{"id":"https://openalex.org/W1976796872","doi":"https://doi.org/10.1017/s0007114512000177","title":"Immune status is more affected by age than by carotenoid depletion\u2013repletion in healthy human subjects","display_name":"Immune status is more affected by age than by carotenoid depletion\u2013repletion in healthy human subjects","publication_year":2012,"publication_date":"2012-03-08","ids":{"openalex":"https://openalex.org/W1976796872","doi":"https://doi.org/10.1017/s0007114512000177","mag":"1976796872","pmid":"https://pubmed.ncbi.nlm.nih.gov/22397808"},"language":"en","primary_location":{"id":"doi:10.1017/s0007114512000177","doi":"https://doi.org/10.1017/s0007114512000177","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114512000177","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5D694A3EFFA45A8D7710805C842E8CAC/S0007114512000177a.pdf/div-class-title-immune-status-is-more-affected-by-age-than-by-carotenoid-depletion-repletion-in-healthy-human-subjects-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5D694A3EFFA45A8D7710805C842E8CAC/S0007114512000177a.pdf/div-class-title-immune-status-is-more-affected-by-age-than-by-carotenoid-depletion-repletion-in-healthy-human-subjects-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107232727","display_name":"Marie\u2010Chantal Farges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Chantal Farges","raw_affiliation_strings":["Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000              Clermont-Ferrand, France","Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000              Clermont-Ferrand, France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210137075","https://openalex.org/I4405259134"]},{"raw_affiliation_string":"Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081408904","display_name":"R\u00e9gine Minet\u2010Quinard","orcid":"https://orcid.org/0000-0002-3426-3955","observed_orcids":["https://orcid.org/0000-0002-3426-3955"]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9gine Minet-Quinard","raw_affiliation_strings":["Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210137075","https://openalex.org/I4405259134"]},{"raw_affiliation_string":"Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085545074","display_name":"St\u00e9phane Walrand","orcid":"https://orcid.org/0000-0002-4349-3664","observed_orcids":["https://orcid.org/0000-0002-4349-3664"]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Walrand","raw_affiliation_strings":["Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210137075","https://openalex.org/I4405259134"]},{"raw_affiliation_string":"Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030329962","display_name":"\u00c9milie Thivat","orcid":"https://orcid.org/0000-0001-6833-1971","observed_orcids":["https://orcid.org/0000-0001-6833-1971"]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Thivat","raw_affiliation_strings":["Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210137075","https://openalex.org/I4405259134"]},{"raw_affiliation_string":"Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085251638","display_name":"Josep Ribalta","orcid":"https://orcid.org/0000-0002-8879-4719","observed_orcids":["https://orcid.org/0000-0002-8879-4719"]},"institutions":[{"id":"https://openalex.org/I55952717","display_name":"Universitat Rovira i Virgili","ror":"https://ror.org/00g5sqv46","country_code":"ES","type":"education","lineage":["https://openalex.org/I55952717"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Ribalta","raw_affiliation_strings":["Universitat Rovira i Virgili, Unitat de Recerca de Lipids i Arteriosclerosi, Reus, Spain","Universitat Rovira i Virgili"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat Rovira i Virgili, Unitat de Recerca de Lipids i Arteriosclerosi, Reus, Spain","institution_ids":["https://openalex.org/I55952717"]},{"raw_affiliation_string":"Universitat Rovira i Virgili","institution_ids":["https://openalex.org/I55952717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228349","display_name":"Brigitte M. Winklhofer\u2010Roob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Brigitte Winklhofer-Roob","raw_affiliation_strings":["Human Nutrition and Metabolism Research and Training Center (HNMRC), Institute of Molecular Biosciences, Karl-Franzens University, Institute of Molecular Biology, Biochemistry and Microbiology, Graz, Austria","Karl-Franzens-Universit\u00e4t Graz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition and Metabolism Research and Training Center (HNMRC), Institute of Molecular Biosciences, Karl-Franzens University, Institute of Molecular Biology, Biochemistry and Microbiology, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]},{"raw_affiliation_string":"Karl-Franzens-Universit\u00e4t Graz","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111667753","display_name":"Edmond Rock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086514","display_name":"Unit\u00e9 de Nutrition Humaine","ror":"https://ror.org/003qhrc72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I198244214","https://openalex.org/I4210086514","https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edmond Rock","raw_affiliation_strings":["INRA, Unit\u00e9 des Maladies M\u00e9taboliques et des Micronutriments (UMMM), CRNH Auvergne, F-63122Saint-Gen\u00e8s-Champanelle, France","Unit\u00e9 de Nutrition Humaine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, Unit\u00e9 des Maladies M\u00e9taboliques et des Micronutriments (UMMM), CRNH Auvergne, F-63122Saint-Gen\u00e8s-Champanelle, France","institution_ids":["https://openalex.org/I4210137075"]},{"raw_affiliation_string":"Unit\u00e9 de Nutrition Humaine","institution_ids":["https://openalex.org/I4210086514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059434809","display_name":"Marie\u2010Paule Vasson","orcid":"https://orcid.org/0000-0001-8372-866X","observed_orcids":["https://orcid.org/0000-0001-8372-866X"]},"institutions":[{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]},{"id":"https://openalex.org/I4210137075","display_name":"Centre de Recherche en Nutrition Humaine d'Auvergne","ror":"https://ror.org/03rzyjb72","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210088668","https://openalex.org/I4210128870","https://openalex.org/I4210137075"]},{"id":"https://openalex.org/I4405259134","display_name":"Universit\u00e9 de Clermont I","ror":"https://ror.org/01stqnn06","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4405259134"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie-Paule Vasson","raw_affiliation_strings":["Centre Jean Perrin, Service de Nutrition, F-63000Clermont-Ferrand, France","Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","Centre Jean Perrin [Clermont-Ferrand]","Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Service de Nutrition, F-63000Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210124119"]},{"raw_affiliation_string":"Clermont Universit\u00e9, Universit\u00e9 d'Auvergne, EA 4233, LB2MN, CRNH Auvergne, BP 10448, F-63000Clermont-Ferrand, France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210137075","https://openalex.org/I4405259134"]},{"raw_affiliation_string":"Centre Jean Perrin [Clermont-Ferrand]","institution_ids":["https://openalex.org/I4210124119"]},{"raw_affiliation_string":"Nutrition, Canc\u00e9rogen\u00e8se et Th\u00e9rapie anti-tumorale","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5059434809"],"corresponding_institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210124119","https://openalex.org/I4210137075","https://openalex.org/I4405259134"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.4113,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75772386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"108","issue":"11","first_page":"2054","last_page":"2065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6294000148773193,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.1688999980688095,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9330000281333923},{"id":"https://openalex.org/keywords/age-related-immune-decline","display_name":"age-related immune decline","score":0.8539999723434448},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8029999732971191},{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lutein","display_name":"lutein","score":1.0},{"id":"https://openalex.org/keywords/serum-iga","display_name":"serum IgA","score":0.875},{"id":"https://openalex.org/keywords/t-helper-cell-subsets","display_name":"T helper cell subsets","score":0.6800000071525574},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neutrophil-bactericidal-activity","display_name":"neutrophil bactericidal activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immune-status","display_name":"immune status","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.826501727104187},{"id":"https://openalex.org/C2780050583","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohaemagglutinin","level":3,"score":0.8110347986221313},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.7402089834213257},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.6332638263702393},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5749271512031555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5574138164520264},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5349311828613281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529680609703064},{"id":"https://openalex.org/C2778411929","wikidata":"https://www.wikidata.org/wiki/Q422067","display_name":"Lutein","level":3,"score":0.44579458236694336},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.438196063041687},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43125224113464355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34218740463256836},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3227364718914032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2962334156036377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08708769083023071}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010585","descriptor_name":"Phagocyte Bactericidal Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010585","descriptor_name":"Phagocyte Bactericidal Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014802","descriptor_name":"Vitamin A Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017098","descriptor_name":"IgA Deficiency","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D017098","descriptor_name":"IgA Deficiency","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1017/s0007114512000177","doi":"https://doi.org/10.1017/s0007114512000177","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114512000177","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5D694A3EFFA45A8D7710805C842E8CAC/S0007114512000177a.pdf/div-class-title-immune-status-is-more-affected-by-age-than-by-carotenoid-depletion-repletion-in-healthy-human-subjects-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},{"id":"pmid:22397808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22397808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of nutrition","raw_type":"Clinical Trial"},{"id":"pmh:oai:HAL:hal-02650912v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02650912","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Nutrition, 2012, 108 (11), pp.2054 - 2065. ⟨10.1017/S0007114512000177⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:urv.cat:PC:263","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11797/PC263","pdf_url":null,"source":{"id":"https://openalex.org/S7407055111","display_name":"Rovira & Virgili repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10.1017/S0007114512000177","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1017/s0007114512000177","doi":"https://doi.org/10.1017/s0007114512000177","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114512000177","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5D694A3EFFA45A8D7710805C842E8CAC/S0007114512000177a.pdf/div-class-title-immune-status-is-more-affected-by-age-than-by-carotenoid-depletion-repletion-in-healthy-human-subjects-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976796872.pdf","grobid_xml":"https://content.openalex.org/works/W1976796872.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1522561762","https://openalex.org/W1867192595","https://openalex.org/W1910857921","https://openalex.org/W1937294600","https://openalex.org/W1945853733","https://openalex.org/W1955646182","https://openalex.org/W1970688989","https://openalex.org/W1981188847","https://openalex.org/W1986378808","https://openalex.org/W1995399390","https://openalex.org/W1998219025","https://openalex.org/W2005904344","https://openalex.org/W2019006994","https://openalex.org/W2024809782","https://openalex.org/W2029360775","https://openalex.org/W2032865807","https://openalex.org/W2037412303","https://openalex.org/W2039654885","https://openalex.org/W2040534704","https://openalex.org/W2047284046","https://openalex.org/W2055116911","https://openalex.org/W2064397740","https://openalex.org/W2066195719","https://openalex.org/W2076939693","https://openalex.org/W2082666025","https://openalex.org/W2083409755","https://openalex.org/W2088546805","https://openalex.org/W2100834013","https://openalex.org/W2106962073","https://openalex.org/W2106985608","https://openalex.org/W2107681355","https://openalex.org/W2113078618","https://openalex.org/W2122266437","https://openalex.org/W2133608246","https://openalex.org/W2137622145","https://openalex.org/W2141457548","https://openalex.org/W2147235488","https://openalex.org/W2148814667","https://openalex.org/W2150348160","https://openalex.org/W2162794606","https://openalex.org/W2188823020","https://openalex.org/W2237007259","https://openalex.org/W2295541768","https://openalex.org/W2419267367","https://openalex.org/W4211026086","https://openalex.org/W6808346460"],"related_works":["https://openalex.org/W2004146431","https://openalex.org/W2062340981","https://openalex.org/W2069696676","https://openalex.org/W2148814667","https://openalex.org/W2019006994","https://openalex.org/W2091379201","https://openalex.org/W2398813246","https://openalex.org/W1999926080","https://openalex.org/W2064397740","https://openalex.org/W2117193024"],"abstract_inverted_index":{"Prospective":[0],"studies":[1],"have":[2,12],"indicated":[3,115],"an":[4,116],"age-related":[5,30,236],"impairment":[6],"of":[7,22,35,50,97,176],"the":[8,23,29,33,121,140,157,252],"immune":[9,17,98,237,253],"response.":[10],"Carotenoids":[11],"been":[13],"hypothesised":[14],"to":[15,27],"enhance":[16],"cell":[18,124,163],"function.":[19],"The":[20],"aim":[21],"present":[24],"study":[25,89],"was":[26,169,182,191,199],"describe":[28],"effects":[31],"and":[32,41,45,65,80,93,95,145,173,190,227],"impact":[34],"in":[36,120,131,139,149,212,230,251],"vivo":[37,162],"dietary":[38,224],"carotenoid":[39,194,225],"depletion":[40,92,226],"repletion":[42],"on":[43,201,207],"specific":[44],"non-specific":[46],"immunity.":[47],"A":[48,136],"total":[49],"ninety-eight":[51],"healthy":[52,213,233],"male":[53],"subjects":[54,215],"(aged":[55],"20-75":[56],"years)":[57,189],"received":[58],"a":[59,129,146,166,249],"carotenoid-depleted":[60],"diet":[61],"for":[62,70,156],"3":[63],"weeks":[64,72],"were":[66,86,100,108,152],"then":[67],"supplemented":[68],"daily":[69],"5":[71],"with":[73,111,118,128,185],"30":[74],"mg":[75,78,82],"\u03b2-carotene,":[76],"15":[77],"lycopene":[79],"9":[81],"lutein.":[83],"Blood":[84],"samples":[85],"collected":[87],"at":[88],"entry,":[90],"after":[91],"supplementation,":[94],"biomarkers":[96],"status":[99],"determined.":[101],"We":[102],"found":[103,200],"that":[104],"serum":[105],"IgA":[106],"levels":[107],"positively":[109],"correlated":[110],"ageing.":[112],"Lymphocyte":[113],"phenotyping":[114],"increase":[117,138],"age":[119,172,186,197,220],"memory":[122],"T-helper":[123,133],"subpopulation":[125,144],"(CD4\u207aCD45RO\u207a)":[126],"concomitantly":[127],"decrease":[130,148],"naive":[132],"cells":[134,143],"(CD4\u207aCD45RA\u207a).":[135],"significant":[137],"natural":[141],"killer":[142],"small":[147],"B":[150],"lymphocytes":[151],"also":[153],"observed,":[154],"especially":[155],"oldest":[158],"volunteers.":[159],"From":[160],"ex":[161],"function":[164],"exploration,":[165],"positive":[167],"correlation":[168],"observed":[170],"between":[171],"IL-2":[174],"production":[175],"phytohaemagglutinin-stimulated":[177],"lymphocytes.":[178],"Neutrophils'":[179],"bactericidal":[180],"activity":[181],"significantly":[183],"impaired":[184],"(from":[187],"50":[188,242],"modulated":[192],"by":[193,219,223],"status.":[195],"An":[196],"effect":[198],"neutrophils'":[202],"spontaneous":[203],"migration":[204],"but":[205],"not":[206],"directed":[208],"migration.":[209],"Immune":[210],"response":[211],"human":[214],"is":[216],"mostly":[217],"affected":[218],"rather":[221],"than":[222],"repletion.":[228],"Even":[229],"carefully":[231],"selected":[232],"volunteers,":[234],"some":[235],"changes":[238],"occur":[239],"predominantly":[240],"from":[241],"years":[243],"onwards.":[244],"This":[245],"immunosenescence":[246],"could":[247],"generate":[248],"loss":[250],"system":[254],"adjustment":[255],"capacity.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}