{"id":"https://openalex.org/W1977347101","doi":"https://doi.org/10.1126/science.183.4124.539","title":"Apomorphine: Modification of Its Hyperthermic Effect in Rabbits byp-Chlorophenylalanine","display_name":"Apomorphine: Modification of Its Hyperthermic Effect in Rabbits byp-Chlorophenylalanine","publication_year":1974,"publication_date":"1974-02-08","ids":{"openalex":"https://openalex.org/W1977347101","doi":"https://doi.org/10.1126/science.183.4124.539","mag":"1977347101","pmid":"https://pubmed.ncbi.nlm.nih.gov/4272136"},"language":"en","primary_location":{"id":"doi:10.1126/science.183.4124.539","doi":"https://doi.org/10.1126/science.183.4124.539","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.183.4124.539","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015469925","display_name":"Raymond Mark Quock","orcid":"https://orcid.org/0000-0001-6616-4778","observed_orcids":["https://orcid.org/0000-0001-6616-4778"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. M. Quock","raw_affiliation_strings":["Department of Pharmacology, University of Washington, School of Medicine, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, School of Medicine, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108388623","display_name":"A. Horita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Horita","raw_affiliation_strings":["Department of Pharmacology, University of Washington, School of Medicine, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, School of Medicine, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":1.7041,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81660495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"183","issue":"4124","first_page":"539","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":1.0},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8289999961853027},{"id":"https://openalex.org/keywords/p-chlorophenylalanine","display_name":"p-chlorophenylalanine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.7549999952316284},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/decarboxylase-inhibition","display_name":"decarboxylase inhibition","score":0.7839999794960022},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.8539999723434448},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/serotonin-uptake","display_name":"serotonin uptake","score":0.4009999930858612},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.8268880844116211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4712146818637848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4556248188018799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41017013788223267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27665579319000244},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.19637641310691833},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010134","descriptor_name":"Fenclonine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.183.4124.539","doi":"https://doi.org/10.1126/science.183.4124.539","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.183.4124.539","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:4272136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4272136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1982564146","https://openalex.org/W1989702866","https://openalex.org/W1993160794","https://openalex.org/W2013718093","https://openalex.org/W2067532033","https://openalex.org/W2070416508","https://openalex.org/W2092145492","https://openalex.org/W2141376446","https://openalex.org/W2149330955","https://openalex.org/W2163612179","https://openalex.org/W2260661700","https://openalex.org/W2400305881"],"related_works":["https://openalex.org/W2434445954","https://openalex.org/W2094884357","https://openalex.org/W2033538413","https://openalex.org/W2077363043","https://openalex.org/W2083351764","https://openalex.org/W2027135413","https://openalex.org/W2042612675","https://openalex.org/W2112531321","https://openalex.org/W2291291429","https://openalex.org/W2070416508"],"abstract_inverted_index":{"The":[0,47,66],"hyperthermic":[1,39,86],"response":[2,40],"of":[3,33,49,56,69,78,88,95],"rabbits":[4,52,91],"to":[5,41,72],"apomorphine,":[6],"a":[7,24],"dopaminergic":[8],"agonist,":[9],"is":[10,43,82],"abolished":[11],"by":[12],"prior":[13],"treatment":[14],"with":[15,53],"p-chlorophenylalanine.":[16],"If":[17],"such":[18],"5-hydroxytryptamine":[19],"(5-HT)-depleted":[20],"animals":[21,79],"are":[22,35,58],"administered":[23],"peripherally":[25],"acting":[26],"decarboxylase":[27],"inhibitor":[28],"plus":[29],"5-hydroxytryptophan,":[30],"central":[31],"stores":[32],"5-HT":[34,57],"regenerated":[36],"and":[37],"the":[38,85,93],"apomorphine":[42,50,89],"restored":[44],"in":[45,51,63,75,90],"part.":[46],"effects":[48,68,87],"elevated":[54],"concentrations":[55],"not":[59],"different":[60],"from":[61],"those":[62],"control":[64],"animals.":[65],"behavioral":[67],"apomnorphine":[70],"appear":[71],"be":[73],"constant":[74],"all":[76],"groups":[77],"tested.":[80],"It":[81],"suggested":[83],"that":[84],"require":[92],"presence":[94],"5-HT.":[96]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
