{"id":"https://openalex.org/W1977434331","doi":"https://doi.org/10.1016/j.jemermed.2008.06.021","title":"C-Reactive Protein Testing Does Not Decrease Antibiotic Use for Acute Cough Illness When Compared to a Clinical Algorithm","display_name":"C-Reactive Protein Testing Does Not Decrease Antibiotic Use for Acute Cough Illness When Compared to a Clinical Algorithm","publication_year":2008,"publication_date":"2008-12-18","ids":{"openalex":"https://openalex.org/W1977434331","doi":"https://doi.org/10.1016/j.jemermed.2008.06.021","mag":"1977434331","pmid":"https://pubmed.ncbi.nlm.nih.gov/19095403"},"language":"en","primary_location":{"id":"doi:10.1016/j.jemermed.2008.06.021","doi":"https://doi.org/10.1016/j.jemermed.2008.06.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jemermed.2008.06.021","pdf_url":null,"source":{"id":"https://openalex.org/S4210219855","display_name":"Journal of Emergency Medicine","issn_l":"0736-4679","issn":["0736-4679","1090-1280","2352-5029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Emergency Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068464329","display_name":"Ralph Gonzales","orcid":"https://orcid.org/0000-0002-6061-7219","observed_orcids":["https://orcid.org/0000-0002-6061-7219"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralph Gonzales","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, San Francisco, California 94118, USA","Department of Medicine University of California, San Francisco  San Francisco California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, San Francisco, California 94118, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine University of California, San Francisco  San Francisco California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080764219","display_name":"Eva Aagaard","orcid":"https://orcid.org/0000-0002-5773-0923","observed_orcids":["https://orcid.org/0000-0002-5773-0923"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva M. Aagaard","raw_affiliation_strings":["Department of Medicine, University of Colorado and Denver and Health Sciences Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado and Denver and Health Sciences Center, Denver, Colorado","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062152763","display_name":"Carlos A. Camargo","orcid":"https://orcid.org/0000-0002-5071-7654","observed_orcids":["https://orcid.org/0000-0002-5071-7654"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Camargo","raw_affiliation_strings":["Department of Emergency Medicine, Massachussetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachussetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"O. John Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. John Ma","raw_affiliation_strings":["Department of Emergency Medicine, Oregon Health and Sciences University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Oregon Health and Sciences University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001986516","display_name":"Mark W. Plautz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210154663","display_name":"Kansas City VA Medical Center","ror":"https://ror.org/050mdr969","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210154663","https://openalex.org/I4210165236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Plautz","raw_affiliation_strings":["Veterans Affairs Medical Center, Medicine Service (111), Kansas City, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center, Medicine Service (111), Kansas City, Missouri","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210154663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083583070","display_name":"Judith H. Maselli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith H. Maselli","raw_affiliation_strings":["Department of Medicine University of California, San Francisco  San Francisco California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of California, San Francisco  San Francisco California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009449264","display_name":"Charles E. McCulloch","orcid":"https://orcid.org/0000-0002-1279-6179","observed_orcids":["https://orcid.org/0000-0002-1279-6179"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. McCulloch","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001234354","display_name":"Sara K. Levin","orcid":"https://orcid.org/0000-0002-8912-6915","observed_orcids":["https://orcid.org/0000-0002-8912-6915"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara K. Levin","raw_affiliation_strings":["Department of Medicine University of California, San Francisco  San Francisco California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine University of California, San Francisco  San Francisco California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031166034","display_name":"Joshua P. Metlay","orcid":"https://orcid.org/0000-0003-2259-6282","observed_orcids":["https://orcid.org/0000-0003-2259-6282"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua P. Metlay","raw_affiliation_strings":["VA Medical Center, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Medical Center, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5068464329"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":2.2251,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.87419123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"1","first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13555","display_name":"Healthcare cost, quality, practices","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11095","display_name":"Emergency and Acute Care Studies","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9480000138282776},{"id":"https://openalex.org/keywords/acute-cough","display_name":"acute cough","score":0.9129999876022339},{"id":"https://openalex.org/keywords/overuse-of-antibiotics","display_name":"antibiotic overuse","score":0.7710000276565552},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.9129999876022339},{"id":"https://openalex.org/keywords/emergency-department-care","display_name":"emergency department care","score":0.6430000066757202},{"id":"https://openalex.org/keywords/chest-x-ray","display_name":"chest radiography","score":0.7889999747276306},{"id":"https://openalex.org/keywords/clinical-algorithms","display_name":"clinical algorithms","score":0.7760000228881836},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.580787718296051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.553722083568573},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5523934960365295},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43875184655189514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39320117235183716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20226967334747314},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16339874267578125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12484854459762573}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004636","descriptor_name":"Emergency Service, Hospital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006786","descriptor_name":"Hospitals, Urban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jemermed.2008.06.021","doi":"https://doi.org/10.1016/j.jemermed.2008.06.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jemermed.2008.06.021","pdf_url":null,"source":{"id":"https://openalex.org/S4210219855","display_name":"Journal of Emergency Medicine","issn_l":"0736-4679","issn":["0736-4679","1090-1280","2352-5029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Emergency Medicine","raw_type":"journal-article"},{"id":"pmid:19095403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19095403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of emergency medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4141310999","display_name":null,"funder_award_id":"1 R01 HS013915","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1975555110","https://openalex.org/W1988639477","https://openalex.org/W1989096110","https://openalex.org/W1989951598","https://openalex.org/W1995444045","https://openalex.org/W2038692466","https://openalex.org/W2047241255","https://openalex.org/W2062316742","https://openalex.org/W2072284843","https://openalex.org/W2088914278","https://openalex.org/W2096133312","https://openalex.org/W2098773908","https://openalex.org/W2105249258","https://openalex.org/W2107707046","https://openalex.org/W2119068637","https://openalex.org/W2124984339","https://openalex.org/W2151087371","https://openalex.org/W2157522234","https://openalex.org/W2166907962"],"related_works":["https://openalex.org/W2611905865","https://openalex.org/W2413856645","https://openalex.org/W2160756794","https://openalex.org/W2405412126","https://openalex.org/W2957912127","https://openalex.org/W2121093175","https://openalex.org/W4251468399","https://openalex.org/W2413757829","https://openalex.org/W3097420698","https://openalex.org/W2263984621"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}