{"id":"https://openalex.org/W1977258374","doi":"https://doi.org/10.2147/nedt.2007.3.2.185","title":"Role of pregabalin in the treatment of generalized anxiety disorder","display_name":"Role of pregabalin in the treatment of generalized anxiety disorder","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W1977258374","doi":"https://doi.org/10.2147/nedt.2007.3.2.185","mag":"1977258374","pmid":"https://pubmed.ncbi.nlm.nih.gov/19300552","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654626"},"language":"en","primary_location":{"id":"doi:10.2147/nedt.2007.3.2.185","doi":"https://doi.org/10.2147/nedt.2007.3.2.185","is_oa":false,"landing_page_url":"https://doi.org/10.2147/nedt.2007.3.2.185","pdf_url":null,"source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654626","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103137087","display_name":"David S. Baldwin","orcid":"https://orcid.org/0000-0003-3343-0907","observed_orcids":["https://orcid.org/0000-0003-3343-0907"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David S Baldwin","raw_affiliation_strings":["Clinical Neuroscience Division, University of Southampton, UK. dsb1@soton.ac.uk","Clinical Neuroscience Division, University of Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroscience Division, University of Southampton, UK. dsb1@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Clinical Neuroscience Division, University of Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074609886","display_name":"Khalil I. Ajel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802073232","display_name":"Southern Health NHS Foundation Trust","ror":"https://ror.org/03qesm017","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802073232"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Khalil Ajel","raw_affiliation_strings":["Clinical Neuroscience Division, University of Southampton, UK","Mood Disorders Service, Hampshire Partnership NHS Trust, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroscience Division, University of Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Mood Disorders Service, Hampshire Partnership NHS Trust, Southampton, UK","institution_ids":["https://openalex.org/I2802073232"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103137087"],"corresponding_institution_ids":["https://openalex.org/I43439940"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":null,"fwci":3.4164,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91266058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"185","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":1.0},{"id":"https://openalex.org/keywords/gaba-analogues","display_name":"GABA analogues","score":0.753000020980835},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.8759999871253967},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5289999842643738},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.75},{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/somatic-anxiety","display_name":"somatic anxiety","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9262250661849976},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8106553554534912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7887524366378784},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6688369512557983},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.6438890695571899},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6310815215110779},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6257488131523132},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4596651792526245},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4571083188056946},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3757999837398529},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3392634689807892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32091087102890015},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10318306088447571}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2147/nedt.2007.3.2.185","doi":"https://doi.org/10.2147/nedt.2007.3.2.185","is_oa":false,"landing_page_url":"https://doi.org/10.2147/nedt.2007.3.2.185","pdf_url":null,"source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},{"id":"pmid:19300552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19300552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric disease and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:62280","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/62280/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2654626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654626","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W99098873","https://openalex.org/W1917909847","https://openalex.org/W1966065460","https://openalex.org/W1966136822","https://openalex.org/W1970782429","https://openalex.org/W1972022767","https://openalex.org/W1973217171","https://openalex.org/W1979125626","https://openalex.org/W1982168366","https://openalex.org/W1982499183","https://openalex.org/W1985512018","https://openalex.org/W1992106585","https://openalex.org/W1998636853","https://openalex.org/W2005818204","https://openalex.org/W2018098567","https://openalex.org/W2022734113","https://openalex.org/W2027775387","https://openalex.org/W2034729631","https://openalex.org/W2040511339","https://openalex.org/W2047605192","https://openalex.org/W2054118318","https://openalex.org/W2060056442","https://openalex.org/W2075969573","https://openalex.org/W2080073833","https://openalex.org/W2084250730","https://openalex.org/W2107373225","https://openalex.org/W2114613490","https://openalex.org/W2116859990","https://openalex.org/W2132270420","https://openalex.org/W2147472478","https://openalex.org/W2151852296","https://openalex.org/W2152313268","https://openalex.org/W2160070901","https://openalex.org/W2160269874","https://openalex.org/W2160500602","https://openalex.org/W2162762176","https://openalex.org/W2169299701","https://openalex.org/W2312959127","https://openalex.org/W2746902415","https://openalex.org/W4205258863","https://openalex.org/W4251764539"],"related_works":["https://openalex.org/W3207609985","https://openalex.org/W4300171686","https://openalex.org/W1985615859","https://openalex.org/W1985716741","https://openalex.org/W2059121588","https://openalex.org/W2062617274","https://openalex.org/W2003320371","https://openalex.org/W2026147104","https://openalex.org/W2084250730","https://openalex.org/W2150332288"],"abstract_inverted_index":{"Generalized":[0],"anxiety":[1,149],"disorder":[2],"(GAD)":[3],"is":[4,13,63,77,158,166],"a":[5,30,35,64,87],"common,":[6],"typically":[7],"persistent,":[8],"and":[9,25,56,110,142,147,182,198],"disabling":[10],"condition":[11],"that":[12,189],"often":[14],"not":[15],"recognised,":[16],"or":[17,47,119],"treated":[18],"in":[19,37,86,98,126,160,184,202],"an":[20,136,174],"evidence-based":[21],"manner.":[22],"Current":[23],"pharmacological":[24],"psychological":[26,46,146],"treatment":[27,128],"approaches":[28],"have":[29,192],"number":[31],"of":[32,39,50,67,94,104,116,129,135,139,143,155,163],"drawbacks,":[33],"including":[34],"delay":[36],"onset":[38,138],"clinical":[40,140],"effect,":[41,141],"varying":[42],"relative":[43],"efficacy":[44,125,144],"against":[45],"somatic":[48,148],"symptoms":[49,58],"anxiety,":[51],"potentially":[52],"troublesome":[53],"adverse":[54,179],"effects,":[55],"discontinuation":[57],"on":[59],"stopping":[60],"treatment.":[61,204],"Pregabalin":[62],"structural":[65],"analog":[66],"the":[68,91,161],"inhibitory":[69],"neurotransmitter":[70],"gamma":[71],"amino":[72],"butyric":[73],"acid":[74],"(GABA)":[75],"but":[76],"thought":[78],"to":[79,90],"exert":[80],"its":[81],"anxiolytic":[82],"effects":[83],"through":[84],"binding":[85],"state-dependent":[88],"manner":[89],"alpha-2-delta":[92],"sub-unit":[93],"voltage-gated":[95],"calcium":[96],"channels":[97],"\"over-excited\"":[99],"pre-synaptic":[100],"neurones,":[101],"reducing":[102],"release":[103],"excitatory":[105],"neurotransmitters":[106],"such":[107],"as":[108],"glutamate":[109],"substance":[111],"P.":[112],"At":[113],"fixed":[114],"doses":[115],"200":[117],"mg/day":[118,157],"greater,":[120],"it":[121],"has":[122],"consistent":[123],"proven":[124],"acute":[127],"DSM-IV-defined":[130],"GAD,":[131],"with":[132,173],"some":[133,193],"evidence":[134],"early":[137],"across":[145],"symptom":[150],"clusters.":[151],"A":[152],"pregabalin":[153,190],"dosage":[154],"450":[156],"efficacious":[159],"prevention":[162],"relapse.":[164],"There":[165],"at":[167,200],"present":[168],"no":[169],"published":[170],"direct":[171],"comparison":[172],"SSRI.":[175],"The":[176],"current":[177],"known":[178],"effect":[180],"profile":[181],"studies":[183],"healthy":[185],"volunteers":[186],"together":[187],"suggest":[188],"may":[191],"tolerability":[194],"advantages":[195],"over":[196],"benzodiazepines":[197],"venlafaxine,":[199],"least":[201],"short-term":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}