,110,139,146,168,177,196,208,215,238,248],"late":[7],"dysfunction":[8],"of":[9,27,41,82,93,99,106,130,235,245],"liver":[10,72,162],"transplants.":[11],"We":[12,35],"have":[13,36,118],"shown":[14,119],"that":[15,39],"sentinel":[16],"Toll-like":[17],"receptor-4":[18],"(TLR4)":[19],"plays":[20],"a":[21,75],"key":[22],"role":[23],"in":[24,65,193,230],"the":[25],"activation":[26],"T":[28],"cell":[29],"immune":[30],"responses":[31],"during":[32,71],"hepatic":[33,121,228,259],"IRI.":[34,73,163,191,264],"also":[37],"documented":[38],"overexpression":[40],"heme":[42],"oxygenase-1":[43],"(HO-1)":[44],"exerts":[45,253],"potent":[46],"cytoprotective":[47,255],"effects.":[48],"This":[49],"study":[50],"analyzes":[51],"how":[52],"adenovirus":[53],"(Ad)-based":[54],"viral":[55],"interleukin-10":[56],"(vIL-10)":[57],"gene":[58,225],"transfer":[59,226],"affects":[60],"TLR4":[61,207],"HO-1":[63,111,169,178,197,214,247],"signaling":[64],"host":[66],"innate":[67,236],"adaptive":[69,239],"immunity":[70],"Using":[74],"partial":[76],"lobar":[77],"warm":[78,100],"IRI":[79,131,229],"model,":[80],"groups":[81],"wild-type":[83,109,167,176,195],"HO-1(+/-)":[85],"knockout":[86],"(KO)":[87],"mice":[88,114,181,200],"were":[89,153],"assessed":[90],"for":[91],"severity":[92],"hepatocellular":[94,187],"damage":[95,188],"after":[96],"90":[97],"min":[98],"ischemia":[101],"followed":[102],"by":[103,251,263],"6":[104],"hr":[105],"reperfusion.":[107],"Both":[108],"(+/-)":[112,170,179,198],"KO":[113,171,180,199],"treated":[115,182,201],"with":[116,158,183,202,212,220,232],"Ad-vIL-10":[117,203],"improved":[120],"function":[122,256],"(serum":[123],"glutamic-oxaloacetic":[124],"transaminase":[125],"levels),":[126],"ameliorated":[127],"histological":[128],"signs":[129],"(Suzuki's":[132],"score),":[133],"decreased":[134],"neutrophil":[135],"accumulation":[136],"(myeloperoxidase":[137],"activity),":[138],"depressed":[140,206,233],"tumor":[141],"necrosis":[142],"factor-alpha/IL-1beta,":[143],"IL-2/interferon-gamma,":[144],"E-selectin,":[145],"macrophage":[147],"inflammatory":[148,260],"protein-2":[149],"expression.":[150],"These":[151],"effects":[152],"IL-10":[154],"dependent":[155],"as":[156,173,175,218],"treatment":[157],"neutralizing":[159],"antibody":[160],"re-created":[161],"In":[164],"contrast,":[165],"untreated":[166],"mice,":[172],"well":[174],"Ad-beta-Gal,":[184],"showed":[185],"severe":[186],"due":[189],"Unlike":[192],"controls,":[194],"revealed":[204],"markedly":[205],"NF-kappaB":[209],"expression,":[210,217],"along":[211],"increased":[213],"Bcl-2/Bcl-x(L)":[216,250],"compared":[219],"respective":[221],"controls.":[222],"Thus,":[223],"vIL-10":[224,252],"prevents":[227],"association":[231],"expression":[234],"TLR4,":[237],"Th1":[240],"cytokine/chemokine":[241],"programs.":[242],"The":[243],"induction":[244],"antioxidant":[246],"anti-apoptotic":[249],"synergistic":[254],"against":[257],"antigen-independent":[258],"response":[261],"triggered":[262]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}