{"id":"https://openalex.org/W1977375280","doi":"https://doi.org/10.1021/jm051229y","title":"Identification of Compounds with Anti-West Nile Virus Activity","display_name":"Identification of Compounds with Anti-West Nile Virus Activity","publication_year":2006,"publication_date":"2006-02-24","ids":{"openalex":"https://openalex.org/W1977375280","doi":"https://doi.org/10.1021/jm051229y","mag":"1977375280","pmid":"https://pubmed.ncbi.nlm.nih.gov/16539402"},"language":"en","primary_location":{"id":"doi:10.1021/jm051229y","doi":"https://doi.org/10.1021/jm051229y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm051229y","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027331467","display_name":"John R. Goodell","orcid":"https://orcid.org/0000-0001-8951-7804","observed_orcids":["https://orcid.org/0000-0001-8951-7804"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Goodell","raw_affiliation_strings":["Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032017679","display_name":"Francesc Puig\u2010Basagoiti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesc Puig-Basagoiti","raw_affiliation_strings":["Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001621230","display_name":"Brett M. Forshey","orcid":"https://orcid.org/0000-0001-9188-2720","observed_orcids":["https://orcid.org/0000-0001-9188-2720"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett M. Forshey","raw_affiliation_strings":["Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057764651","display_name":"Pei\u2010Yong Shi","orcid":"https://orcid.org/0000-0001-5553-1616","observed_orcids":["https://orcid.org/0000-0001-5553-1616"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pei-Yong Shi","raw_affiliation_strings":["Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078796555","display_name":"David M. Ferguson","orcid":"https://orcid.org/0000-0001-6294-8057","observed_orcids":["https://orcid.org/0000-0001-6294-8057"]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Ferguson","raw_affiliation_strings":["Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, and Wadsworth Center, New York State Department of Health, Albany, New York 12208","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057764651","https://openalex.org/A5078796555"],"corresponding_institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I130238516","https://openalex.org/I1339417872"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":10.9957,"has_fulltext":false,"cited_by_count":137,"citation_normalized_percentile":{"value":0.9877204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"49","issue":"6","first_page":"2127","last_page":"2137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.949999988079071},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.781000018119812},{"id":"https://openalex.org/keywords/pyrazolines","display_name":"pyrazolines","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acridine","display_name":"acridine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/quinoline","display_name":"quinoline","score":1.0},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7699999809265137},{"id":"https://openalex.org/keywords/viral-rna-synthesis-inhibition","display_name":"viral RNA synthesis inhibition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/viral-replication-mechanism","display_name":"viral replication mechanism","score":0.6769999861717224},{"id":"https://openalex.org/keywords/high-throughput-screening-hits","display_name":"high-throughput screening hits","score":0.6489999890327454},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6235814690589905},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.6133785843849182},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.5796306729316711},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.556881844997406},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5374501347541809},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5218507051467896},{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.5198310017585754},{"id":"https://openalex.org/C2780744904","wikidata":"https://www.wikidata.org/wiki/Q7263415","display_name":"Pyrazoline","level":2,"score":0.5088715553283691},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.508621335029602},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.49511709809303284},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.4585968255996704},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.395589679479599},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3647578954696655},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35358166694641113},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3142821192741394},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.2832292914390564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2519955635070801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23462802171707153},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1734098196029663},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11507877707481384},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm051229y","doi":"https://doi.org/10.1021/jm051229y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm051229y","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:16539402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16539402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5389312166","display_name":"Identifying inhibitors of West Nile and dengue viruses","funder_award_id":"U01AI061193","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6961562556","display_name":null,"funder_award_id":"AI061193","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1983863966","https://openalex.org/W1993098170","https://openalex.org/W2016635319","https://openalex.org/W2025023091","https://openalex.org/W2047382578","https://openalex.org/W2048699176","https://openalex.org/W2051514752","https://openalex.org/W2060109807","https://openalex.org/W2062820605","https://openalex.org/W2071749695","https://openalex.org/W2073156286","https://openalex.org/W2076611050","https://openalex.org/W2095613131","https://openalex.org/W2097289915","https://openalex.org/W2148741876","https://openalex.org/W2315546268","https://openalex.org/W2318565229","https://openalex.org/W2949698461","https://openalex.org/W2950469730"],"related_works":["https://openalex.org/W2002073253","https://openalex.org/W1988921312","https://openalex.org/W2155960699","https://openalex.org/W2110329144","https://openalex.org/W4321764300","https://openalex.org/W4414536531","https://openalex.org/W4281748144","https://openalex.org/W2048699176","https://openalex.org/W7147262275","https://openalex.org/W2109789695"],"abstract_inverted_index":{"The":[0,58,113,144],"lack":[1],"of":[2,14,40,61,81,111,130,184,221],"antiviral":[3],"compounds":[4,45,89,114],"targeting":[5],"flaviviruses":[6],"represents":[7],"a":[8,119,180],"significant":[9],"problem":[10],"in":[11,33,118,171],"the":[12,38,79,128,134,147,173,194,204,214,217],"development":[13,220],"strategies":[15],"for":[16,176,198,216],"treating":[17],"West":[18],"Nile":[19],"Virus":[20],"(WNV),":[21],"Dengue,":[22],"and":[23,56,76,84,95,219],"Yellow":[24],"Fever":[25],"infections.":[26],"Using":[27],"WNV":[28,207],"high-throughput":[29],"screening":[30],"techniques":[31],"developed":[32],"our":[34],"laboratories,":[35],"we":[36],"report":[37],"identification":[39],"several":[41],"small":[42],"molecule":[43],"anti-WNV":[44],"belonging":[46],"to":[47,70,97,124,153,211],"four":[48],"different":[49],"structural":[50,174],"classes":[51],"including":[52],"pyrazolines,":[53],"xanthanes,":[54],"acridines,":[55],"quinolines.":[57],"initial":[59],"set":[60],"\"hits\"":[62],"was":[63,168],"further":[64,116],"refined":[65],"using":[66,100],"cell":[67],"viability-cytotoxicity":[68],"assays":[69],"two":[71],"1,3,5-triaryl":[72],"pyrazoline":[73],"compounds:":[74],"1-(4-chlorophenylacetyl)-5-(4-nitrophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole":[75],"1-benzoyl-5-(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole.":[77],"On":[78],"basis":[80],"their":[82],"activity":[83,177,199,208],"favorable":[85],"therapeutic":[86],"indexes,":[87],"these":[88],"were":[90,115],"identified":[91],"as":[92,164],"viable":[93],"leads":[94],"subjected":[96],"additional":[98],"evaluation":[99],"an":[101,108],"authentic":[102],"viral":[103,142,154,161],"titer":[104],"reduction":[105],"assay":[106],"employing":[107],"epidemic":[109],"strain":[110],"WNV.":[112,201],"evaluated":[117],"transient":[120],"replicon":[121],"reporting":[122],"system":[123],"gain":[125],"insight":[126],"into":[127],"mechanism":[129],"action":[131],"by":[132,178],"identifying":[133],"step":[135],"at":[136],"which":[137],"inhibition":[138],"takes":[139],"place":[140],"during":[141],"replication.":[143],"results":[145,205],"indicate":[146,206],"pyrazolines":[148],"inhibit":[149],"RNA":[150,155,157],"synthesis,":[151],"pointing":[152],"polymerase,":[156],"helicase,":[158],"or":[159],"other":[160],"replication":[162],"enzymes":[163],"potential":[165],"targets.":[166],"Progress":[167],"also":[169],"made":[170],"understanding":[172],"requirements":[175],"synthesizing":[179],"focused":[181],"chemical":[182],"library":[183],"substituted":[185],"pyrazolines.":[186],"Preliminary":[187],"SAR":[188],"data":[189],"are":[190,196],"presented":[191],"that":[192],"show":[193],"aryl-rings":[195],"required":[197],"against":[200],"More":[202],"importantly,":[203],"is":[209],"tolerant":[210],"aryl-substitutions":[212],"paving":[213],"way":[215],"design":[218],"much":[222],"larger":[223],"combinatorial":[224],"libraries":[225],"with":[226],"varied":[227],"physicochemical":[228],"properties.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
