{"id":"https://openalex.org/W1976995280","doi":"https://doi.org/10.1073/pnas.0507408102","title":"Heat-shock protein 60 is required for blastema formation and maintenance during regeneration","display_name":"Heat-shock protein 60 is required for blastema formation and maintenance during regeneration","publication_year":2005,"publication_date":"2005-10-04","ids":{"openalex":"https://openalex.org/W1976995280","doi":"https://doi.org/10.1073/pnas.0507408102","mag":"1976995280","pmid":"https://pubmed.ncbi.nlm.nih.gov/16204379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253607"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0507408102","doi":"https://doi.org/10.1073/pnas.0507408102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0507408102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253607","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102970447","display_name":"Shinji Makino","orcid":"https://orcid.org/0000-0003-3365-3369","observed_orcids":["https://orcid.org/0000-0003-3365-3369"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shinji Makino","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086833689","display_name":"Geoffrey G. Whitehead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Geoffrey G. Whitehead","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000067953","display_name":"Ching\u2010Ling Lien","orcid":"https://orcid.org/0000-0002-5100-9780","observed_orcids":["https://orcid.org/0000-0002-5100-9780"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ching-Ling Lien","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778890","display_name":"Soo Jeong Kim","orcid":"https://orcid.org/0000-0002-6640-9445","observed_orcids":["https://orcid.org/0000-0002-6640-9445"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Soo Kim","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057408036","display_name":"Payal Jhawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Payal Jhawar","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066849215","display_name":"Akane Kono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Akane Kono","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011704335","display_name":"Yasushi Kawata","orcid":"https://orcid.org/0000-0002-2744-1506","observed_orcids":["https://orcid.org/0000-0002-2744-1506"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yasushi Kawata","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103550127","display_name":"Mark T. Keating","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Mark T. Keating","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, and Departments of Pediatrics and Cell Biology, Harvard Medical School, Boston, MA 02115; and Department of Biotechnology, Faculty of Engineering, and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Koyama-Minami, Tottori 680-8552, Japan","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9162,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.897997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"102","issue":"41","first_page":"14599","last_page":"14604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.7103999853134155,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock-protein-60","display_name":"heat shock protein 60","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blastema-formation","display_name":"blastema formation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fin-regeneration","display_name":"fin regeneration","score":0.7889999747276306},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6200000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.8889999985694885},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.7329999804496765},{"id":"https://openalex.org/keywords/positional-cloning","display_name":"positional cloning","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C78214289","wikidata":"https://www.wikidata.org/wiki/Q882043","display_name":"Blastema","level":3,"score":0.9897024631500244},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.808083176612854},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.8068804144859314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6959716081619263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6819890737533569},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6031699180603027},{"id":"https://openalex.org/C146621620","wikidata":"https://www.wikidata.org/wiki/Q24771589","display_name":"HSP60","level":5,"score":0.4994819164276123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24499520659446716},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.22337424755096436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06013950705528259}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018834","descriptor_name":"Chaperonin 60","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0507408102","doi":"https://doi.org/10.1073/pnas.0507408102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0507408102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1253607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253607","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:16204379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16204379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1253607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253607","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4126683139","display_name":null,"funder_award_id":"HL 02-027","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000877371","display_name":"Research Methods in Pediatric Cardiovascular Disease","funder_award_id":"T32HL007572","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1483162601","https://openalex.org/W1591714343","https://openalex.org/W1965071336","https://openalex.org/W1966898852","https://openalex.org/W1971012459","https://openalex.org/W1971521446","https://openalex.org/W1976927391","https://openalex.org/W1978440190","https://openalex.org/W1983244186","https://openalex.org/W1984455746","https://openalex.org/W1999710123","https://openalex.org/W2001627351","https://openalex.org/W2002195659","https://openalex.org/W2003742149","https://openalex.org/W2005462392","https://openalex.org/W2017334338","https://openalex.org/W2022087854","https://openalex.org/W2059485167","https://openalex.org/W2062539443","https://openalex.org/W2063171792","https://openalex.org/W2081422975","https://openalex.org/W2081447029","https://openalex.org/W2085046609","https://openalex.org/W2092763872","https://openalex.org/W2100920433","https://openalex.org/W2105824459","https://openalex.org/W2110998704","https://openalex.org/W2126747203","https://openalex.org/W2128625450","https://openalex.org/W2137590150","https://openalex.org/W2142338805","https://openalex.org/W2145736817","https://openalex.org/W2169604969","https://openalex.org/W7112136558"],"related_works":["https://openalex.org/W4232819021","https://openalex.org/W2105824459","https://openalex.org/W4401814445","https://openalex.org/W2034493473","https://openalex.org/W2100920433","https://openalex.org/W2050371513","https://openalex.org/W280035832","https://openalex.org/W2138980520","https://openalex.org/W2006870892","https://openalex.org/W2013673830"],"abstract_inverted_index":{"Zebrafish":[0],"fin":[1,81],"regeneration":[2,82,85],"requires":[3],"the":[4,155],"formation":[5,45,61,132,156],"and":[6,27,62,102,123,136,142,157],"maintenance":[7,158],"of":[8,43,133,159],"blastema":[9,44,60,73,92,134],"cells.":[10,146],"Blastema":[11],"cells":[12,18,35],"are":[13,25,28],"not":[14,47],"derived":[15],"from":[16,109],"stem":[17],"but":[19],"behave":[20],"as":[21],"such,":[22],"because":[23],"they":[24],"slow-cycling":[26],"thought":[29],"to":[30,70,90,97,139],"provide":[31],"rapidly":[32],"proliferating":[33],"daughter":[34],"that":[36,52,106,150],"drive":[37],"regenerative":[38],"outgrowth.":[39],"The":[40],"molecular":[41],"basis":[42],"is":[46,57,129,152],"understood.":[48],"Here,":[49],"we":[50],"show":[51],"heat-shock":[53],"protein":[54],"60":[55],"(hsp60)":[56],"required":[58,153],"for":[59,154],"maintenance.":[63],"We":[64],"used":[65],"a":[66,75,110],"chemical":[67],"mutagenesis":[68],"screen":[69],"identify":[71],"no":[72],"(nbl),":[74],"zebrafish":[76],"mutant":[77],"with":[78],"an":[79],"early":[80],"defect.":[83],"Fin":[84],"failed":[86,96],"in":[87,114,121,144],"nbl":[88,94,107],"due":[89],"defective":[91],"formation.":[93],"also":[95],"regenerate":[98],"hearts.":[99],"Positional":[100],"cloning":[101],"mutational":[103],"analyses":[104],"revealed":[105],"results":[108],"V324E":[111],"missense":[112],"mutation":[113,117],"hsp60.":[115],"This":[116],"reduced":[118],"hsp60":[119,127,151],"function":[120],"binding":[122],"refolding":[124],"denatured":[125],"proteins.":[126],"expression":[128],"increased":[130],"during":[131],"cells,":[135],"dysfunction":[137],"leads":[138],"mitochondrial":[140],"defects":[141],"apoptosis":[143],"these":[145],"These":[147],"data":[148],"indicate":[149],"regenerating":[160],"tissue.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
