{"id":"https://openalex.org/W1977366125","doi":"https://doi.org/10.1371/journal.pone.0099810","title":"Molecular Approaches for Detection of the Multi-Drug Resistant Tuberculosis (MDR-TB) in Bangladesh","display_name":"Molecular Approaches for Detection of the Multi-Drug Resistant Tuberculosis (MDR-TB) in Bangladesh","publication_year":2014,"publication_date":"2014-06-16","ids":{"openalex":"https://openalex.org/W1977366125","doi":"https://doi.org/10.1371/journal.pone.0099810","mag":"1977366125","pmid":"https://pubmed.ncbi.nlm.nih.gov/24932706","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4059658"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0099810","doi":"https://doi.org/10.1371/journal.pone.0099810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099810&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015634726","display_name":"Tafsina Haque Aurin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32883739","display_name":"Stamford University Bangladesh","ror":"https://ror.org/0441jdk54","country_code":"BD","type":"education","lineage":["https://openalex.org/I32883739"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tafsina Haque Aurin","raw_affiliation_strings":["Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I32883739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038054871","display_name":"Saurab Kishore Munshi","orcid":"https://orcid.org/0000-0003-3950-7741","observed_orcids":["https://orcid.org/0000-0003-3950-7741"]},"institutions":[{"id":"https://openalex.org/I32883739","display_name":"Stamford University Bangladesh","ror":"https://ror.org/0441jdk54","country_code":"BD","type":"education","lineage":["https://openalex.org/I32883739"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Saurab Kishore Munshi","raw_affiliation_strings":["Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I32883739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076671221","display_name":"S. M. Mostofa Kamal","orcid":"https://orcid.org/0000-0003-4439-0752","observed_orcids":["https://orcid.org/0000-0003-4439-0752"]},"institutions":[{"id":"https://openalex.org/I4405267824","display_name":"National Institute of Diseases of the Chest and Hospital","ror":"https://ror.org/04j8m8490","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I4405267824"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"S. M. Mostofa Kamal","raw_affiliation_strings":["National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4405267824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103558634","display_name":"Md. Mostafizur Rahman","orcid":"https://orcid.org/0009-0006-5476-2600","observed_orcids":["https://orcid.org/0009-0006-5476-2600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md. Mostafizur Rahman","raw_affiliation_strings":["University Research Co., LLC (URC), Banani, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Research Co., LLC (URC), Banani, Dhaka, Bangladesh","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103399457","display_name":"Md. Shamim Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267824","display_name":"National Institute of Diseases of the Chest and Hospital","ror":"https://ror.org/04j8m8490","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I4405267824"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Shamim Hossain","raw_affiliation_strings":["National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4405267824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028492941","display_name":"Thaythayhla Marma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267824","display_name":"National Institute of Diseases of the Chest and Hospital","ror":"https://ror.org/04j8m8490","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I4405267824"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Thaythayhla Marma","raw_affiliation_strings":["National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Tuberculosis Reference Laboratory (NTRL), NIDCH, Mohakhali, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4405267824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902775","display_name":"Farjana Rahman","orcid":"https://orcid.org/0009-0006-3113-9015","observed_orcids":["https://orcid.org/0009-0006-3113-9015"]},"institutions":[{"id":"https://openalex.org/I32883739","display_name":"Stamford University Bangladesh","ror":"https://ror.org/0441jdk54","country_code":"BD","type":"education","lineage":["https://openalex.org/I32883739"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Farjana Rahman","raw_affiliation_strings":["Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I32883739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052913158","display_name":"Rashed Noor","orcid":"https://orcid.org/0000-0003-4837-221X","observed_orcids":["https://orcid.org/0000-0003-4837-221X"]},"institutions":[{"id":"https://openalex.org/I32883739","display_name":"Stamford University Bangladesh","ror":"https://ror.org/0441jdk54","country_code":"BD","type":"education","lineage":["https://openalex.org/I32883739"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Rashed Noor","raw_affiliation_strings":["Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Stamford University Bangladesh, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I32883739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052913158"],"corresponding_institution_ids":["https://openalex.org/I32883739"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.5408,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.92852365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"e99810","last_page":"e99810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/molecular-detection-of-drug-resistance","display_name":"molecular detection of drug resistance","score":0.7149999737739563},{"id":"https://openalex.org/keywords/line-probe-assay","display_name":"line probe assay","score":0.9800000190734863},{"id":"https://openalex.org/keywords/xpert-mtb-rif","display_name":"Xpert MTB/RIF","score":0.984000027179718},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/isoniazid-resistance","display_name":"isoniazid resistance","score":1.0},{"id":"https://openalex.org/keywords/rpob-mutations","display_name":"rpoB mutations","score":0.906000018119812},{"id":"https://openalex.org/keywords/inha-mutations","display_name":"inhA mutations","score":0.9380000233650208},{"id":"https://openalex.org/keywords/katg-mutations","display_name":"katG mutations","score":1.0},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C126265401","wikidata":"https://www.wikidata.org/wiki/Q295544","display_name":"GeneXpert MTB/RIF","level":4,"score":0.769435703754425},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.7295988202095032},{"id":"https://openalex.org/C2780687663","wikidata":"https://www.wikidata.org/wiki/Q18027924","display_name":"INHA","level":4,"score":0.6859305500984192},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.6762938499450684},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6628482341766357},{"id":"https://openalex.org/C2778340795","wikidata":"https://www.wikidata.org/wiki/Q24782946","display_name":"rpoB","level":4,"score":0.6340763568878174},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5787820816040039},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.5683013796806335},{"id":"https://openalex.org/C2777107064","wikidata":"https://www.wikidata.org/wiki/Q1040214","display_name":"Extensively drug-resistant tuberculosis","level":4,"score":0.5201966166496277},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.508820116519928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079506039619446},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46919935941696167},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45584315061569214},{"id":"https://openalex.org/C2777025531","wikidata":"https://www.wikidata.org/wiki/Q866602","display_name":"Multi-drug-resistant tuberculosis","level":4,"score":0.4545811712741852},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4108564853668213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3123038709163666},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2917259633541107},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25472182035446167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13618847727775574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07685548067092896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07291862368583679}],"mesh":[{"descriptor_ui":"D001459","descriptor_name":"Bangladesh","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0099810","doi":"https://doi.org/10.1371/journal.pone.0099810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3036521","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4059658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24932706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24932706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4059658","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4059658/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.776.3445","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.776.3445","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f5/a9/pone.0099810.PMC4059658.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:84631249efb24d61981cf0723faf7b9e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/84631249efb24d61981cf0723faf7b9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e99810 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0099810","doi":"https://doi.org/10.1371/journal.pone.0099810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0099810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977366125.pdf","grobid_xml":"https://content.openalex.org/works/W1977366125.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W70238687","https://openalex.org/W248245953","https://openalex.org/W1608774334","https://openalex.org/W1643675866","https://openalex.org/W1985983285","https://openalex.org/W2001681951","https://openalex.org/W2037084195","https://openalex.org/W2038010814","https://openalex.org/W2050688039","https://openalex.org/W2052422622","https://openalex.org/W2055121465","https://openalex.org/W2059285476","https://openalex.org/W2073319399","https://openalex.org/W2076172073","https://openalex.org/W2084907207","https://openalex.org/W2093367270","https://openalex.org/W2093766061","https://openalex.org/W2108234063","https://openalex.org/W2109454960","https://openalex.org/W2112022845","https://openalex.org/W2112389217","https://openalex.org/W2114658413","https://openalex.org/W2118461432","https://openalex.org/W2120238788","https://openalex.org/W2120595078","https://openalex.org/W2121765841","https://openalex.org/W2125179847","https://openalex.org/W2129341611","https://openalex.org/W2135014449","https://openalex.org/W2140892120","https://openalex.org/W2150843895","https://openalex.org/W2153385431","https://openalex.org/W2153877499","https://openalex.org/W2154491836","https://openalex.org/W2161140573","https://openalex.org/W2163683100","https://openalex.org/W2164341034","https://openalex.org/W2166766518","https://openalex.org/W2167328683","https://openalex.org/W2168848141","https://openalex.org/W2170095570","https://openalex.org/W2321815173","https://openalex.org/W2401956843","https://openalex.org/W3146264547"],"related_works":["https://openalex.org/W2119541468","https://openalex.org/W6930752384","https://openalex.org/W2662717356","https://openalex.org/W1548054625","https://openalex.org/W2090724189","https://openalex.org/W2984765888","https://openalex.org/W7166561819","https://openalex.org/W3176219757","https://openalex.org/W4401976984","https://openalex.org/W2949473602"],"abstract_inverted_index":{"The":[0],"principal":[1],"obstacles":[2],"in":[3,100,155,205,209,277,282],"the":[4,18,21,28,32,37,57,73,95,101,132,135,175,199,249,257,267],"treatment":[5,30],"of":[6,20,31,39,46,59,63,75,86,97,134,165,237,269],"tuberculosis":[7],"(TB)":[8],"are":[9],"delayed":[10],"and":[11,34,43,68,88,107,115,144,157,180,191,207,214,226,231,245,253,271],"inaccurate":[12],"diagnosis":[13],"which":[14],"often":[15],"leads":[16],"to":[17,35,55,130,150,219,241,260],"onset":[19],"drug":[22,122,193,200,238,279],"resistant":[23,47,77,152,201,280],"TB":[24,90,281],"cases.":[25,247],"To":[26],"avail":[27],"appropriate":[29],"patients":[33,233],"hinder":[36],"transmission":[38],"drug-resistant":[40],"TB,":[41],"accurate":[42],"rapid":[44],"detection":[45,74,96],"isolates":[48,183,202],"is":[49],"critical.":[50],"Present":[51],"study":[52,265],"was":[53,126],"designed":[54],"demonstrate":[56],"efficacy":[58,133],"molecular":[60,136],"techniques":[61],"inclusive":[62],"line":[64],"probe":[65],"assay":[66,112,273],"(LPA)":[67],"GeneXpert":[69,116,158,272],"MTB/RIF":[70,117],"methods":[71,137],"for":[72,94],"multi-drug":[76],"(MDR)":[78],"TB.":[79],"Sputum":[80],"samples":[81],"from":[82,243],"300":[83,140],"different":[84],"categories":[85],"treated":[87],"new":[89,246],"cases":[91,147,164],"were":[92,148,168,217],"tested":[93],"possible":[98],"mutation":[99],"resistance":[102,167,186,239],"specific":[103],"genes":[104],"(rpoB,":[105],"inhA":[106],"katG)":[108],"through":[109],"Genotype":[110],"MTBDRplus":[111],"or":[113],"LPA":[114,156,190,206,225,270],"tests.":[118],"Culture":[119],"based":[120],"conventional":[121,171,192,210,227],"susceptibility":[123,194],"test":[124,195],"(DST)":[125],"also":[127],"carried":[128],"out":[129],"measure":[131],"employed.":[138],"Among":[139,198],"samples,":[141],"191":[142,181],"(63.7%)":[143,182],"193":[145,208],"(64.3%)":[146],"found":[149],"be":[151,220],"against":[153],"rifampicin":[154,166],"methods,":[159],"respectively;":[160],"while":[161],"189":[162,212],"(63%)":[163],"detected":[169,188],"by":[170,189,224],"DST":[172],"methods.":[173],"On":[174],"other":[176],"hand,":[177],"196":[178],"(65.3%)":[179],"showed":[184],"isoniazid":[185],"as":[187,222,274],"(DST),":[196],"respectively.":[197,229],"(collectively":[203],"198":[204],"DST),":[211],"(95.6%)":[213],"187":[215],"(96.9%)":[216],"considered":[218],"MDR":[221],"examined":[223],"DST,":[228],"Category-II":[230],"-IV":[232],"encountered":[234],"higher":[235,250],"frequency":[236],"compared":[240],"those":[242],"category-I":[244],"Considering":[248],"sensitivity,":[251],"specificity":[252],"accuracy":[254],"along":[255],"with":[256],"required":[258],"time":[259],"results":[261],"significantly":[262],"shorter,":[263],"our":[264],"supports":[266],"adoption":[268],"efficient":[275],"tools":[276],"detecting":[278],"Bangladesh.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}