{"id":"https://openalex.org/W1976995337","doi":"https://doi.org/10.1188/15.cjon.e4-e7","title":"Management of Tumor Lysis Syndrome in Patients With Multiple Myeloma During Bortezomib Treatment","display_name":"Management of Tumor Lysis Syndrome in Patients With Multiple Myeloma During Bortezomib Treatment","publication_year":2015,"publication_date":"2015-01-30","ids":{"openalex":"https://openalex.org/W1976995337","doi":"https://doi.org/10.1188/15.cjon.e4-e7","mag":"1976995337","pmid":"https://pubmed.ncbi.nlm.nih.gov/25689664"},"language":"en","primary_location":{"id":"doi:10.1188/15.cjon.e4-e7","doi":"https://doi.org/10.1188/15.cjon.e4-e7","is_oa":false,"landing_page_url":"https://doi.org/10.1188/15.cjon.e4-e7","pdf_url":null,"source":{"id":"https://openalex.org/S203399934","display_name":"Clinical journal of oncology nursing","issn_l":"1092-1095","issn":["1092-1095","1538-067X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315848","host_organization_name":"Oncology Nursing Society","host_organization_lineage":["https://openalex.org/P4310315848"],"host_organization_lineage_names":["Oncology Nursing Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of Oncology Nursing","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100336067","display_name":"Li Wang","orcid":"https://orcid.org/0000-0002-6253-9453","observed_orcids":["https://orcid.org/0000-0002-6253-9453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032287053","display_name":"Yuan Jian","orcid":"https://orcid.org/0000-0003-4833-415X","observed_orcids":["https://orcid.org/0000-0003-4833-415X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Jian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018889104","display_name":"Guangzhong Yang","orcid":"https://orcid.org/0000-0002-7289-5806","observed_orcids":["https://orcid.org/0000-0002-7289-5806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangzhong Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021286","display_name":"Wen Xiu Gao","orcid":"https://orcid.org/0000-0003-4600-099X","observed_orcids":["https://orcid.org/0000-0003-4600-099X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yin Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059806151","display_name":"Lihong Zuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lihong Zuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9757,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7719504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"19","issue":"1","first_page":"E4","last_page":"E7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12117","display_name":"Muscle and Compartmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-lysis-syndrome","display_name":"tumor lysis syndrome","score":1.0},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":1.0},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/high-risk-patient-identification","display_name":"high-risk patient identification","score":0.7329999804496765},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.6610000133514404},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2779788671","wikidata":"https://www.wikidata.org/wiki/Q998803","display_name":"Tumor lysis syndrome","level":3,"score":0.954075276851654},{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.9510904550552368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.820308268070221},{"id":"https://openalex.org/C2780243291","wikidata":"https://www.wikidata.org/wiki/Q605259","display_name":"Hyperkalemia","level":2,"score":0.7918946743011475},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.7263103723526001},{"id":"https://openalex.org/C2778939600","wikidata":"https://www.wikidata.org/wiki/Q3088229","display_name":"Rasburicase","level":4,"score":0.6234921813011169},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6166112422943115},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.6129308938980103},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5951038002967834},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5435571074485779},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5416517853736877},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5401822924613953},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4264678359031677},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.42493557929992676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3790133595466614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32693928480148315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27276647090911865},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.23775029182434082},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20290887355804443},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17808136343955994},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1604466736316681},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13682779669761658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10304924845695496},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07942840456962585}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015275","descriptor_name":"Tumor Lysis Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015275","descriptor_name":"Tumor Lysis Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015275","descriptor_name":"Tumor Lysis Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1188/15.cjon.e4-e7","doi":"https://doi.org/10.1188/15.cjon.e4-e7","is_oa":false,"landing_page_url":"https://doi.org/10.1188/15.cjon.e4-e7","pdf_url":null,"source":{"id":"https://openalex.org/S203399934","display_name":"Clinical journal of oncology nursing","issn_l":"1092-1095","issn":["1092-1095","1538-067X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315848","host_organization_name":"Oncology Nursing Society","host_organization_lineage":["https://openalex.org/P4310315848"],"host_organization_lineage_names":["Oncology Nursing Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of Oncology Nursing","raw_type":"journal-article"},{"id":"pmid:25689664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25689664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical journal of oncology nursing","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1740327132","https://openalex.org/W1967251991","https://openalex.org/W1974665742","https://openalex.org/W1982946927","https://openalex.org/W2037363235","https://openalex.org/W2054783695","https://openalex.org/W2080515779","https://openalex.org/W2084809606","https://openalex.org/W2109333045","https://openalex.org/W2122479144","https://openalex.org/W2134138207","https://openalex.org/W2332830512","https://openalex.org/W2609515889"],"related_works":["https://openalex.org/W2098542167","https://openalex.org/W3102494556","https://openalex.org/W2080515779","https://openalex.org/W2013231175","https://openalex.org/W2732250186","https://openalex.org/W2418014582","https://openalex.org/W2529281660","https://openalex.org/W2560339482","https://openalex.org/W2084809606","https://openalex.org/W2122623412"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tumor":[1],"lysis":[2],"syndrome":[3],"(TLS)":[4],"is":[5,19,26,71,122],"a":[6,90],"severe,":[7],"life-threatening":[8],"complication":[9],"that":[10],"typically":[11],"occurs":[12],"in":[13,21,52,59],"highly":[14],"proliferative":[15],"malignancies.":[16],"Although":[17],"TLS":[18,46,98,130],"unusual":[20],"multiple":[22],"myeloma":[23],"(MM),":[24],"it":[25],"still":[27],"associated":[28],"with":[29,42,54,94,104,108,120],"significant":[30,77],"morbidity.":[31],"Bortezomib":[32],"has":[33],"been":[34],"widely":[35],"used":[36],"for":[37,80],"the":[38,81,87,135],"treatment":[39,138],"of":[40,68,83,89,117,137],"MM":[41,55,95,105,121],"encouraging":[43],"results,":[44],"but":[45],"seems":[47],"to":[48,72],"occur":[49],"more":[50],"frequently":[51],"patients":[53,60,93,119],"receiving":[56,61],"bortezomib":[57,100],"than":[58],"other":[62],"conventional":[63],"agents.":[64],"OBJECTIVES:":[65],"The":[66,112],"purpose":[67],"this":[69],"article":[70],"present":[73],"and":[74,115,125,133],"examine":[75],"several":[76],"risk":[78],"factors":[79],"development":[82],"TLS,":[84],"based":[85],"on":[86],"results":[88],"study":[91],"involving":[92],"who":[96],"developed":[97],"during":[99],"treatment.":[101],"METHODS:":[102],"Patients":[103],"were":[106],"treated":[107],"bortezomib-containing":[109],"regimens.":[110],"FINDINGS:":[111],"early":[113],"identification":[114],"intervention":[116],"high-risk":[118],"imperative.":[123],"Timely":[124],"efficient":[126],"management":[127],"could":[128],"decrease":[129],"incidence":[131],"rates":[132],"improve":[134],"efficacy":[136],"outcomes.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
