{"id":"https://openalex.org/W1976830559","doi":"https://doi.org/10.1002/brb3.200","title":"Multi\u2010analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection","display_name":"Multi\u2010analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection","publication_year":2013,"publication_date":"2013-12-29","ids":{"openalex":"https://openalex.org/W1976830559","doi":"https://doi.org/10.1002/brb3.200","mag":"1976830559","pmid":"https://pubmed.ncbi.nlm.nih.gov/24683507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3967530"},"language":"en","primary_location":{"id":"doi:10.1002/brb3.200","doi":"https://doi.org/10.1002/brb3.200","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.200","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.200","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056010266","display_name":"Marilyn S. Huckans","orcid":"https://orcid.org/0000-0003-3643-3281","observed_orcids":["https://orcid.org/0000-0003-3643-3281"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn Huckans","raw_affiliation_strings":["Department of Psychiatry Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]},{"raw_affiliation_string":"Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"raw_affiliation_string":"Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110128930","display_name":"Bret E. Fuller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bret E. Fuller","raw_affiliation_strings":["Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]},{"raw_affiliation_string":"Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"raw_affiliation_string":"Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007266928","display_name":"Hannah Olavarria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Olavarria","raw_affiliation_strings":["Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"raw_affiliation_string":"Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103450425","display_name":"Anna W. Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna W. Sasaki","raw_affiliation_strings":["Department of Internal Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Gastroenterology Service, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, Oregon, 97239 USA","Department of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Gastroenterology Service, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]},{"raw_affiliation_string":"Department of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chang","raw_affiliation_strings":["Department of Internal Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Gastroenterology Service, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, Oregon, 97239 USA","Department of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Gastroenterology Service, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]},{"raw_affiliation_string":"Department of Internal Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546263","display_name":"Kenneth D. Flora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107577","display_name":"Oregon Clinic","ror":"https://ror.org/01eadrh05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210107577"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Flora","raw_affiliation_strings":["Portland Gastroenterology Division, Oregon Clinic, 9280 SE Sunnybrook Blvd., Clackamas, Oregon, 97015 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland Gastroenterology Division, Oregon Clinic, 9280 SE Sunnybrook Blvd., Clackamas, Oregon, 97015 USA","institution_ids":["https://openalex.org/I4210107577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072876364","display_name":"Michael Kolessar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108541056","display_name":"Pacific University Oregon","ror":"https://ror.org/03g873n36","country_code":"US","type":"education","lineage":["https://openalex.org/I108541056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Kolessar","raw_affiliation_strings":["School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA","institution_ids":["https://openalex.org/I108541056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108227230","display_name":"Daniel K\u0159\u00ed\u017e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108541056","display_name":"Pacific University Oregon","ror":"https://ror.org/03g873n36","country_code":"US","type":"education","lineage":["https://openalex.org/I108541056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kriz","raw_affiliation_strings":["School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA","institution_ids":["https://openalex.org/I108541056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040930804","display_name":"Jeanne Renee Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108541056","display_name":"Pacific University Oregon","ror":"https://ror.org/03g873n36","country_code":"US","type":"education","lineage":["https://openalex.org/I108541056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanne R. Anderson","raw_affiliation_strings":["School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Professional Psychology, Pacific University, 190 SE 8th Ave., Hillsboro, Oregon, 97123 USA","institution_ids":["https://openalex.org/I108541056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004052621","display_name":"Arthur A. Vandenbark","orcid":"https://orcid.org/0000-0002-1207-6817","observed_orcids":["https://orcid.org/0000-0002-1207-6817"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur A. Vandenbark","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Department of Neurology Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Neurology Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073950799","display_name":"Jennifer M. Loftis","orcid":"https://orcid.org/0000-0003-1773-9365","observed_orcids":["https://orcid.org/0000-0003-1773-9365"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer M. Loftis","raw_affiliation_strings":["Department of Psychiatry Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Oregon Health &amp; Science University 3181 SW Sam Jackson Park Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Research &amp; Development Service Portland VA Medical Center 3710 SW U.S. Veterans Hospital Rd. Portland Oregon 97239 USA","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"raw_affiliation_string":"Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., Portland, Oregon, 97239 USA","institution_ids":["https://openalex.org/I2803065977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073950799"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977","https://openalex.org/I4210144745"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.1058,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91311531,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"123","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.800000011920929},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.7799999713897705},{"id":"https://openalex.org/keywords/neuropsychiatric-symptoms","display_name":"neuropsychiatric symptoms","score":0.984000027179718},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":1.0},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7490000128746033},{"id":"https://openalex.org/keywords/peripheral-immune-activation","display_name":"peripheral immune activation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.717595100402832},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7088218927383423},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6950763463973999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6575371026992798},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6183164119720459},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5496007204055786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5266430377960205},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.49410536885261536},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4692639708518982},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4359491467475891},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24426159262657166},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20739400386810303},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007162","descriptor_name":"Immunoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/brb3.200","doi":"https://doi.org/10.1002/brb3.200","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.200","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.200","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2946229","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3967530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3967530","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3967530","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Behav","raw_type":"Text"},{"id":"pmid:24683507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24683507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and behavior","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/brb3.200","doi":"https://doi.org/10.1002/brb3.200","is_oa":true,"landing_page_url":"https://doi.org/10.1002/brb3.200","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.200","source":{"id":"https://openalex.org/S2764450051","display_name":"Brain and Behavior","issn_l":"2157-9032","issn":["2157-9032","2162-3279"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain and Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1299407524","display_name":null,"funder_award_id":"I01 BX002061","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G806736157","display_name":"Methamphetamine Abuse Research Center","funder_award_id":"P50DA018165","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976830559.pdf","grobid_xml":"https://content.openalex.org/works/W1976830559.grobid-xml"},"referenced_works_count":136,"referenced_works":["https://openalex.org/W63997830","https://openalex.org/W65011631","https://openalex.org/W197928352","https://openalex.org/W1489805892","https://openalex.org/W1578005020","https://openalex.org/W1604828028","https://openalex.org/W1659530875","https://openalex.org/W1837581479","https://openalex.org/W1925910633","https://openalex.org/W1932207176","https://openalex.org/W1964703018","https://openalex.org/W1965801493","https://openalex.org/W1966761389","https://openalex.org/W1969022059","https://openalex.org/W1970449746","https://openalex.org/W1971295949","https://openalex.org/W1977008707","https://openalex.org/W1978567629","https://openalex.org/W1981407617","https://openalex.org/W1981496642","https://openalex.org/W1984467626","https://openalex.org/W1985438873","https://openalex.org/W1986309539","https://openalex.org/W1987694020","https://openalex.org/W1987712806","https://openalex.org/W1992144053","https://openalex.org/W1992790530","https://openalex.org/W1992901525","https://openalex.org/W1992973534","https://openalex.org/W1993166459","https://openalex.org/W1993856151","https://openalex.org/W1995556701","https://openalex.org/W1995905351","https://openalex.org/W1997351479","https://openalex.org/W1997379610","https://openalex.org/W1997908175","https://openalex.org/W2000209446","https://openalex.org/W2002267508","https://openalex.org/W2002556051","https://openalex.org/W2002767300","https://openalex.org/W2003104968","https://openalex.org/W2003282693","https://openalex.org/W2003537536","https://openalex.org/W2003635854","https://openalex.org/W2003839387","https://openalex.org/W2003982930","https://openalex.org/W2005769638","https://openalex.org/W2007121025","https://openalex.org/W2007353040","https://openalex.org/W2013887960","https://openalex.org/W2014251711","https://openalex.org/W2014435820","https://openalex.org/W2015702984","https://openalex.org/W2015851283","https://openalex.org/W2016575029","https://openalex.org/W2020341133","https://openalex.org/W2020475548","https://openalex.org/W2021466484","https://openalex.org/W2022241882","https://openalex.org/W2024980156","https://openalex.org/W2030486359","https://openalex.org/W2032919221","https://openalex.org/W2034630933","https://openalex.org/W2035988725","https://openalex.org/W2039228835","https://openalex.org/W2041249305","https://openalex.org/W2043283741","https://openalex.org/W2046156250","https://openalex.org/W2049361817","https://openalex.org/W2049808835","https://openalex.org/W2054927298","https://openalex.org/W2056433678","https://openalex.org/W2057529515","https://openalex.org/W2058468769","https://openalex.org/W2064609814","https://openalex.org/W2065307318","https://openalex.org/W2065514214","https://openalex.org/W2067029852","https://openalex.org/W2070305087","https://openalex.org/W2070362655","https://openalex.org/W2072016770","https://openalex.org/W2072115374","https://openalex.org/W2079269850","https://openalex.org/W2079494090","https://openalex.org/W2080812988","https://openalex.org/W2080902960","https://openalex.org/W2083811181","https://openalex.org/W2085071775","https://openalex.org/W2087909308","https://openalex.org/W2089417699","https://openalex.org/W2091259554","https://openalex.org/W2091975706","https://openalex.org/W2092605566","https://openalex.org/W2093578953","https://openalex.org/W2094172517","https://openalex.org/W2098139332","https://openalex.org/W2108262852","https://openalex.org/W2109045164","https://openalex.org/W2110049985","https://openalex.org/W2114242035","https://openalex.org/W2115266735","https://openalex.org/W2116159412","https://openalex.org/W2119426911","https://openalex.org/W2121165219","https://openalex.org/W2122305679","https://openalex.org/W2122929809","https://openalex.org/W2124948463","https://openalex.org/W2128462285","https://openalex.org/W2129948883","https://openalex.org/W2130330606","https://openalex.org/W2130417276","https://openalex.org/W2134137260","https://openalex.org/W2141369175","https://openalex.org/W2146600630","https://openalex.org/W2150025265","https://openalex.org/W2150896891","https://openalex.org/W2155168373","https://openalex.org/W2159847907","https://openalex.org/W2160444372","https://openalex.org/W2163817149","https://openalex.org/W2164219261","https://openalex.org/W2168610467","https://openalex.org/W2168911501","https://openalex.org/W2172299552","https://openalex.org/W2174461387","https://openalex.org/W2181671179","https://openalex.org/W2186011291","https://openalex.org/W2245231029","https://openalex.org/W2320909684","https://openalex.org/W2407813472","https://openalex.org/W2411324313","https://openalex.org/W2417262520","https://openalex.org/W2949228608","https://openalex.org/W3171418018","https://openalex.org/W3196369884","https://openalex.org/W7074234824"],"related_works":["https://openalex.org/W2066591882","https://openalex.org/W2356419522","https://openalex.org/W2886845462","https://openalex.org/W4387780136","https://openalex.org/W2163817149","https://openalex.org/W6982334482","https://openalex.org/W2809537786","https://openalex.org/W1982338960","https://openalex.org/W2060551307","https://openalex.org/W2107683035"],"abstract_inverted_index":{"BackgroundThe":[0],"purpose":[1],"of":[2,16,26,46,53,67,147,150,178,205,216,232,235,259],"this":[3],"study":[4],"was":[5,41,105,198],"to":[6,21,42,57,64,107,133,240,249,255],"characterize":[7],"hepatitis":[8],"C":[9],"virus":[10],"(HCV)-associated":[11],"differences":[12],"in":[13,30,50,71,219,267],"the":[14,23,44,51,65,151,161,167,176,182,192,217,226,260],"expression":[15,52,231],"47":[17],"inflammatory":[18,138,172],"factors":[19,152,180,238],"and":[20,36,79,93,126,128,189,223,254],"evaluate":[22,43,108],"potential":[24],"role":[25,45],"peripheral":[27],"immune":[28,47,179,208,237],"activation":[29],"HCV-associated":[31],"neuropsychiatric":[32,55,69,80,195,241,265],"symptoms-depression,":[33],"anxiety,":[34,124,188,221],"fatigue,":[35,125,222],"pain.":[37,190,224],"An":[38],"additional":[39],"objective":[40],"factor":[48],"dysregulation":[49],"specific":[54],"symptoms":[56,70,266],"identify":[58],"biomarkers":[59,248],"that":[60,229],"may":[61],"be":[62],"relevant":[63],"treatment":[66],"these":[68],"adults":[72,88,116,268],"with":[73,112,135,186,264,269],"or":[74,270],"without":[75,271],"HCV.":[76,272],"MethodsBlood":[77],"samples":[78],"symptom":[81,196,242],"severity":[82,197],"scales":[83],"were":[84,130],"collected":[85],"from":[86],"HCV-infected":[87],"(HCV+,":[89],"n":[90,99],"=":[91,100],"39)":[92],"demographically":[94],"similar":[95],"noninfected":[96],"controls":[97],"(HCV-,":[98],"40).":[101],"Multi-analyte":[102],"profile":[103,139,173],"analysis":[104],"used":[106],"plasma":[109,145,207,236],"biomarkers.":[110],"ResultsCompared":[111],"HCV-":[113,168],"controls,":[114],"HCV+":[115,162],"reported":[117],"significantly":[118,143,184,199,212],"(P":[119],"<":[120],"0.050)":[121],"greater":[122],"depression,":[123,187,220],"pain,":[127],"they":[129],"more":[131],"likely":[132],"present":[134],"an":[136,170],"increased":[137,171],"as":[140],"indicated":[141],"by":[142,175,201],"higher":[144],"levels":[146],"40%":[148],"(19/47)":[149],"assessed":[153],"(21%,":[154],"after":[155],"correcting":[156],"for":[157,214],"multiple":[158],"comparisons).":[159],"Within":[160,191],"group,":[163,169],"but":[164],"not":[165],"within":[166],"(indicated":[174],"number":[177],">":[181],"LDC)":[183],"correlated":[185],"total":[193],"sample,":[194],"predicted":[200],"protein":[202,210],"signatures":[203,211],"consisting":[204],"4-10":[206],"factors;":[209],"accounted":[213],"19-40%":[215],"variance":[218],"ConclusionsOverall,":[225],"results":[227],"demonstrate":[228],"altered":[230],"a":[233],"network":[234],"contributes":[239],"severity.":[243],"These":[244],"findings":[245],"offer":[246],"new":[247],"potentially":[250],"facilitate":[251],"pharmacotherapeutic":[252],"development":[253],"increase":[256],"our":[257],"understanding":[258],"molecular":[261],"pathways":[262],"associated":[263]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
