{"id":"https://openalex.org/W1976908855","doi":"https://doi.org/10.3928/00485713-20141208-05","title":"Early Development of Monoamine Oxidase Inhibitors","display_name":"Early Development of Monoamine Oxidase Inhibitors","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W1976908855","doi":"https://doi.org/10.3928/00485713-20141208-05","mag":"1976908855"},"language":"en","primary_location":{"id":"doi:10.3928/00485713-20141208-05","doi":"https://doi.org/10.3928/00485713-20141208-05","is_oa":false,"landing_page_url":"https://doi.org/10.3928/00485713-20141208-05","pdf_url":null,"source":{"id":"https://openalex.org/S59157943","display_name":"Psychiatric Annals","issn_l":"0048-5713","issn":["0048-5713","1938-2456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800624","host_organization_name":"Slack Incorporated (United States)","host_organization_lineage":["https://openalex.org/P4320800624"],"host_organization_lineage_names":["Slack Incorporated (United States)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Annals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108395853","display_name":"Donald F. Klein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald F. Klein","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031437808","display_name":"Peter C. Arden","orcid":"https://orcid.org/0000-0003-0228-5532","observed_orcids":["https://orcid.org/0000-0003-0228-5532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C. Arden","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09764635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"12","first_page":"563","last_page":"566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12666","display_name":"Historical Psychiatry and Medical Practices","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hypertensive-crisis","display_name":"hypertensive crisis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.9700000286102295},{"id":"https://openalex.org/keywords/moclobemide","display_name":"moclobemide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.4519999921321869},{"id":"https://openalex.org/keywords/anxiolytic-treatment","display_name":"anxiolytic treatment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/history-of-psychopharmacology","display_name":"history of psychopharmacology","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2780237459","wikidata":"https://www.wikidata.org/wiki/Q421934","display_name":"Moclobemide","level":4,"score":0.7847477197647095},{"id":"https://openalex.org/C2776134090","wikidata":"https://www.wikidata.org/wiki/Q47495783","display_name":"Selegiline","level":4,"score":0.6676326990127563},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5950040817260742},{"id":"https://openalex.org/C2778630814","wikidata":"https://www.wikidata.org/wiki/Q410954","display_name":"Monoamine oxidase inhibitor","level":4,"score":0.5147671699523926},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.511459469795227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4755786955356598},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4630461037158966},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4384611248970032},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3294614851474762},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.2765062153339386},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.2262023687362671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18993538618087769},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08380401134490967},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07488030195236206},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3928/00485713-20141208-05","doi":"https://doi.org/10.3928/00485713-20141208-05","is_oa":false,"landing_page_url":"https://doi.org/10.3928/00485713-20141208-05","pdf_url":null,"source":{"id":"https://openalex.org/S59157943","display_name":"Psychiatric Annals","issn_l":"0048-5713","issn":["0048-5713","1938-2456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800624","host_organization_name":"Slack Incorporated (United States)","host_organization_lineage":["https://openalex.org/P4320800624"],"host_organization_lineage_names":["Slack Incorporated (United States)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Annals","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W98026431","https://openalex.org/W137738105","https://openalex.org/W332531289","https://openalex.org/W1965983395","https://openalex.org/W1972093721","https://openalex.org/W1977572292","https://openalex.org/W2003798406","https://openalex.org/W2025071399","https://openalex.org/W2025390921","https://openalex.org/W2032335049","https://openalex.org/W2034761784","https://openalex.org/W2068793215","https://openalex.org/W2073609038","https://openalex.org/W2074703267","https://openalex.org/W2077844594","https://openalex.org/W2082599991","https://openalex.org/W2087962260","https://openalex.org/W2089642713","https://openalex.org/W2091388857","https://openalex.org/W2104579005","https://openalex.org/W2143045290","https://openalex.org/W2317384284","https://openalex.org/W2328979380","https://openalex.org/W2409813829","https://openalex.org/W2426764671","https://openalex.org/W2467504248","https://openalex.org/W2467792582"],"related_works":["https://openalex.org/W3168207480","https://openalex.org/W2487902979","https://openalex.org/W2152629554","https://openalex.org/W102145562","https://openalex.org/W2092504356","https://openalex.org/W165151045","https://openalex.org/W4234901000","https://openalex.org/W191593235","https://openalex.org/W2284355027","https://openalex.org/W2068818066"],"abstract_inverted_index":{"This":[0],"article":[1],"reviews":[2],"the":[3,15,19,30,109,151],"history":[4],"of":[5,23,43,54,58,79,84,94,144,148],"monoamine":[6],"oxidase":[7],"inhibitors":[8],"(MAOIs)":[9],"from":[10],"their":[11,24,87],"initial":[12],"synthesis":[13],"in":[14,106],"early":[16],"1900s":[17],"until":[18],"present.":[20],"The":[21,41,146],"recognition":[22],"potential":[25],"psychiatric":[26,95],"benefits":[27],"came":[28],"when":[29],"only":[31],"available":[32],"effective":[33,117],"treatment":[34,138],"for":[35,123],"depressed":[36,124],"patients":[37,127],"was":[38],"seizure":[39],"therapy.":[40],"introduction":[42],"medications":[44],"to":[45],"treat":[46],"depressive":[47],"illness":[48],"heralded":[49],"an":[50],"exciting":[51],"new":[52],"era":[53],"psychopharmacology;":[55],"however,":[56],"reports":[57],"paroxysmal":[59],"hypertensive":[60],"crises":[61],"dampened":[62],"enthusiasm.":[63],"Dietary":[64],"restrictions":[65],"and":[66,76,150],"drug":[67],"interactions":[68],"with":[69,140],"MAOIs":[70,85,115],"are":[71],"now":[72],"defined,":[73],"but":[74],"apprehension":[75],"a":[77,91,141],"lack":[78],"familiarity":[80],"cause":[81],"infrequent":[82],"prescribing":[83],"despite":[86],"powerful":[88],"effect":[89],"across":[90],"wide":[92],"range":[93],"disorders.":[96],"As":[97],"demonstrated":[98],"at":[99,134],"Columbia":[100],"University\u2019s":[101],"Depression":[102],"Evaluation":[103],"Service,":[104],"founded":[105],"1977":[107],"by":[108],"late":[110],"Frederic":[111],"M.":[112],"Quitkin,":[113],"MD,":[114],"remain":[116],"agents":[118],"that":[119],"should":[120],"be":[121],"considered":[122],"or":[125],"anxious":[126],"who":[128],"have":[129],"not":[130],"improved":[131],"sufficiently":[132],"following":[133],"least":[135],"one":[136],"prior":[137],"attempt":[139],"different":[142],"class":[143],"medication.":[145],"use":[147],"moclobemide":[149],"selegiline":[152],"transdermal":[153],"system":[154],"as":[155],"primary":[156],"treatments":[157],"requires":[158],"clarification.":[159],"[":[160],"Psychiatr":[161],"Ann":[162],".":[163],"2014;44(12):563\u2013566.]":[164]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}