{"id":"https://openalex.org/W1977437553","doi":"https://doi.org/10.1002/jbm.a.34112","title":"Design of injectable organic\u2013inorganic hybrid for bone tissue repair","display_name":"Design of injectable organic\u2013inorganic hybrid for bone tissue repair","publication_year":2012,"publication_date":"2012-05-12","ids":{"openalex":"https://openalex.org/W1977437553","doi":"https://doi.org/10.1002/jbm.a.34112","mag":"1977437553","pmid":"https://pubmed.ncbi.nlm.nih.gov/22581691"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.34112","doi":"https://doi.org/10.1002/jbm.a.34112","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.34112","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039955895","display_name":"M. Dess\u00ec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariagemiliana Dess\u00ec","raw_affiliation_strings":["Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024553570","display_name":"Maria Grazia Raucci","orcid":"https://orcid.org/0000-0002-0516-4181","observed_orcids":["https://orcid.org/0000-0002-0516-4181"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Grazia Raucci","raw_affiliation_strings":["Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073352003","display_name":"Stefania Zeppetelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Zeppetelli","raw_affiliation_strings":["Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102712193","display_name":"Luigi Ambrosio","orcid":"https://orcid.org/0000-0002-8367-2405","observed_orcids":["https://orcid.org/0000-0002-8367-2405"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Ambrosio","raw_affiliation_strings":["Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Composite and Biomedical Materials, National Research Council of Italy, Piazzale Tecchio 80, 80125 Naples, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024553570"],"corresponding_institution_ids":["https://openalex.org/I4210155236"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":1.6176,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.80175411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"100A","issue":"8","first_page":"2063","last_page":"2070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/injectable-bone-substitute","display_name":"injectable bone substitute","score":0.9559999704360962},{"id":"https://openalex.org/keywords/organic-inorganic-hybrid-materials","display_name":"organic-inorganic hybrid materials","score":0.6759999990463257},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nanocrystalline-hydroxyapatite","display_name":"nanocrystalline hydroxyapatite","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nano-hydroxyapatite","display_name":"hydroxyapatite nanoparticles","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sol-gel-synthesis","display_name":"sol-gel synthesis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/phase-transition-kinetics","display_name":"phase transition kinetics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/rheology","display_name":"rheology","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.8936903476715088},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.5756688714027405},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.5491547584533691},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5073868632316589},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.5000388622283936},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46254417300224304},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.44021403789520264},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.42098450660705566},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.4023182988166809},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.326119065284729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013052","descriptor_name":"Spectrometry, X-Ray Emission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013818","descriptor_name":"Thermogravimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.34112","doi":"https://doi.org/10.1002/jbm.a.34112","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.34112","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:22581691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22581691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W182841434","https://openalex.org/W184359204","https://openalex.org/W194566379","https://openalex.org/W1555194482","https://openalex.org/W1963987683","https://openalex.org/W1964484523","https://openalex.org/W1972906016","https://openalex.org/W1977876757","https://openalex.org/W1983440780","https://openalex.org/W1984775053","https://openalex.org/W1986170848","https://openalex.org/W1986424611","https://openalex.org/W1986792838","https://openalex.org/W1993447012","https://openalex.org/W2001143202","https://openalex.org/W2006974802","https://openalex.org/W2009374950","https://openalex.org/W2009457955","https://openalex.org/W2011729352","https://openalex.org/W2016868548","https://openalex.org/W2023970479","https://openalex.org/W2026050752","https://openalex.org/W2028221506","https://openalex.org/W2028548404","https://openalex.org/W2030862533","https://openalex.org/W2032590953","https://openalex.org/W2033592468","https://openalex.org/W2043049240","https://openalex.org/W2043938559","https://openalex.org/W2049240089","https://openalex.org/W2050582815","https://openalex.org/W2051805427","https://openalex.org/W2052801240","https://openalex.org/W2053497293","https://openalex.org/W2058752126","https://openalex.org/W2063534531","https://openalex.org/W2065571904","https://openalex.org/W2068093124","https://openalex.org/W2083521117","https://openalex.org/W2085005040","https://openalex.org/W2088697330","https://openalex.org/W2091466037","https://openalex.org/W2094424086","https://openalex.org/W2114467139","https://openalex.org/W2120101633","https://openalex.org/W2133827874","https://openalex.org/W2153034104","https://openalex.org/W2181507525","https://openalex.org/W2497371428"],"related_works":["https://openalex.org/W7064967998","https://openalex.org/W2805111668","https://openalex.org/W1987460218","https://openalex.org/W2589371168","https://openalex.org/W2076888350","https://openalex.org/W2593098949","https://openalex.org/W4245411753","https://openalex.org/W4388827670","https://openalex.org/W4386318828","https://openalex.org/W4213454318"],"abstract_inverted_index":{"Injectable":[0],"bone":[1,136],"substitutes":[2],"are":[3],"rapidly":[4],"gained":[5],"success":[6],"in":[7,138],"tissue":[8],"engineering":[9],"applications":[10],"for":[11],"their":[12],"less":[13],"invasive":[14],"surgical":[15],"aspect.":[16],"Here,":[17],"the":[18,21,58,66,72,87,91,105,119,128],"design":[19],"and":[20,52,60,74,81,114],"characterization":[22],"of":[23,28,33,57,68,90,93,122],"a":[24],"novel":[25],"degradable":[26],"paste":[27,61,92,107,130],"PCL":[29],"reinforced":[30],"with":[31,118],"nanocrystals":[32],"hydroxyapatite":[34],"have":[35],"been":[36,45],"presented":[37],"aiming":[38],"to":[39,64],"mimic":[40],"natural":[41],"tissue.":[42],"Nanohydroxyapatite":[43],"has":[44],"successfully":[46],"synthesized":[47],"via":[48,78],"sol-gel":[49],"technique.":[50],"Dynamic":[51],"steady":[53],"state":[54],"viscoelastic":[55],"properties":[56],"solutions":[59],"were":[62,76],"investigated":[63],"control":[65],"kinetic":[67],"phase":[69],"transition.":[70],"Correspondingly,":[71],"morphology":[73],"composition":[75],"characterized":[77],"TEM,":[79],"EDAX,":[80],"thermal":[82],"analysis.":[83],"Injection":[84],"test":[85],"underlines":[86],"completely":[88],"ability":[89],"being":[94],"injected":[95],"without":[96],"altering":[97],"its":[98],"features.":[99],"Preliminary":[100],"biological":[101,115],"study":[102],"showed":[103],"that":[104,127],"composite":[106,129],"is":[108,131],"not":[109],"cytotoxic.":[110],"The":[111],"synergistic":[112],"rheological":[113],"properties,":[116],"combined":[117],"positive":[120],"effect":[121],"chemical":[123],"synthesis":[124],"method":[125],"indicate":[126],"very":[132],"suitable":[133],"as":[134],"local":[135],"substitute":[137],"low-load":[139],"areas.":[140]},"counts_by_year":[{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}