{"id":"https://openalex.org/W1977005359","doi":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","title":"Expression pattern of antimicrobial peptides (AMPs) in acanthamoeba keratitis","display_name":"Expression pattern of antimicrobial peptides (AMPs) in acanthamoeba keratitis","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W1977005359","doi":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","mag":"1977005359"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-3768.2008.6324.x","doi":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048788636","display_name":"AM OTRI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AM OTRI","raw_affiliation_strings":["Ophthalmology, Nottingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Nottingham","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111405287","display_name":"A. Abedin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A ABEDIN","raw_affiliation_strings":["Ophthalmology, Nottingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Nottingham","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069736552","display_name":"Imran Mohammed","orcid":"https://orcid.org/0000-0002-8412-0768","observed_orcids":["https://orcid.org/0000-0002-8412-0768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I MOHAMMED","raw_affiliation_strings":["Ophthalmology, Nottingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Nottingham","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029103579","display_name":"Noorjahan Panjwani","orcid":"https://orcid.org/0000-0002-0821-9686","observed_orcids":["https://orcid.org/0000-0002-0821-9686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N PANJWANI","raw_affiliation_strings":["New England Eye Centre, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New England Eye Centre, Boston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085641393","display_name":"Andrew Hopkinson","orcid":"https://orcid.org/0000-0003-3394-6196","observed_orcids":["https://orcid.org/0000-0003-3394-6196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A HOPKINSON","raw_affiliation_strings":["Ophthalmology, Nottingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Nottingham","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108194896","display_name":"HS DUA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HS DUA","raw_affiliation_strings":["Ophthalmology, Nottingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Nottingham","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"s243","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthamoeba-keratitis","display_name":"Acanthamoeba keratitis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":1.0},{"id":"https://openalex.org/keywords/beta-defensins","display_name":"beta-defensins","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cathelicidin","display_name":"cathelicidin","score":0.953000009059906},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/acanthamoeba-castellanii","display_name":"Acanthamoeba castellanii","score":0.9269999861717224},{"id":"https://openalex.org/keywords/impression-cytology","display_name":"imprint cytology","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.8315539360046387},{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.8066157102584839},{"id":"https://openalex.org/C2778868110","wikidata":"https://www.wikidata.org/wiki/Q1152218","display_name":"Acanthamoeba","level":2,"score":0.7646651268005371},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.628876268863678},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6064938902854919},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6048133969306946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5724114179611206},{"id":"https://openalex.org/C2780576314","wikidata":"https://www.wikidata.org/wiki/Q922971","display_name":"Acanthamoeba keratitis","level":3,"score":0.5253036618232727},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45694053173065186},{"id":"https://openalex.org/C2986805488","wikidata":"https://www.wikidata.org/wiki/Q23797","display_name":"Contact lens","level":2,"score":0.4319204092025757},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43034419417381287},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37195008993148804},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.30650514364242554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2837972939014435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2027374505996704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07527419924736023},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1755-3768.2008.6324.x","doi":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2008.6324.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978830530","https://openalex.org/W1544218268","https://openalex.org/W2027252559","https://openalex.org/W1982695002","https://openalex.org/W7100112706","https://openalex.org/W2010151149","https://openalex.org/W2027739302","https://openalex.org/W3080501121","https://openalex.org/W2141673464","https://openalex.org/W4386912646"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Acanthamoeba":[2,94],"keratitis":[3],"(AK)":[4],"is":[5,11,194],"a":[6,195,239],"sight\u2010threatening":[7],"ocular":[8,231],"infection,":[9],"which":[10],"more":[12],"likely":[13],"in":[14,34,124,162,177,202,216],"contact":[15,240],"lens":[16,241],"wearer.":[17],"Antimicrobial":[18],"peptides(AMPs)are":[19],"cationic":[20],"polypeptides":[21],"with":[22,91],"wide\u2010spectrum":[23],"activity":[24],"against":[25],"pathogens.":[26],"We":[27],"studied(1)the":[28],"profile":[29],"of":[30,77,93,120,169,207,220,225,235],"AMP":[31,47,199,226,237],"mRNA":[32,167],"expression":[33,49,76,119,168,186,201,205],"ex\u2010vivo":[35,51],"impression":[36],"cytology":[37],"(IC)":[38],"specimen":[39],"from":[40],"normals":[41],"and":[42,52,67,99,134,136,146,154],"5":[43],"AK":[44,125,163,211,249],"patients":[45],"&(2)compared":[46],"gene":[48,71,200],"between":[50],"in\u2010vitro":[53],"cell":[54,86],"culture":[55],"samples.":[56],"Methods":[57],"a)":[58],"IC":[59],"samples":[60],"were":[61,112,139,149,160],"collected":[62],"for":[63,96,108,114],"Total":[64],"RNA":[65],"extraction":[66],"cDNA":[68],"synthesis.":[69],"Quantitative":[70],"expression(qPCR)was":[72],"employed":[73],"to":[74,130,144,151,189,246],"evaluate":[75],"Defensins,Cathelicidin,&":[78],"Liver\u2010expressed":[79],"AMPs":[80,121,209],"(LEAPs).b)":[81],"Immortalised":[82],"human":[83],"corneal":[84],"epithelial":[85],"line":[87],"(HuCL)":[88],"was":[89,122,174],"incubated":[90],"trophozoites":[92],"castellanii":[95],"24":[97],"hours":[98],"the":[100,184,218,230,236,248],"supernatant":[101],"analysed":[102],"by":[103],"BD":[104],"cytometric":[105],"bead":[106],"array":[107],"pro\u2010inflammatory":[109],"cytokines.The":[110],"cells":[111],"processed":[113],"qPCR":[115],"analyses.":[116],"Results":[117],"Variable":[118],"observed":[123],"patients.Eight":[126],"AMPs,Human":[127],"Beta":[128],"defensins(HBD)1":[129],"3,Cathelicidin":[131],"(LL37,LEAP":[132],"1":[133,143,157,171],"2":[135,159,173],"DEF":[137,147],"109":[138,148],"detected.Of":[140],"these":[141,208],"HBD":[142],"3":[145],"shown":[150],"be":[152],"reduced":[153],"whereas":[155],"LEAP":[156,170],"&":[158,172],"induced":[161],"specimen.":[164],"Similarly,":[165],"increased":[166],"also":[175],"demonstrated":[176],"Acanthamoebae":[178],"treated":[179],"HuCL":[180],"cultures.Whereas,":[181],"HBDs":[182],"showed":[183],"baseline":[185],"when":[187],"compare":[188],"untreated":[190],"HuCLs.":[191],"Conclusion":[192],"This":[193],"first":[196],"study":[197],"demonstrating":[198],"AK.":[203],"Differential":[204],"pattern":[206],"during":[210],"may":[212,244],"have":[213],"important":[214],"implications":[215],"understanding":[217],"pathogenesis":[219],"this":[221],"blinding":[222],"infection.":[223],"Modulation":[224],"defense":[227],"barrier":[228],"at":[229],"surface":[232],"or":[233],"use":[234],"as":[238],"preservative":[242],"agent":[243],"help":[245],"reduce":[247],"infections":[250]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}
