{"id":"https://openalex.org/W1976936848","doi":"https://doi.org/10.1099/0022-1317-64-3-743","title":"Inhibition of Vesicular Stomatitis Virus RNA Synthesis by 2',3'-Dideoxycytidine 5'-Triphosphate","display_name":"Inhibition of Vesicular Stomatitis Virus RNA Synthesis by 2',3'-Dideoxycytidine 5'-Triphosphate","publication_year":1983,"publication_date":"1983-03-01","ids":{"openalex":"https://openalex.org/W1976936848","doi":"https://doi.org/10.1099/0022-1317-64-3-743","mag":"1976936848","pmid":"https://pubmed.ncbi.nlm.nih.gov/6298355"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-64-3-743","doi":"https://doi.org/10.1099/0022-1317-64-3-743","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-64-3-743","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036655213","display_name":"John T. Patton","orcid":"https://orcid.org/0000-0003-1572-0732","observed_orcids":["https://orcid.org/0000-0003-1572-0732"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. T. Patton","raw_affiliation_strings":["Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110940602","display_name":"Nancy Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. L. Davis","raw_affiliation_strings":["Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057682074","display_name":"Gail Williams Wertz","orcid":"https://orcid.org/0000-0002-7562-7292","observed_orcids":["https://orcid.org/0000-0002-7562-7292"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. W. Wertz","raw_affiliation_strings":["Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, Medical School, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.12057682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"3","first_page":"743","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antiviral-nucleoside-analogues","display_name":"antiviral nucleosides","score":0.6729999780654907},{"id":"https://openalex.org/keywords/rna-synthesis-inhibition","display_name":"RNA synthesis inhibition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/viral-rna-replication","display_name":"viral RNA replication","score":0.9520000219345093},{"id":"https://openalex.org/keywords/viral-transcription","display_name":"viral transcription","score":0.8529999852180481},{"id":"https://openalex.org/keywords/viral-translation","display_name":"viral protein synthesis","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.8450506925582886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7588509321212769},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7115420699119568},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6520586013793945},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5749623775482178},{"id":"https://openalex.org/C2777974785","wikidata":"https://www.wikidata.org/wiki/Q1356983","display_name":"Rhabdoviridae","level":4,"score":0.5360235571861267},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5140634775161743},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5016870498657227},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49552977085113525},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4840918779373169},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4150139093399048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33406883478164673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09709826111793518},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003845","descriptor_name":"Deoxycytosine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054306","descriptor_name":"Dideoxynucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1099/0022-1317-64-3-743","doi":"https://doi.org/10.1099/0022-1317-64-3-743","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-64-3-743","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:6298355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6298355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.555.5026","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.555.5026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://vir.sgmjournals.org/content/64/3/743.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1494760851","https://openalex.org/W1516534778","https://openalex.org/W1868144737","https://openalex.org/W2008347835","https://openalex.org/W2028622090","https://openalex.org/W2054216182","https://openalex.org/W2091659670","https://openalex.org/W2121723577"],"related_works":["https://openalex.org/W3172727636","https://openalex.org/W1874140622","https://openalex.org/W4385251581","https://openalex.org/W2015708385","https://openalex.org/W1546116627","https://openalex.org/W2023392075","https://openalex.org/W1592709104","https://openalex.org/W2074490966","https://openalex.org/W2061730408","https://openalex.org/W1633640294"],"abstract_inverted_index":{"The":[0,99],"ability":[1],"of":[2,13,44,57,72,101,113,147],"the":[3,107,126,142],"compound":[4,131],"2',3'-dideoxycytidine":[5],"5'-triphosphate":[6],"(ddCTP)":[7],"to":[8,96],"serve":[9],"as":[10,94,117],"an":[11,20],"inhibitor":[12],"viral":[14,81],"RNA":[15,36,60,136],"synthesis":[16,37,89,137,144],"was":[17,38,76,90],"examined":[18],"using":[19],"in":[21,47,55,138],"vitro":[22,139],"system":[23],"that":[24,132],"supports":[25],"vesicular":[26],"stomatitis":[27],"virus":[28],"(VSV)":[29],"protein":[30,82,88,115],"synthesis,":[31],"transcription":[32,63],"and":[33,42,52,62,145],"replication.":[34],"Viral":[35],"inhibited":[39,65,91],"by":[40,67,92,119],"87":[41],"98%":[43],"control,":[45],"respectively,":[46],"reactions":[48],"containing":[49],"1":[50,73],"mM-":[51],"10":[53,85],"mM-ddCTP":[54],"place":[56],"CTP.":[58],"VSV":[59,135],"replication":[61],"were":[64],"equally":[66],"ddCTP.":[68],"At":[69],"a":[70,130],"concentration":[71],"mM-ddCTP,":[74,86],"there":[75],"no":[77,104],"inhibitory":[78],"effect":[79,105],"on":[80,106,121],"synthesis;":[83],"at":[84],"total":[87],"30%":[93],"compared":[95],"control":[97],"reactions.":[98],"presence":[100],"ddCTP":[102],"had":[103],"size":[108],"or":[109],"relative":[110],"molar":[111],"amounts":[112],"each":[114],"synthesized":[116],"analysed":[118],"electrophoresis":[120],"polyacrylamide":[122],"gels.":[123],"This":[124],"is":[125],"first":[127],"report":[128],"describing":[129],"will":[133],"inhibit":[134],"without":[140],"compromising":[141],"concurrent":[143],"modification":[146],"proteins.":[148]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}