{"id":"https://openalex.org/W1976817852","doi":"https://doi.org/10.1097/00007890-199709150-00008","title":"MODIFICATIONS OF THE CONDITIONING REGIMEN FOR ACHIEVING MIXED CHIMERISM AND DONOR-SPECIFIC TOLERANCE IN CYNOMOLGUS MONKEYS1","display_name":"MODIFICATIONS OF THE CONDITIONING REGIMEN FOR ACHIEVING MIXED CHIMERISM AND DONOR-SPECIFIC TOLERANCE IN CYNOMOLGUS MONKEYS1","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W1976817852","doi":"https://doi.org/10.1097/00007890-199709150-00008","mag":"1976817852","pmid":"https://pubmed.ncbi.nlm.nih.gov/9311707"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199709150-00008","doi":"https://doi.org/10.1097/00007890-199709150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199709150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020700086","display_name":"Masaaki Kimikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaaki Kimikawa","raw_affiliation_strings":["Transplantation Unit, Massachusetts General Hospital, Boston 02114, USA","Department of Surgery, Transplantation Unit, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Unit, Massachusetts General Hospital, Boston 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Surgery, Transplantation Unit, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073338357","display_name":"David H. Sachs","orcid":"https://orcid.org/0000-0001-9588-8580","observed_orcids":["https://orcid.org/0000-0001-9588-8580"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Sachs","raw_affiliation_strings":["Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019248592","display_name":"Robert B. Colvin","orcid":"https://orcid.org/0000-0002-4493-4150","observed_orcids":["https://orcid.org/0000-0002-4493-4150"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Colvin","raw_affiliation_strings":["Department of Pathology, Harvard Medical School","March 1997"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"March 1997","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112803953","display_name":"Amelia M. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia Bartholomew","raw_affiliation_strings":["Department of Surgery, Transplantation Unit, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Transplantation Unit, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009014767","display_name":"Tatsuo Kawai","orcid":"https://orcid.org/0000-0002-6900-4603","observed_orcids":["https://orcid.org/0000-0002-6900-4603"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Kawai","raw_affiliation_strings":["Department of Surgery, Tokyo Women's Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Women's Medical College","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000327969","display_name":"A. Benedict Cosimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Benedict Cosimi","raw_affiliation_strings":["A. Benedict Cosimi, MD, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114","Department of Surgery, Transplantation Unit, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. Benedict Cosimi, MD, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Surgery, Transplantation Unit, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000327969"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":15.716,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.99374864,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"5","first_page":"709","last_page":"716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.1931000053882599,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mixed-chimerism","display_name":"mixed chimerism","score":0.9490000009536743},{"id":"https://openalex.org/keywords/donor-specific-tolerance","display_name":"donor-specific tolerance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nonmyeloablative-conditioning","display_name":"nonmyeloablative conditioning","score":0.8410000205039978},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fractionated-irradiation","display_name":"fractionated irradiation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.7680000066757202},{"id":"https://openalex.org/keywords/donor-bone-marrow","display_name":"donor bone marrow","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ureteral-complications","display_name":"ureteral complications","score":0.7789999842643738},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.7445518970489502},{"id":"https://openalex.org/C2993801483","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Conditioning regimen","level":4,"score":0.6916505098342896},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.548199474811554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4885305166244507},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35838884115219116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2040863335132599},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.17558500170707703},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07116055488586426},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.047513484954833984},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.04627874493598938}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010198","descriptor_name":"Pancytopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018183","descriptor_name":"Transplantation Chimera","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018183","descriptor_name":"Transplantation Chimera","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019172","descriptor_name":"Transplantation Conditioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199709150-00008","doi":"https://doi.org/10.1097/00007890-199709150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199709150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:9311707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9311707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4652544260","display_name":null,"funder_award_id":"AI37692","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7179858646","display_name":"MIXED CHIMERISM AND TOLERANCE IN CYNOMOLGUS MONKEYS","funder_award_id":"R21AI037692","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W11344094","https://openalex.org/W113957853","https://openalex.org/W1653144806","https://openalex.org/W1978833480","https://openalex.org/W1979661472","https://openalex.org/W1983329640","https://openalex.org/W1990046941","https://openalex.org/W2001622972","https://openalex.org/W2019073639","https://openalex.org/W2028537846","https://openalex.org/W2036276239","https://openalex.org/W2150841203","https://openalex.org/W2198491966","https://openalex.org/W2397612706","https://openalex.org/W2416414471","https://openalex.org/W2418730570","https://openalex.org/W4205363739","https://openalex.org/W4402948460"],"related_works":["https://openalex.org/W1983329640","https://openalex.org/W1984220896","https://openalex.org/W1964139974","https://openalex.org/W2772768297","https://openalex.org/W2012923396","https://openalex.org/W3082917238","https://openalex.org/W1968241762","https://openalex.org/W2040301784","https://openalex.org/W2884088056","https://openalex.org/W1998484582"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"demonstrated":[2],"previously":[3],"that":[4],"a":[5,89,137],"nonmyeloablative":[6],"preparative":[7,194],"regimen":[8,38,195],"can":[9],"induce":[10],"mixed":[11],"chimerism":[12,72,85,98,147,224,244],"and":[13,29,99,157,178,241],"allograft":[14,75,162],"tolerance":[15],"in":[16,148,183,220,249],"cynomolgus":[17],"monkeys.":[18],"METHODS:":[19],"The":[20,92,203],"current":[21],"studies":[22],"were":[23],"designed":[24],"to":[25,146,172,175,197,210,234,246],"clarify":[26],"the":[27,35,43,158,184,192,211,236],"importance":[28],"toxicity":[30],"of":[31,34,78,88,105,112,118,127,140,154,161,168,191,205,225,239],"various":[32],"elements":[33],"allotolerance":[36],"conditioning":[37],"by:":[39],"fractionating":[40],"or":[41,50,57,67,73],"reducing":[42],"whole-body":[44],"irradiation":[45,68],"(WBI)":[46],"dosage;":[47],"adding":[48],"deoxyspergualine;":[49],"deleting":[51],"donor":[52,63],"bone":[53,64],"marrow,":[54,65],"cyclosporine,":[55,66],"irradiation,":[56],"splenectomy.":[58],"RESULTS:":[59],"Monkeys":[60],"treated":[61,81,108,130],"without":[62,82],"did":[69,95],"not":[70,96],"develop":[71,97],"long-term":[74,122,185],"survival.":[76,124],"One":[77],"three":[79],"monkeys":[80,107,129],"splenectomy":[83],"developed":[84,115,134],"but":[86,151],"died":[87,153,160],"surgical":[90],"complication.":[91],"other":[93,159],"two":[94,126,149],"rejected":[100],"by":[101],"day":[102],"117.":[103],"Six":[104],"six":[106],"with":[109,131],"300":[110],"cGy":[111,133],"fractionated":[113],"WBI":[114,212],"chimerism.":[116],"Five":[117],"these":[119],"recipients":[120,221],"had":[121],"graft":[123,215],"Only":[125],"four":[128],"250":[132],"chimerism,":[135,240],"so":[136],"2-week":[138],"course":[139],"deoxyspergualine":[141],"was":[142,181,208,217],"added.":[143],"This":[144],"led":[145],"monkeys,":[150],"one":[152],"ureteral":[155,169],"stenosis":[156],"rejection.":[163],"An":[164],"unanticipated":[165],"high":[166],"incidence":[167],"complications":[170],"felt":[171],"be":[173,198,235,247],"secondary":[174],"rejection":[176],"episodes":[177],"ischemic":[179],"injury":[180],"observed":[182,218],"surviving":[186],"animals.":[187],"CONCLUSIONS:":[188],"All":[189],"parameters":[190],"original":[193],"seem":[196],"essential":[199],"for":[200],"consistent":[201],"success.":[202],"degree":[204],"lymphocyte":[206,223,231,243],"depletion":[207,232],"proportional":[209],"dose.":[213],"Long-term":[214],"survival":[216],"only":[219],"achieving":[222,250],">":[226],"1.5%.":[227],"In":[228],"this":[229],"model,":[230],"seems":[233,245],"best":[237],"predictor":[238],"significant":[242],"important":[248],"tolerance.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}