{"id":"https://openalex.org/W1977345158","doi":"https://doi.org/10.1073/pnas.92.24.11312","title":"Inhibition of ascorbate peroxidase by salicylic acid and 2,6-dichloroisonicotinic acid, two inducers of plant defense responses.","display_name":"Inhibition of ascorbate peroxidase by salicylic acid and 2,6-dichloroisonicotinic acid, two inducers of plant defense responses.","publication_year":1995,"publication_date":"1995-11-21","ids":{"openalex":"https://openalex.org/W1977345158","doi":"https://doi.org/10.1073/pnas.92.24.11312","mag":"1977345158","pmid":"https://pubmed.ncbi.nlm.nih.gov/7479986","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/40622"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.24.11312","doi":"https://doi.org/10.1073/pnas.92.24.11312","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.92.24.11312","pdf_url":"https://www.pnas.org/content/pnas/92/24/11312.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/92/24/11312.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045214558","display_name":"J\u00f6rg Durner","orcid":"https://orcid.org/0000-0003-4436-4415","observed_orcids":["https://orcid.org/0000-0003-4436-4415"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Durner","raw_affiliation_strings":["Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072682373","display_name":"Daniel F. Klessig","orcid":"https://orcid.org/0000-0002-1315-5920","observed_orcids":["https://orcid.org/0000-0002-1315-5920"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D F Klessig","raw_affiliation_strings":["Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA","University of California, Davis, CA,","Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, P.O. Box 759, Piscataway, NJ 08855"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"University of California, Davis, CA,","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, P.O. Box 759, Piscataway, NJ 08855","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.2905,"has_fulltext":true,"cited_by_count":420,"citation_normalized_percentile":{"value":0.99342666,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"92","issue":"24","first_page":"11312","last_page":"11316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascorbate-peroxidase","display_name":"ascorbate peroxidase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/salicylic-acid","display_name":"salicylic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/2-6-dichloroisonicotinic-acid","display_name":"2,6-dichloroisonicotinic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6510000228881836},{"id":"https://openalex.org/keywords/plant-defense-response","display_name":"plant defense response","score":0.8759999871253967},{"id":"https://openalex.org/keywords/catalase-inhibition","display_name":"catalase inhibition","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tobacco-mosaic-virus-resistance","display_name":"tobacco mosaic virus resistance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/guaiacol-peroxidase","display_name":"guaiacol peroxidase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.8489999771118164},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.746999979019165},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C130698151","wikidata":"https://www.wikidata.org/wiki/Q4653447","display_name":"APX","level":4,"score":0.9346468448638916},{"id":"https://openalex.org/C2780199054","wikidata":"https://www.wikidata.org/wiki/Q412403","display_name":"Guaiacol","level":3,"score":0.8824872970581055},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.849662184715271},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8265930414199829},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.6910518407821655},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6493973135948181},{"id":"https://openalex.org/C183570298","wikidata":"https://www.wikidata.org/wiki/Q2004252","display_name":"Plant defense against herbivory","level":3,"score":0.6426300406455994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.563158392906189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5384348034858704},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3023156523704529},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2627420723438263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06964218616485596},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0571826696395874}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007539","descriptor_name":"Isonicotinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020156","descriptor_name":"Salicylic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060387","descriptor_name":"Ascorbate Peroxidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.92.24.11312","doi":"https://doi.org/10.1073/pnas.92.24.11312","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.92.24.11312","pdf_url":"https://www.pnas.org/content/pnas/92/24/11312.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:7479986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7479986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:40622","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC40622/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.92.24.11312","doi":"https://doi.org/10.1073/pnas.92.24.11312","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.92.24.11312","pdf_url":"https://www.pnas.org/content/pnas/92/24/11312.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1107264721","display_name":"Characterization of the Salicylic Acid Signal Transduction  Pathway in Plant Defense Responses","funder_award_id":"9310371","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1977345158.pdf","grobid_xml":"https://content.openalex.org/works/W1977345158.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W82252971","https://openalex.org/W1528433521","https://openalex.org/W1568529372","https://openalex.org/W1628783271","https://openalex.org/W1956381307","https://openalex.org/W1964600118","https://openalex.org/W1988580531","https://openalex.org/W1997208169","https://openalex.org/W2001586790","https://openalex.org/W2006974547","https://openalex.org/W2007358741","https://openalex.org/W2012744796","https://openalex.org/W2021521164","https://openalex.org/W2024082951","https://openalex.org/W2039357309","https://openalex.org/W2044577862","https://openalex.org/W2047133043","https://openalex.org/W2059555945","https://openalex.org/W2059858570","https://openalex.org/W2061954020","https://openalex.org/W2078215181","https://openalex.org/W2084067481","https://openalex.org/W2091407682","https://openalex.org/W2092763049","https://openalex.org/W2092924111","https://openalex.org/W2099644089","https://openalex.org/W2100641812","https://openalex.org/W2128635872","https://openalex.org/W2129567631","https://openalex.org/W2147607421","https://openalex.org/W2153677512","https://openalex.org/W6600075554","https://openalex.org/W6603879240","https://openalex.org/W6639204077"],"related_works":["https://openalex.org/W2044577862","https://openalex.org/W2090826091","https://openalex.org/W1984675704","https://openalex.org/W2026965743","https://openalex.org/W2074649846","https://openalex.org/W2435883924","https://openalex.org/W2208320126","https://openalex.org/W2061954020","https://openalex.org/W2053149375","https://openalex.org/W2217228650"],"abstract_inverted_index":{"In":[0,84,158],"recent":[1],"years,":[2],"it":[3],"has":[4],"become":[5],"apparent":[6],"that":[7,26,51,203],"salicylic":[8],"acid":[9,72,91],"(SA)":[10],"plays":[11],"an":[12,79],"important":[13],"role":[14],"in":[15,39,127,167,209],"plant":[16],"defense":[17,69,180,205],"responses":[18,206],"to":[19,77,115,123,132,142,160],"pathogen":[20],"attack.":[21],"Previous":[22],"studies":[23],"have":[24],"suggested":[25],"one":[27],"of":[28,31,36,42,68,82,87,96,112,137,172,178,191,218],"SA's":[29],"mechanisms":[30],"action":[32],"is":[33],"the":[34,58,85,110,148,162,168,179,201,219],"inhibition":[35,190],"catalase,":[37],"resulting":[38],"elevated":[40,212],"levels":[41,214],"H2O2,":[43],"which":[44,165],"activate":[45],"defense-related":[46,125],"genes.":[47],"Here":[48],"we":[49],"demonstrate":[50],"SA":[52,105,113,140,186],"also":[53,75],"inhibits":[54],"ascorbate":[55],"peroxoidase":[56],"(APX),":[57],"other":[59],"key":[60],"enzyme":[61],"for":[62,104],"scavenging":[63],"H2O2.":[64],"The":[65,189],"synthetic":[66],"inducer":[67],"responses,":[70],"2,6-dichloroisonicotinic":[71],"(INA),":[73],"was":[74],"found":[76],"be":[78,143],"effective":[80],"inhibitor":[81],"APX.":[83],"presence":[86],"750":[88],"microM":[89,98,101],"ascorbic":[90],"(AsA),":[92],"substrate-dependent":[93],"IC50":[94],"values":[95],"78":[97],"and":[99,106,129,170,194],"95":[100],"were":[102],"obtained":[103],"INA,":[107],"respectively.":[108],"Furthermore,":[109],"ability":[111,122],"analogues":[114],"block":[116],"APX":[117,138],"activity":[118],"correlated":[119],"with":[120],"their":[121],"induce":[124],"genes":[126],"tobacco":[128,133],"enhance":[130],"resistance":[131],"mosaic":[134],"virus.":[135],"Inhibition":[136],"by":[139,152,185],"appears":[141],"reversible,":[144],"thus":[145],"differing":[146],"from":[147],"time-dependent,":[149],"irreversible":[150],"inactivation":[151],"suicide":[153],"substrates":[154],"such":[155],"as":[156,176],"p-aminophenol.":[157],"contrast":[159],"APX,":[161,195],"guaiacol-utilizing":[163],"peroxidases,":[164,199],"participate":[166],"synthesis":[169],"crosslinking":[171],"cell":[173],"wall":[174],"components":[175],"part":[177],"response,":[181],"are":[182,207],"not":[183,197],"inhibited":[184],"or":[187,215],"INA.":[188],"both":[192],"catalase":[193],"but":[196],"guaiacol":[198],"supports":[200],"hypothesis":[202],"SA-induced":[204],"mediated,":[208],"part,":[210],"through":[211],"H2O2":[213],"coupled":[216],"perturbations":[217],"cellular":[220],"redox":[221],"state.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
