{"id":"https://openalex.org/W1976997191","doi":"https://doi.org/10.1021/bi8018114","title":"Toward Understanding the Conformational Dynamics of RNA Ligation","display_name":"Toward Understanding the Conformational Dynamics of RNA Ligation","publication_year":2009,"publication_date":"2009-01-09","ids":{"openalex":"https://openalex.org/W1976997191","doi":"https://doi.org/10.1021/bi8018114","mag":"1976997191","pmid":"https://pubmed.ncbi.nlm.nih.gov/19133737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651658"},"language":"en","primary_location":{"id":"doi:10.1021/bi8018114","doi":"https://doi.org/10.1021/bi8018114","is_oa":true,"landing_page_url":"https://doi.org/10.1021/bi8018114","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/bi8018114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003775829","display_name":"Robert V. Swift","orcid":"https://orcid.org/0000-0001-9157-5229","observed_orcids":["https://orcid.org/0000-0001-9157-5229"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert V. Swift","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084976210","display_name":"Jacob D. Durrant","orcid":"https://orcid.org/0000-0002-5808-4097","observed_orcids":["https://orcid.org/0000-0002-5808-4097"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Durrant","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081468273","display_name":"Rommie E. Amaro","orcid":"https://orcid.org/0000-0002-9275-9553","observed_orcids":["https://orcid.org/0000-0002-9275-9553"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rommie E. Amaro","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015837947","display_name":"James Andrew McCammon","orcid":"https://orcid.org/0000-0003-3065-1456","observed_orcids":["https://orcid.org/0000-0003-3065-1456"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Andrew McCammon","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093-0365, Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093-0365, and Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0365","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081468273"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.6714,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.742281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"4","first_page":"709","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-ligation","display_name":"RNA ligation","score":0.824999988079071},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.8690000176429749},{"id":"https://openalex.org/keywords/editosome","display_name":"editosome","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.7070000171661377},{"id":"https://openalex.org/keywords/conformational-dynamics","display_name":"conformational dynamics","score":0.7379999756813049},{"id":"https://openalex.org/keywords/rna-binding-specificity","display_name":"RNA binding specificity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2909068217","wikidata":"https://www.wikidata.org/wiki/Q7277177","display_name":"RNA ligase","level":4,"score":0.808451771736145},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7731735110282898},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.7304746508598328},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.6941919326782227},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.5850064754486084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5357341766357422},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.4572470188140869},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.43270236253738403},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42957985401153564},{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.4223845899105072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41042301058769226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3539562225341797},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33828288316726685},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2769433259963989},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27336937189102173},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.09250950813293457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08473667502403259},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000077278","descriptor_name":"RNA, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011130","descriptor_name":"RNA Ligase (ATP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011130","descriptor_name":"RNA Ligase (ATP)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016053","descriptor_name":"RNA, Protozoan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016053","descriptor_name":"RNA, Protozoan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017393","descriptor_name":"RNA Editing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi8018114","doi":"https://doi.org/10.1021/bi8018114","is_oa":true,"landing_page_url":"https://doi.org/10.1021/bi8018114","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2651658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Text"},{"id":"pmid:19133737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19133737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.909.306","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.909.306","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2651658%26blobtype%3Dpdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1021/bi8018114","doi":"https://doi.org/10.1021/bi8018114","is_oa":true,"landing_page_url":"https://doi.org/10.1021/bi8018114","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.5299999713897705,"display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1739821739","display_name":"The SMD-Relaxed Complex Method for Drug Design","funder_award_id":"5f32gm077729-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2796412169","display_name":null,"funder_award_id":"GM 31749","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5471768970","display_name":"Graduate Training in Cellular and Molecular Pharmacology","funder_award_id":"T32GM007752","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G712410149","display_name":null,"funder_award_id":"F32-GM077729","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7174882636","display_name":"Theory of Biomolecular Diffusion","funder_award_id":"R01GM031749","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337144","display_name":"National Supercomputing Center, Korea Institute of Science and Technology Information","ror":"https://ror.org/00cs28a13"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1920528978","https://openalex.org/W1964798261","https://openalex.org/W1969836007","https://openalex.org/W1974476489","https://openalex.org/W1976499671","https://openalex.org/W1981419683","https://openalex.org/W1990502537","https://openalex.org/W2001351981","https://openalex.org/W2001773296","https://openalex.org/W2004851259","https://openalex.org/W2006238796","https://openalex.org/W2020859487","https://openalex.org/W2025101276","https://openalex.org/W2031500190","https://openalex.org/W2038758364","https://openalex.org/W2046703384","https://openalex.org/W2055798124","https://openalex.org/W2056241412","https://openalex.org/W2066390447","https://openalex.org/W2067174909","https://openalex.org/W2082027302","https://openalex.org/W2085006387","https://openalex.org/W2103815459","https://openalex.org/W2104258472","https://openalex.org/W2104892553","https://openalex.org/W2111973517","https://openalex.org/W2132589721","https://openalex.org/W2132717858","https://openalex.org/W2142033846","https://openalex.org/W2144288821","https://openalex.org/W2145081087","https://openalex.org/W2147993766","https://openalex.org/W2150981663","https://openalex.org/W2153641622","https://openalex.org/W2154488281","https://openalex.org/W2165555600","https://openalex.org/W2171895257","https://openalex.org/W2952573657","https://openalex.org/W3086983054"],"related_works":["https://openalex.org/W2025101276","https://openalex.org/W2330621728","https://openalex.org/W2031500190","https://openalex.org/W2116481264","https://openalex.org/W2951846953","https://openalex.org/W7162102939","https://openalex.org/W2074898993","https://openalex.org/W2055747482","https://openalex.org/W1607338221","https://openalex.org/W2066390447"],"abstract_inverted_index":{"Members":[0],"of":[1,48,63,69,79,91,107,137,144],"the":[2,7,25,30,70,77,105,108,122,131,138,155],"genus":[3],"Trypanosoma,":[4],"which":[5],"include":[6],"pathogenic":[8],"species":[9],"Trypanosoma":[10,13],"brucei":[11,81],"and":[12,38,83,113,134,147,154],"cruzi,":[14],"edit":[15],"their":[16],"post-transcriptional":[17],"mitochondrial":[18],"RNA":[19,31,43,99,126,145],"via":[20],"a":[21,56,89],"multiprotein":[22],"complex":[23,94],"called":[24],"editosome.":[26],"In":[27,86],"T.":[28,80],"brucei,":[29],"is":[32,44,74,102],"nicked":[33,42],"prior":[34],"to":[35],"uridylate":[36],"insertion":[37],"deletion.":[39],"Following":[40],"editing,":[41],"religated":[45],"by":[46],"one":[47],"two":[49],"RNA-editing":[50,67],"ligases":[51,153],"(TbREL).":[52],"This":[53],"study":[54],"describes":[55],"recent":[57],"70":[58],"ns":[59],"molecular":[60],"dynamics":[61,120,133],"simulation":[62,117],"TbREL1,":[64],"an":[65],"ATP-dependent":[66],"ligase":[68],"nucleotidyltransferase":[71,157],"superfamily":[72],"that":[73],"required":[75],"for":[76,151],"survival":[78],"insect":[82],"bloodstream":[84],"forms.":[85],"this":[87],"work,":[88],"model":[90],"TbREL1":[92,112,119],"in":[93,121],"with":[95],"its":[96],"full":[97],"double-stranded":[98],"(dsRNA)":[100],"substrate":[101],"created":[103],"on":[104],"basis":[106],"homologous":[109],"relation":[110],"between":[111],"T4":[114],"Rnl2.":[115],"The":[116],"captures":[118],"state":[123],"immediately":[124],"preceding":[125],"ligation,":[127],"providing":[128],"insights":[129],"into":[130],"functional":[132],"catalytic":[135],"mechanism":[136],"kinetoplastid":[139,152],"ligation":[140],"reaction.":[141],"Important":[142],"features":[143],"binding":[146],"specificity":[148],"are":[149],"revealed":[150],"broader":[156],"superfamily.":[158]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}