{"id":"https://openalex.org/W1977167243","doi":"https://doi.org/10.1177/000348947408300210","title":"Ethacrynic Acid, Furosemide, and Vestibular Caloric Responses","display_name":"Ethacrynic Acid, Furosemide, and Vestibular Caloric Responses","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W1977167243","doi":"https://doi.org/10.1177/000348947408300210","mag":"1977167243","pmid":"https://pubmed.ncbi.nlm.nih.gov/4593810"},"language":"en","primary_location":{"id":"doi:10.1177/000348947408300210","doi":"https://doi.org/10.1177/000348947408300210","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000348947408300210","pdf_url":null,"source":{"id":"https://openalex.org/S174332447","display_name":"Annals of Otology Rhinology & Laryngology","issn_l":"0003-4894","issn":["0003-4894","1943-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Otology, Rhinology & Laryngology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Richard M. Levinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard M. Levinson","raw_affiliation_strings":["Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minneapolis, Minnesota","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082264582","display_name":"Mary Jayne Capps","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Jayne Capps","raw_affiliation_strings":["Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minneapolis, Minnesota","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079570579","display_name":"Robert H. Mathog","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert H. Mathog","raw_affiliation_strings":["Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minneapolis, Minnesota","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.2841,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.85726569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"83","issue":"2","first_page":"223","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethacrynic-acid","display_name":"ethacrynic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":1.0},{"id":"https://openalex.org/keywords/vestibular-nystagmus","display_name":"vestibular nystagmus","score":0.9110000133514404},{"id":"https://openalex.org/keywords/loop-diuretics","display_name":"loop diuretics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/slow-phase-velocity","display_name":"slow phase velocity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.870351254940033},{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.8361339569091797},{"id":"https://openalex.org/C2779736392","wikidata":"https://www.wikidata.org/wiki/Q220989","display_name":"Nystagmus","level":2,"score":0.6809366345405579},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6518789529800415},{"id":"https://openalex.org/C190362976","wikidata":"https://www.wikidata.org/wiki/Q845261","display_name":"Caloric theory","level":2,"score":0.5734803676605225},{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.4363316297531128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43160688877105713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39596301317214966},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3792598247528076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36330270767211914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3514441251754761},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.25314438343048096},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004585","descriptor_name":"Electrooculography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004976","descriptor_name":"Ethacrynic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004976","descriptor_name":"Ethacrynic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005133","descriptor_name":"Eye Movements","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007507","descriptor_name":"Therapeutic Irrigation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014722","descriptor_name":"Vestibule, Labyrinth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014724","descriptor_name":"Vestibular Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/000348947408300210","doi":"https://doi.org/10.1177/000348947408300210","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000348947408300210","pdf_url":null,"source":{"id":"https://openalex.org/S174332447","display_name":"Annals of Otology Rhinology & Laryngology","issn_l":"0003-4894","issn":["0003-4894","1943-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Otology, Rhinology & Laryngology","raw_type":"journal-article"},{"id":"pmid:4593810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4593810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of otology, rhinology, and laryngology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W143134428","https://openalex.org/W1972395909","https://openalex.org/W1989314580","https://openalex.org/W1992125372","https://openalex.org/W1999285254","https://openalex.org/W2003079326","https://openalex.org/W2007350339","https://openalex.org/W2019690833","https://openalex.org/W2025191506","https://openalex.org/W2027146452","https://openalex.org/W2031579832","https://openalex.org/W2037020588","https://openalex.org/W2068335453","https://openalex.org/W2091402317","https://openalex.org/W2117655757","https://openalex.org/W2119577485","https://openalex.org/W2131135561","https://openalex.org/W2164682022","https://openalex.org/W2408599835"],"related_works":["https://openalex.org/W2417824058","https://openalex.org/W2133721682","https://openalex.org/W2315468452","https://openalex.org/W2003079326","https://openalex.org/W2168810805","https://openalex.org/W2408225463","https://openalex.org/W143134428","https://openalex.org/W2287839617","https://openalex.org/W2312297402","https://openalex.org/W4416949076"],"abstract_inverted_index":{"Ethacrynic":[0],"acid":[1,32],"and":[2,89,105,147],"furosemide,":[3],"saluretic":[4],"diuretics":[5],"of":[6,30,45,53,76,82,87,126,137,145,150],"high":[7],"potency,":[8],"have":[9],"been":[10],"shown":[11],"to":[12,15,58],"be":[13],"toxic":[14],"the":[16,20,27,35,54,77,118,151],"auditory":[17],"system.":[18,37],"In":[19],"present":[21],"study,":[22],"it":[23],"was":[24,69,95],"found":[25],"that":[26],"depressant":[28],"effect":[29,94],"ethacrynic":[31,46,152],"extends":[33],"into":[34],"vestibular":[36,55,119,154],"Cats,":[38],"given":[39],"a":[40,49,59],"20":[41,111,129],"mg/kg":[42],"intravenous":[43],"bolus":[44],"acid,":[47],"exhibited":[48],"50%":[50],"greater":[51],"reduction":[52],"nystagmus":[56,79],"response":[57,80],"caloric":[60],"irrigation":[61],"than":[62],"control":[63,138],"animals":[64,139],"receiving":[65,140],"normal":[66,109,141],"saline.":[67,142],"This":[68,93],"true":[70],"for":[71],"all":[72],"three":[73],"major":[74],"parameters":[75],"recorded":[78],"(degrees":[81],"slow":[83,90],"phase":[84,91],"displacement,":[85],"frequency":[86],"beats":[88],"velocity).":[92],"very":[96],"rapid":[97],"in":[98],"onset":[99],"(present":[100],"at":[101],"30":[102],"seconds":[103],"postinjection),":[104],"quite":[106],"transient":[107],"(approaching":[108],"by":[110],"minutes":[112],"postinjection).":[113],"Furosemide":[114],"did":[115],"not":[116,132],"produce":[117],"depression.":[120],"Nystagmus":[121],"responses":[122],"observed":[123],"after":[124],"injection":[125],"furosemide":[127],"(at":[128],"mg/kg)":[130],"were":[131],"significantly":[133],"different":[134],"from":[135],"those":[136],"Possible":[143],"mechanisms":[144],"action":[146],"therapeutic":[148],"implications":[149],"acid-induced":[153],"depression":[155],"are":[156],"discussed.":[157]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}