{"id":"https://openalex.org/W1977042007","doi":"https://doi.org/10.1158/1538-7445.am2012-5562","title":"Abstract 5562: Utility of circulating biomarkers as outcome predictors in metastatic colorectal cancer and recurrent glioblastoma multiforme patients treated with bevacizumab/sorafenib","display_name":"Abstract 5562: Utility of circulating biomarkers as outcome predictors in metastatic colorectal cancer and recurrent glioblastoma multiforme patients treated with bevacizumab/sorafenib","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1977042007","doi":"https://doi.org/10.1158/1538-7445.am2012-5562","mag":"1977042007"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-5562","doi":"https://doi.org/10.1158/1538-7445.am2012-5562","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-5562","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031116230","display_name":"Jacqueline M. Lafky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline M. Lafky","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029973","display_name":"S. Keith Anderson","orcid":"https://orcid.org/0000-0003-1542-9726","observed_orcids":["https://orcid.org/0000-0003-1542-9726"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Keith Anderson","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082299880","display_name":"Bruce W. Morlan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce W. Morlan","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022512837","display_name":"Garth D. Nelson","orcid":"https://orcid.org/0009-0002-0709-1155","observed_orcids":["https://orcid.org/0009-0002-0709-1155"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garth D. Nelson","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022032777","display_name":"Xiomara W. Carrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiomara W. Carrero","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026574827","display_name":"Shaji Kunnathu Kumar","orcid":"https://orcid.org/0000-0001-5392-9284","observed_orcids":["https://orcid.org/0000-0001-5392-9284"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaji Kumar","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John T. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148477","display_name":"Medtronic (Germany)","ror":"https://ror.org/05ttsqg93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210091810","https://openalex.org/I4210148477"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"John T. Reynolds","raw_affiliation_strings":["2Medcenter One Health System, Bismarck, ND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medcenter One Health System, Bismarck, ND","institution_ids":["https://openalex.org/I4210148477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037503098","display_name":"Philip J. Stella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174354714","display_name":"Trinity Health Michigan","ror":"https://ror.org/01w8eym62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304269903","https://openalex.org/I174354714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Stella","raw_affiliation_strings":["3St. Joseph Mercy Health System, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3St. Joseph Mercy Health System, Ann Arbor, MI","institution_ids":["https://openalex.org/I174354714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064449830","display_name":"Shaker R. Dakhil","orcid":"https://orcid.org/0000-0002-6261-5882","observed_orcids":["https://orcid.org/0000-0002-6261-5882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaker R. Dakhil","raw_affiliation_strings":["4Wichita Community Clinical Oncology Program, Wichita, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Wichita Community Clinical Oncology Program, Wichita, KS","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063589088","display_name":"William S. Loui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Loui","raw_affiliation_strings":["5University of Hawaii Cancer Center, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Hawaii Cancer Center, Honolulu, HI","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019214686","display_name":"Steven R. Alberts","orcid":"https://orcid.org/0000-0002-5835-4122","observed_orcids":["https://orcid.org/0000-0002-5835-4122"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Alberts","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012465182","display_name":"Patrick J. Flynn","orcid":"https://orcid.org/0000-0001-6516-8021","observed_orcids":["https://orcid.org/0000-0001-6516-8021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick J. Flynn","raw_affiliation_strings":["6Metro MN CCOP, St. Louis Park, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Metro MN CCOP, St. Louis Park, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019894304","display_name":"Howard M. Gross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard M. Gross","raw_affiliation_strings":["7Hematology & Oncology of Dayton, Inc., Dayton, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Hematology & Oncology of Dayton, Inc., Dayton, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657472","display_name":"Kurt A. Jaeckle","orcid":"https://orcid.org/0000-0002-7827-463X","observed_orcids":["https://orcid.org/0000-0002-7827-463X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt A. Jaeckle","raw_affiliation_strings":["8Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104319","display_name":"Jan C. Buckner","orcid":"https://orcid.org/0000-0002-8688-266X","observed_orcids":["https://orcid.org/0000-0002-8688-266X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan C. Buckner","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017494786","display_name":"Evanthia Galanis","orcid":"https://orcid.org/0000-0001-8014-786X","observed_orcids":["https://orcid.org/0000-0001-8014-786X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evanthia Galanis","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002036484","display_name":"Axel AG Grothey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Axel Grothey","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN","#N#1Mayo Clinic, Rochester, MN#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"#N#1Mayo Clinic, Rochester, MN#N#","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"5562","last_page":"5562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.4350999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5540000200271606},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":1.0},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sdf-1alpha","display_name":"SDF-1\u03b1","score":0.824999988079071},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7590000033378601},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7570000290870667},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.503000020980835},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.5720000267028809},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/skits","display_name":"skits","score":0.8109999895095825},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.9109892845153809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8725655674934387},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.784084677696228},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7373074293136597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.701571524143219},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6727307438850403},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5624802112579346},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5212215185165405},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4862769842147827},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46118929982185364},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4390449523925781},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.41548818349838257},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.37743133306503296},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3325764536857605},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24091827869415283},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23670831322669983},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.16299673914909363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-5562","doi":"https://doi.org/10.1158/1538-7445.am2012-5562","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-5562","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3007100859","https://openalex.org/W2121231785","https://openalex.org/W4286298414","https://openalex.org/W2588394191","https://openalex.org/W2335296528","https://openalex.org/W2596887384","https://openalex.org/W2803670008","https://openalex.org/W2767845893","https://openalex.org/W3011137804","https://openalex.org/W2516535717"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Surrogate":[2],"biomarkers":[3,18],"are":[4],"lacking":[5],"for":[6,61,146,170,236,249,286,340,355,389],"predicting":[7,356],"or":[8,160,217,246,315],"monitoring":[9],"response":[10],"to":[11,104,134,150,187,209],"anti-angiogenesis":[12],"therapies.":[13],"We":[14,240],"investigated":[15],"whether":[16],"circulating":[17],"(CBMs)":[19],"of":[20,38,165,251,257,290,300,303,320,353,380,385],"angiogenesis":[21],"(i.e.,":[22],"bFGF,":[23],"SDF-1\u03b1,":[24],"HGF,":[25],"sKIT,":[26],"Ang-2,":[27],"and":[28,43,84,114,131,198,268,281,368],"PlGF)":[29],"correlated":[30,276,310],"with":[31,51,154,277,311,348,359],"treatment":[32,105,342,361],"efficacy":[33,343],"in":[34,67,214,244,344,363],"a":[35,140,237,298,337],"pooled":[36,230,262],"analysis":[37],"metastatic":[39],"colorectal":[40],"cancer":[41],"(mCRC)":[42],"recurrent":[44],"glioblastoma":[45],"multiforme":[46],"(rGBM)":[47],"patients":[48,232],"(pts)":[49],"treated":[50,347],"bevacizumab/sorafenib":[52],"(BEV/SOR).":[53],"Experimental":[54],"procedures:":[55],"Peripheral":[56],"blood":[57,168,323],"samples":[58],"were":[59,124,274,308],"obtained":[60],"CBM":[62,122,306,339],"analyses":[63],"from":[64,184,191,196,202,233],"pts":[65,223,346],"enrolled":[66],"the":[68,116,152,166,171,215,222,231,252,255,294,304,321,381,386],"North":[69],"Central":[70],"Cancer":[71,390,401],"Treatment":[72],"Group":[73],"(NCCTG)":[74],"phase":[75],"II":[76],"studies":[77,235],"N054C":[78],"(mCRC,":[79],"n=75,":[80],"Grothey,":[81],"ASCO":[82,89],"2010)":[83],"N0776":[85],"(rGBM,":[86],"n=54,":[87],"Galanis,":[88],"2010).":[90],"Blood":[91],"collection":[92],"time":[93],"points":[94],"were:":[95],"baseline":[96],"(BL),":[97],"cycle":[98,188],"1":[99],"day":[100],"3":[101],"(C1D3),":[102],"prior":[103,186,203],"cycles":[106],"2,":[107],"3,":[108],"5,":[109],"7,":[110],"9,":[111],"11,":[112],"13,":[113],"after":[115],"pt":[117,357],"went":[118],"off":[119],"study.":[120],"Plasma":[121],"levels":[123,248,273],"determined":[125],"by":[126],"commercially-available":[127],"ELISAs":[128],"(R&D":[129],"Systems)":[130],"performed":[132],"according":[133],"manufacturer's":[135],"instructions.":[136],"For":[137],"each":[138],"CBM,":[139],"linear":[141],"regression":[142],"model":[143],"that":[144,333],"adjusted":[145],"study":[147,329],"was":[148],"used":[149],"evaluate":[151],"correlation":[153],"either":[155,312],"progression-free":[156],"survival":[157,219],"(PFS)":[158],"success/failure":[159,314],"progression":[161,316,358],"within":[162,317],"14":[163,318],"days":[164,319],"last":[167,193,199,322],"draw":[169,194,200,324],"following":[172],"measures:":[173],"absolute":[174,245,267],"BL":[175,178,271],"levels,":[176],"log2":[177,247,270],"levels;":[179],"C1D3":[180],"log2-fold":[181],"change":[182],"(FC)":[183],"BL,":[185,192,197],"2":[189],"log2-FC":[190,195,201],"draw.":[204],"Results":[205],"summary:":[206],"There":[207],"appears":[208,370],"be":[210,336],"no":[211,242],"significant":[212],"difference":[213,243],"PFS":[216,278,313],"overall":[218],"(OS)":[220],"between":[221],"on":[224],"these":[225,261,345],"two":[226],"studies;":[227],"therefore,":[228],"we":[229,264],"both":[234],"combined":[238],"analyses.":[239],"found":[241,265],"any":[250],"CBMs":[253],"during":[254],"course":[256],"BEV/SOR":[258],"treatment.":[259],"In":[260],"analyses,":[263],"increased":[266,269],"SDF-1\u03b1":[272,334,354],"significantly":[275,309],"success":[279],"(p=0.023":[280],"p=0.02,":[282],"respectively).":[283],"After":[284],"correcting":[285],"multiple":[287],"comparisons":[288],"(method":[289],"Benjamini":[291],"&":[292],"Hochberg)":[293],"p-values":[295],"<0.05":[296],"had":[297],"false-discovery-rate":[299],"41.4%.":[301],"None":[302],"other":[305],"measures":[307],"(all":[325],"p>0.10).":[326],"Conclusions:":[327],"This":[328],"provides":[330],"preliminary":[331],"evidence":[332],"may":[335],"useful":[338],"determining":[341],"BEV/SOR.":[349],"Further":[350],"prospective":[351],"validation":[352],"this":[360],"combination":[362],"advanced":[364],"disease":[365],"(e.g.,":[366],"mCRC":[367],"rGBM)":[369],"warranted.":[371],"Citation":[372],"Format:":[373],"{Authors}.":[374],"{Abstract":[375],"title}":[376],"[abstract].":[377],"In:":[378],"Proceedings":[379],"103rd":[382],"Annual":[383],"Meeting":[384],"American":[387],"Association":[388],"Research;":[391],"2012":[392],"Mar":[393],"31-Apr":[394],"4;":[395],"Chicago,":[396],"IL.":[397],"Philadelphia":[398],"(PA):":[399],"AACR;":[400],"Res":[402],"2012;72(8":[403],"Suppl):Abstract":[404],"nr":[405],"5562.":[406],"doi:1538-7445.AM2012-5562":[407]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
