{"id":"https://openalex.org/W1977197925","doi":"https://doi.org/10.1093/nar/8.12.2605","title":"Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA","display_name":"Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W1977197925","doi":"https://doi.org/10.1093/nar/8.12.2605","mag":"1977197925","pmid":"https://pubmed.ncbi.nlm.nih.gov/6159578","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/324109"},"language":"en","primary_location":{"id":"doi:10.1093/nar/8.12.2605","doi":"https://doi.org/10.1093/nar/8.12.2605","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/8.12.2605","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/324109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073917989","display_name":"Palmiro Cantatore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Palmiro Cantatore","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061536209","display_name":"Giuseppe M. Attardi","orcid":"https://orcid.org/0000-0003-3875-6404","observed_orcids":["https://orcid.org/0000-0003-3875-6404"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Attardi","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":4.4251,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.95612891,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"12","first_page":"2605","last_page":"2626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nascent-rna","display_name":"nascent RNA","score":0.7300000190734863},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7480000257492065},{"id":"https://openalex.org/keywords/replication-origins","display_name":"origin of replication","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/rna-dna-hybrids","display_name":"RNA-DNA hybrids","score":0.6110000014305115},{"id":"https://openalex.org/keywords/mitochondrial-transcription","display_name":"mitochondrial transcription","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8724241256713867},{"id":"https://openalex.org/C171288974","wikidata":"https://www.wikidata.org/wiki/Q5695283","display_name":"Heavy strand","level":5,"score":0.815707802772522},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7073571085929871},{"id":"https://openalex.org/C119489563","wikidata":"https://www.wikidata.org/wiki/Q5140301","display_name":"Coding strand","level":4,"score":0.6405425071716309},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.63896244764328},{"id":"https://openalex.org/C199728103","wikidata":"https://www.wikidata.org/wiki/Q959053","display_name":"Transcription bubble","level":5,"score":0.5223922729492188},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5058721899986267},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5053439736366272},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.502361536026001},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.48951900005340576},{"id":"https://openalex.org/C170673058","wikidata":"https://www.wikidata.org/wiki/Q780686","display_name":"Restriction map","level":4,"score":0.4375542998313904},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.421281635761261},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4149166941642761},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35604336857795715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2841995060443878},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.15801361203193665},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.1514490246772766},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.14786237478256226},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.13503345847129822},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019003","descriptor_name":"Deoxyribonuclease HpaII","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/8.12.2605","doi":"https://doi.org/10.1093/nar/8.12.2605","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/8.12.2605","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1293058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/324109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:324109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/324109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:6159578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6159578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:2023","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:CANnar80","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1293058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/324109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1511458875","https://openalex.org/W1518059580","https://openalex.org/W1526101099","https://openalex.org/W1573876426","https://openalex.org/W1973382928","https://openalex.org/W1983612731","https://openalex.org/W1984395096","https://openalex.org/W1995908964","https://openalex.org/W1997429622","https://openalex.org/W2007576361","https://openalex.org/W2020708197","https://openalex.org/W2029987769","https://openalex.org/W2041705590","https://openalex.org/W2044367379","https://openalex.org/W2053040757","https://openalex.org/W2054073262","https://openalex.org/W2059911651","https://openalex.org/W2067393357","https://openalex.org/W2072573620","https://openalex.org/W2120396987","https://openalex.org/W2152193561","https://openalex.org/W2160169856"],"related_works":["https://openalex.org/W1998974825","https://openalex.org/W2014257871","https://openalex.org/W2053040757","https://openalex.org/W1980360743","https://openalex.org/W1992051336","https://openalex.org/W2010831956","https://openalex.org/W2020708197","https://openalex.org/W1995908964","https://openalex.org/W1518059580","https://openalex.org/W7102408135"],"abstract_inverted_index":{"The":[0,32],"sequences":[1,36],"complementary":[2],"to":[3,45,71,99,112,132],"the":[4,20,28,47,53,60,65,72,76,79,84,95,100,104,108,116,120,126,129,133,136,147,152],"nascent":[5],"RNA":[6],"molecules":[7],"isolated":[8],"from":[9],"transcription":[10,163],"complexes":[11],"of":[12,25,34,49,57,75,81,86,119,128,138,149,154],"HeLa":[13],"cell":[14],"mtDNA":[15,26,150],"have":[16],"been":[17],"mapped":[18],"on":[19],"H":[21,109,139,169],"and":[22,90,122,164],"L":[23,66,87,161],"strands":[24],"by":[27],"S1":[29],"protection":[30],"technique.":[31],"distribution":[33],"these":[35,50],"among":[37],"different":[38],"Hpa":[39,54],"II":[40,55],"restriction":[41],"fragments":[42,51],"was":[43],"found":[44],"reflect":[46],"position":[48],"in":[52,83,94,115,123,125,135],"map":[56,130],"mtDNA.":[58],"Thus,":[59],"S1-resistant":[61],"hybrids":[62],"formed":[63],"with":[64],"strand":[67,88,110,140,162,170],"corresponded":[68],"almost":[69],"exclusively":[70],"right":[73],"half":[74,118],"genome":[77],"past":[78],"origin":[80,134,153],"replication":[82,155],"direction":[85,137],"transcription,":[89],"were":[91],"especially":[92],"concentrated":[93],"region":[96,148],"immediately":[97],"adjacent":[98,131],"origin.":[101],"By":[102],"contrast,":[103],"hybrid":[105],"duplexes":[106],"involving":[107],"appeared":[111],"be":[113],"localized":[114],"left":[117],"genome,":[121],"particular":[124],"quadrant":[127],"transcription.":[141,171],"These":[142],"results":[143],"strongly":[144],"suggest":[145],"that":[146],"around":[151],"contains":[156],"an":[157,165],"initiation":[158,166],"site":[159,167],"for":[160,168]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}