{"id":"https://openalex.org/W1977257516","doi":"https://doi.org/10.1074/jbc.m306939200","title":"14-3-3\u03b6 C-terminal Stretch Changes Its Conformation upon Ligand Binding and Phosphorylation at Thr232","display_name":"14-3-3\u03b6 C-terminal Stretch Changes Its Conformation upon Ligand Binding and Phosphorylation at Thr232","publication_year":2004,"publication_date":"2004-01-30","ids":{"openalex":"https://openalex.org/W1977257516","doi":"https://doi.org/10.1074/jbc.m306939200","mag":"1977257516","pmid":"https://pubmed.ncbi.nlm.nih.gov/14613942"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m306939200","doi":"https://doi.org/10.1074/jbc.m306939200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306939200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m306939200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060677753","display_name":"Veronika Ob\u0161ilov\u00e1","orcid":"https://orcid.org/0000-0003-4887-0323","observed_orcids":["https://orcid.org/0000-0003-4887-0323"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Veronika Obsilova","raw_affiliation_strings":["Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 128 43 Prague, Czech Republic","Institutes of Physiology, 142 20 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 128 43 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Institutes of Physiology, 142 20 Prague, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087375961","display_name":"Petr He\u0159man","orcid":"https://orcid.org/0000-0001-6918-2576","observed_orcids":["https://orcid.org/0000-0001-6918-2576"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Herman","raw_affiliation_strings":["Institute of Physics, Faculty of Mathematics and Physics, Charles University, 128 43 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics, Faculty of Mathematics and Physics, Charles University, 128 43 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088725325","display_name":"Jaroslav Ve\u010de\u0159","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jaroslav Vecer","raw_affiliation_strings":["Institute of Physics, Faculty of Mathematics and Physics, Charles University, 128 43 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics, Faculty of Mathematics and Physics, Charles University, 128 43 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041004576","display_name":"Miroslav \u0160ulc","orcid":"https://orcid.org/0000-0002-2659-0489","observed_orcids":["https://orcid.org/0000-0002-2659-0489"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Miroslav Sulc","raw_affiliation_strings":["Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354880","display_name":"Jan Teisinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Teisinger","raw_affiliation_strings":["Institutes of Physiology, 142 20 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes of Physiology, 142 20 Prague, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007535795","display_name":"Tom\u00e1\u0161 Ob\u0161il","orcid":"https://orcid.org/0000-0003-4602-1272","observed_orcids":["https://orcid.org/0000-0003-4602-1272"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Tomas Obsil","raw_affiliation_strings":["Department of Physical and Macromolecular Chemistry, Faculty of Science, 128 43 Prague, Czech Republic","Institutes of Physiology, 142 20 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical and Macromolecular Chemistry, Faculty of Science, 128 43 Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Institutes of Physiology, 142 20 Prague, Czech Republic","institution_ids":["https://openalex.org/I4210166371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007535795"],"corresponding_institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210166371"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6592,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.81487496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"279","issue":"6","first_page":"4531","last_page":"4540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/14-3-3","display_name":"14-3-3\u03b6","score":0.968999981880188},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8579999804496765},{"id":"https://openalex.org/keywords/casein-kinase-1","display_name":"casein kinase 1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phosphopeptide-binding","display_name":"phosphopeptide binding","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intrinsic-fluorescence","display_name":"intrinsic fluorescence","score":0.5389999747276306},{"id":"https://openalex.org/keywords/serotonin-n-acetyltransferase","display_name":"serotonin N-acetyltransferase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-protein-interaction-regulation","display_name":"protein-protein interaction regulation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/protein-flexibility","display_name":"protein flexibility","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2779933727","wikidata":"https://www.wikidata.org/wiki/Q7187535","display_name":"Phosphopeptide","level":3,"score":0.9480066299438477},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7567582130432129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6242892742156982},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5642842054367065},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4627388119697571},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.46051469445228577},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4395582377910614},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.435889333486557},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.42812296748161316},{"id":"https://openalex.org/C111357860","wikidata":"https://www.wikidata.org/wiki/Q903807","display_name":"Fluorescence anisotropy","level":3,"score":0.4132285714149475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3574722409248352},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.20325171947479248},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.16626319289207458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16196873784065247},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m306939200","doi":"https://doi.org/10.1074/jbc.m306939200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306939200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:14613942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14613942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m306939200","doi":"https://doi.org/10.1074/jbc.m306939200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m306939200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W989324479","https://openalex.org/W1490071206","https://openalex.org/W1512092650","https://openalex.org/W1513601545","https://openalex.org/W1524608481","https://openalex.org/W1969184859","https://openalex.org/W1972810488","https://openalex.org/W1979331393","https://openalex.org/W1980217369","https://openalex.org/W1980302753","https://openalex.org/W1983741980","https://openalex.org/W1987835768","https://openalex.org/W1989547445","https://openalex.org/W1990016929","https://openalex.org/W1990425248","https://openalex.org/W1990783034","https://openalex.org/W1997877772","https://openalex.org/W1998773453","https://openalex.org/W2013452582","https://openalex.org/W2021741533","https://openalex.org/W2022364867","https://openalex.org/W2024923170","https://openalex.org/W2027186143","https://openalex.org/W2035266068","https://openalex.org/W2037209683","https://openalex.org/W2049475242","https://openalex.org/W2052498269","https://openalex.org/W2058742976","https://openalex.org/W2067174909","https://openalex.org/W2071075259","https://openalex.org/W2072286780","https://openalex.org/W2074534173","https://openalex.org/W2077895194","https://openalex.org/W2078594804","https://openalex.org/W2082020876","https://openalex.org/W2083240338","https://openalex.org/W2086513901","https://openalex.org/W2086992674","https://openalex.org/W2087826959","https://openalex.org/W2088751510","https://openalex.org/W2093037417","https://openalex.org/W2100322860","https://openalex.org/W2122772601","https://openalex.org/W2128572087","https://openalex.org/W2141199733","https://openalex.org/W2152204239","https://openalex.org/W2155597232","https://openalex.org/W2160043058","https://openalex.org/W2165779834","https://openalex.org/W2471648771","https://openalex.org/W4213362025"],"related_works":["https://openalex.org/W2048059179","https://openalex.org/W7030163879","https://openalex.org/W2160076451","https://openalex.org/W2736479684","https://openalex.org/W2024305758","https://openalex.org/W2605341384","https://openalex.org/W1963754786","https://openalex.org/W2049863833","https://openalex.org/W2987268898","https://openalex.org/W2016269899"],"abstract_inverted_index":{"14-3-3":[0,12,43,211,231],"proteins":[1,5,13,17],"are":[2],"abundant":[3],"binding":[4,32,76,123,155,232],"involved":[6,141],"in":[7,18,49,53,142,151,227],"many":[8],"biologically":[9],"important":[10,225],"processes.":[11],"bind":[14],"to":[15,65,115],"other":[16],"a":[19,46,51,81,194],"phosphorylation-dependent":[20],"manner":[21],"and":[22,60,77,127,156,202],"function":[23],"as":[24,100],"scaffold":[25],"molecules":[26],"modulating":[27],"the":[28,39,54,70,106,125,129,179,207,210,217,220,228],"activity":[29],"of":[30,42,56,69,105,131,146,153,158,161,167,178,198,209,219,230],"their":[31],"partners.":[33],"In":[34,183],"this":[35,89,137],"work,":[36],"we":[37],"studied":[38],"conformational":[40],"changes":[41,68,124,177,203],"C-terminal":[44,71,107,133,180,200,221],"stretch,":[45,134],"region":[47,138],"implicated":[48],"playing":[50],"role":[52,226],"regulation":[55,229],"14-3-3.":[57],"Time-resolved":[58,117,165],"fluorescence":[59,103,118,166],"molecular":[61,185],"dynamics":[62],"were":[63,113],"used":[64],"investigate":[66],"structural":[67],"stretch":[72,108,181,201,222],"induced":[73],"by":[74],"phosphopeptide":[75,122,154],"phosphorylation":[78,85,172,190],"at":[79,95,148,173,191],"Thr232,":[80],"casein":[82],"kinase":[83],"I":[84],"site":[86],"located":[87],"within":[88],"region.":[90],"A":[91],"tryptophan":[92,111],"residue":[93],"placed":[94],"position":[96],"242":[97],"was":[98],"exploited":[99],"an":[101,224],"intrinsic":[102],"probe":[104],"dynamics.":[109],"Other":[110],"residues":[112],"mutated":[114],"phenylalanine.":[116],"measurements":[119],"revealed":[120,170],"that":[121,136,171,189,216],"conformation":[126,197,218],"increases":[128],"flexibility":[130],"14-3-3zeta":[132,147,199],"demonstrating":[135],"is":[139],"directly":[140],"ligand":[143],"binding.":[144],"Phosphorylation":[145],"Thr232":[149,174,192],"resulted":[150],"inhibition":[152],"suppression":[157],"14-3-3-mediated":[159],"enhancement":[160],"serotonin":[162],"N-acetyltransferase":[163],"activity.":[164],"Trp242":[168],"also":[169],"induces":[175,193],"significant":[176],"conformation.":[182],"addition,":[184],"dynamic":[186],"simulations":[187],"suggest":[188],"more":[195],"extended":[196],"its":[204],"interaction":[205],"with":[206],"rest":[208],"molecule.":[212],"These":[213],"results":[214],"indicate":[215],"plays":[223],"properties.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
