{"id":"https://openalex.org/W1976927005","doi":"https://doi.org/10.1073/pnas.92.7.2672","title":"Functional estrogen receptors in a human preosteoclastic cell line.","display_name":"Functional estrogen receptors in a human preosteoclastic cell line.","publication_year":1995,"publication_date":"1995-03-28","ids":{"openalex":"https://openalex.org/W1976927005","doi":"https://doi.org/10.1073/pnas.92.7.2672","mag":"1976927005","pmid":"https://pubmed.ncbi.nlm.nih.gov/7708703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/42280"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.7.2672","doi":"https://doi.org/10.1073/pnas.92.7.2672","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.7.2672","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC42280","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066978573","display_name":"Gianna Fiorelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Fiorelli","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071603809","display_name":"Francesca Gori","orcid":"https://orcid.org/0000-0001-5685-8303","observed_orcids":["https://orcid.org/0000-0001-5685-8303"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Gori","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070109399","display_name":"Marco Petilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Petilli","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032540503","display_name":"Annalisa Tanini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Tanini","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Benvenuti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Benvenuti","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112955896","display_name":"M. Serio","orcid":"https://orcid.org/0009-0008-7447-2525","observed_orcids":["https://orcid.org/0009-0008-7447-2525"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Serio","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108411478","display_name":"P. A. Bernabei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Bernabei","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055069129","display_name":"Maria Luisa Brandi","orcid":"https://orcid.org/0000-0002-8741-0592","observed_orcids":["https://orcid.org/0000-0002-8741-0592"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M L Brandi","raw_affiliation_strings":["Department of Clinical Physiopathology, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiopathology, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":null,"apc_paid":null,"fwci":2.5508,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91964889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"92","issue":"7","first_page":"2672","last_page":"2676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.925000011920929},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.6990000009536743},{"id":"https://openalex.org/keywords/progesterone-binding","display_name":"progesterone binding","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.871999979019165},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6662166714668274},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5682880878448486},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.5676259994506836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5281531810760498},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5113177299499512},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.4956580400466919},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.49513283371925354},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4699048399925232},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4668256640434265},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.46618741750717163},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4363335371017456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34212642908096313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25175565481185913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17360472679138184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1623000204563141},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000091344","descriptor_name":"Filaggrin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.92.7.2672","doi":"https://doi.org/10.1073/pnas.92.7.2672","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.7.2672","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:82846","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC42280","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:42280","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/42280","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:7708703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7708703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/341353","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/341353","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3185155393","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/80008226648","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:82846","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC42280","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W8541401","https://openalex.org/W1497865291","https://openalex.org/W1544298021","https://openalex.org/W1585098875","https://openalex.org/W1637034742","https://openalex.org/W1906197854","https://openalex.org/W1976968355","https://openalex.org/W1981306061","https://openalex.org/W1992313090","https://openalex.org/W1996028579","https://openalex.org/W1996758205","https://openalex.org/W2001269969","https://openalex.org/W2003485678","https://openalex.org/W2018289835","https://openalex.org/W2043144329","https://openalex.org/W2062729355","https://openalex.org/W2064779138","https://openalex.org/W2070019586","https://openalex.org/W2081604537","https://openalex.org/W2092953530","https://openalex.org/W2095899140","https://openalex.org/W2100837269","https://openalex.org/W2104858135","https://openalex.org/W2134812217","https://openalex.org/W2140086733","https://openalex.org/W2142365365","https://openalex.org/W2153550326","https://openalex.org/W2160471003"],"related_works":["https://openalex.org/W7024363449","https://openalex.org/W2043144329","https://openalex.org/W2062937887","https://openalex.org/W2062729355","https://openalex.org/W2001572619","https://openalex.org/W7064261260","https://openalex.org/W2081094671","https://openalex.org/W2070458350","https://openalex.org/W3185155393","https://openalex.org/W1968552040"],"abstract_inverted_index":{"The":[0],"primary":[1],"biological":[2],"effect":[3],"of":[4,53,60,84,121,137,155,163,184,193,217],"the":[5,44,71,129,164,185,196,200,205,210],"estrogen":[6,55,201,245],"estradiol-17":[7],"beta":[8,10,22,86,146,173,225],"(17":[9],"E2)":[11],"on":[12,34],"bone":[13,17],"is":[14,36],"to":[15,88,133,157,233,236],"decrease":[16],"resorption.":[18],"However,":[19],"whether":[20],"17":[21,145,172,224],"E2":[23,87,147,174,226],"affects":[24],"osteoclast":[25],"differentiation":[26],"or":[27,30,142],"function":[28],"directly":[29],"through":[31],"its":[32],"action":[33],"osteoblasts":[35],"unclear.":[37],"To":[38],"investigate":[39],"this":[40],"question":[41],"we":[42],"examined":[43],"human":[45,72,134],"preosteoclastic":[46],"cell":[47,107,180],"line":[48],"FLG":[49,77,218],"29.1":[50,78,159,219],"for":[51,70,204,244],"evidence":[52],"functional":[54],"receptors":[56],"(ERs).":[57],"Southern":[58],"blotting":[59,127],"reverse":[61],"transcription-PCR":[62],"amplification":[63],"products":[64],"with":[65,94,113,128,139,166,195,221],"a":[66,149,241],"32P-labeled":[67],"cDNA":[68],"probe":[69],"ER":[73,81,186],"mRNA":[74],"demonstrated":[75],"that":[76],"cells":[79,138,165,194,220],"express":[80],"mRNA.":[82],"Binding":[83],"[3H]17":[85],"nuclear":[89],"ERs":[90,110],"was":[91,188],"steroid":[92],"specific":[93,153],"approximately":[95,101],"400":[96],"saturable,":[97],"high":[98],"affinity":[99],"(Kd":[100],"1":[102],"nM)":[103],"binding":[104,154],"sites":[105],"per":[106],"nucleus.":[108],"Nuclear":[109],"covalently":[111],"labeled":[112],"[3H]tamoxifen":[114],"aziridine":[115],"showed":[116],"an":[117],"apparent":[118],"molecular":[119],"weight":[120],"65,000":[122],"by":[123,190],"SDS/PAGE":[124],"and":[125,151,161,169,209],"Western":[126],"D75":[130],"monoclonal":[131],"antibody":[132],"ER.":[135],"Pretreatment":[136],"0.1,":[140],"1.0,":[141],"10":[143,167,222],"nM":[144,168,171,223],"induced":[148],"dose-":[150],"time-dependent":[152],"progesterone":[156],"FGL":[158],"cells,":[160],"stimulation":[162],"100":[170],"significantly":[175],"(P":[176],"<":[177],"0.05)":[178],"reduced":[179],"proliferation.":[181],"Transcriptional":[182],"activity":[183],"gene":[187,208],"detected":[189],"transient":[191],"transfection":[192],"pERE-BLCAT":[197],"plasmid":[198],"containing":[199],"response":[202],"element":[203],"vitellogenin":[206],"A2":[207],"bacterial":[211],"chloramphenicol":[212],"acetyltransferase":[213,229],"reporter":[214],"gene.":[215],"Treatment":[216],"increased":[227],"chloroamphenicol":[228],"expression":[230],"from":[231],"5-":[232],"29-fold":[234],"compared":[235],"controls.":[237],"These":[238],"observations":[239],"suggest":[240],"potential":[242],"role":[243],"in":[246],"osteoclastogenesis.":[247]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
