{"id":"https://openalex.org/W1976878552","doi":"https://doi.org/10.1016/j.taap.2003.11.031","title":"The developmental toxicity of perfluoroalkyl acids and their derivatives","display_name":"The developmental toxicity of perfluoroalkyl acids and their derivatives","publication_year":2004,"publication_date":"2004-04-09","ids":{"openalex":"https://openalex.org/W1976878552","doi":"https://doi.org/10.1016/j.taap.2003.11.031","mag":"1976878552","pmid":"https://pubmed.ncbi.nlm.nih.gov/15236955"},"language":"en","primary_location":{"id":"doi:10.1016/j.taap.2003.11.031","doi":"https://doi.org/10.1016/j.taap.2003.11.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2003.11.031","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103282843","display_name":"Christopher S. Lau","orcid":"https://orcid.org/0000-0002-3774-8309","observed_orcids":["https://orcid.org/0000-0002-3774-8309"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Lau","raw_affiliation_strings":["Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. lau.christopher@epa.gov","Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. lau.christopher@epa.gov","institution_ids":["https://openalex.org/I1302368450"]},{"raw_affiliation_string":"Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046872280","display_name":"John L. Butenhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340755506","display_name":"3M (United States)","ror":"https://ror.org/00mgss748","country_code":"US","type":"company","lineage":["https://openalex.org/I1340755506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L Butenhoff","raw_affiliation_strings":["3M Medical Department, St. Paul, MN 55144, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3M Medical Department, St. Paul, MN 55144, USA","institution_ids":["https://openalex.org/I1340755506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083702469","display_name":"John M. Rogers","orcid":"https://orcid.org/0000-0002-5881-1768","observed_orcids":["https://orcid.org/0000-0002-5881-1768"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M Rogers","raw_affiliation_strings":["Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":3.0977,"has_fulltext":false,"cited_by_count":873,"citation_normalized_percentile":{"value":0.94117647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"198","issue":"2","first_page":"231","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfluoroalkyl-acids","display_name":"perfluoroalkyl acids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/perfluorooctane-sulfonate","display_name":"PFOS","score":0.9100000262260437},{"id":"https://openalex.org/keywords/perfluorooctanoic-acid","display_name":"perfluorooctanoic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.7699999809265137},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.890999972820282},{"id":"https://openalex.org/keywords/human-health-risk-assessment","display_name":"human health risk assessment","score":0.7839999794960022},{"id":"https://openalex.org/keywords/biomonitoring","display_name":"biomonitoring","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2775979320","wikidata":"https://www.wikidata.org/wiki/Q418348","display_name":"Perfluorooctanoic acid","level":2,"score":0.978507936000824},{"id":"https://openalex.org/C2781314072","wikidata":"https://www.wikidata.org/wiki/Q421426","display_name":"Perfluorooctane","level":4,"score":0.9256511926651001},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.7003627419471741},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4769676625728607},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.46419110894203186},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.45912161469459534},{"id":"https://openalex.org/C99432707","wikidata":"https://www.wikidata.org/wiki/Q3427345","display_name":"Reproductive toxicity","level":3,"score":0.4209875166416168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39436018466949463},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3401116132736206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2642883062362671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2168920636177063},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18083983659744263},{"id":"https://openalex.org/C2778894819","wikidata":"https://www.wikidata.org/wiki/Q922718","display_name":"Sulfonate","level":3,"score":0.16685736179351807},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0711895227432251},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.taap.2003.11.031","doi":"https://doi.org/10.1016/j.taap.2003.11.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2003.11.031","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:15236955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15236955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W606530750","https://openalex.org/W624161006","https://openalex.org/W1662143292","https://openalex.org/W1939557710","https://openalex.org/W1964658975","https://openalex.org/W1969107063","https://openalex.org/W1969362017","https://openalex.org/W1972258539","https://openalex.org/W1975106712","https://openalex.org/W1976393083","https://openalex.org/W1976636430","https://openalex.org/W1976770880","https://openalex.org/W1977219469","https://openalex.org/W1978328976","https://openalex.org/W1978927533","https://openalex.org/W1979452793","https://openalex.org/W1980296829","https://openalex.org/W1987040388","https://openalex.org/W1995297514","https://openalex.org/W1996696969","https://openalex.org/W1997910649","https://openalex.org/W1998759224","https://openalex.org/W1999779807","https://openalex.org/W2001269266","https://openalex.org/W2004024071","https://openalex.org/W2006225130","https://openalex.org/W2007370532","https://openalex.org/W2009433991","https://openalex.org/W2011618923","https://openalex.org/W2011728309","https://openalex.org/W2012861620","https://openalex.org/W2017755453","https://openalex.org/W2019301627","https://openalex.org/W2019745937","https://openalex.org/W2021746554","https://openalex.org/W2022879961","https://openalex.org/W2023725788","https://openalex.org/W2024165817","https://openalex.org/W2025868160","https://openalex.org/W2031838659","https://openalex.org/W2035844262","https://openalex.org/W2035966708","https://openalex.org/W2040393913","https://openalex.org/W2042207206","https://openalex.org/W2042880426","https://openalex.org/W2043672781","https://openalex.org/W2044995263","https://openalex.org/W2046719094","https://openalex.org/W2049161116","https://openalex.org/W2049354575","https://openalex.org/W2049918076","https://openalex.org/W2051051975","https://openalex.org/W2051220320","https://openalex.org/W2052674221","https://openalex.org/W2053849036","https://openalex.org/W2056548675","https://openalex.org/W2057662606","https://openalex.org/W2058154283","https://openalex.org/W2058457626","https://openalex.org/W2059758444","https://openalex.org/W2061315918","https://openalex.org/W2062403668","https://openalex.org/W2067215286","https://openalex.org/W2069272268","https://openalex.org/W2070225924","https://openalex.org/W2070415267","https://openalex.org/W2070530203","https://openalex.org/W2072920431","https://openalex.org/W2075016249","https://openalex.org/W2076799152","https://openalex.org/W2078553897","https://openalex.org/W2078664739","https://openalex.org/W2081345559","https://openalex.org/W2082154626","https://openalex.org/W2082324328","https://openalex.org/W2084675698","https://openalex.org/W2085442777","https://openalex.org/W2086304458","https://openalex.org/W2086845313","https://openalex.org/W2087292581","https://openalex.org/W2091042719","https://openalex.org/W2092025136","https://openalex.org/W2094012249","https://openalex.org/W2094265575","https://openalex.org/W2095441746","https://openalex.org/W2098379965","https://openalex.org/W2100493261","https://openalex.org/W2101318730","https://openalex.org/W2105954461","https://openalex.org/W2111493612","https://openalex.org/W2118370058","https://openalex.org/W2120384932","https://openalex.org/W2125582966","https://openalex.org/W2127286660","https://openalex.org/W2127587781","https://openalex.org/W2134791901","https://openalex.org/W2141639631","https://openalex.org/W2142447528","https://openalex.org/W2144335264","https://openalex.org/W2165031389","https://openalex.org/W2169545575","https://openalex.org/W2200997159","https://openalex.org/W2284635619","https://openalex.org/W2405972934","https://openalex.org/W2487438858","https://openalex.org/W2496899470","https://openalex.org/W2623590535","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4250884154","https://openalex.org/W132620466","https://openalex.org/W571742238","https://openalex.org/W2167567374","https://openalex.org/W1965296879","https://openalex.org/W7100381546","https://openalex.org/W2393115278","https://openalex.org/W4400483915","https://openalex.org/W2417601985","https://openalex.org/W2088700166"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":73},{"year":2016,"cited_by_count":39},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":52},{"year":2013,"cited_by_count":57},{"year":2012,"cited_by_count":46}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}