{"id":"https://openalex.org/W1976754036","doi":"https://doi.org/10.1210/me.2003-0439","title":"Zebrafish Serotonin-N-Acetyltransferase-2 Gene Regulation: Pineal-Restrictive Downstream Module Contains a Functional E-Box and Three Photoreceptor Conserved Elements","display_name":"Zebrafish Serotonin-N-Acetyltransferase-2 Gene Regulation: Pineal-Restrictive Downstream Module Contains a Functional E-Box and Three Photoreceptor Conserved Elements","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W1976754036","doi":"https://doi.org/10.1210/me.2003-0439","mag":"1976754036","pmid":"https://pubmed.ncbi.nlm.nih.gov/14988431"},"language":"en","primary_location":{"id":"doi:10.1210/me.2003-0439","doi":"https://doi.org/10.1210/me.2003-0439","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2003-0439","pdf_url":"https://academic.oup.com/mend/article-pdf/18/5/1210/8967904/mend1210.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/18/5/1210/8967904/mend1210.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027650124","display_name":"Lior Appelbaum","orcid":"https://orcid.org/0000-0002-9248-5919","observed_orcids":["https://orcid.org/0000-0002-9248-5919"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Appelbaum","raw_affiliation_strings":["Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Department of Zoology (L.A., Y.G.), George S. Wise Faculty of Life Sciences 52900, Tel Aviv University, Tel Aviv 69978, Israel","Faculty of Life Sciences (L.A.,), Bar-Ilan University, Ramat Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Zoology (L.A., Y.G.), George S. Wise Faculty of Life Sciences 52900, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Faculty of Life Sciences (L.A.,), Bar-Ilan University, Ramat Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024980308","display_name":"Reiko Toyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reiko Toyama","raw_affiliation_strings":["Laboratory of Molecular Genetics (R.T., I.B.D.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics (R.T., I.B.D.), Bethesda, Maryland 20892","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":["Laboratory of Molecular Genetics (R.T., I.B.D.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics (R.T., I.B.D.), Bethesda, Maryland 20892","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070313847","display_name":"David C. Klein","orcid":"https://orcid.org/0000-0002-1792-5806","observed_orcids":["https://orcid.org/0000-0002-1792-5806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Klein","raw_affiliation_strings":["Laboratory of Developmental Neurobiology (D.C.K.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Neurobiology (D.C.K.), Bethesda, Maryland 20892","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085950606","display_name":"Rub\u00e9n Baler","orcid":"https://orcid.org/0000-0002-0621-0346","observed_orcids":["https://orcid.org/0000-0002-0621-0346"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Baler","raw_affiliation_strings":["National Institute of Child Health and Human Development, and Unit on Temporal Gene Expression (R.B.), Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Child Health and Human Development, and Unit on Temporal Gene Expression (R.B.), Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003600382","display_name":"Yoav Gothilf","orcid":"https://orcid.org/0000-0002-6054-4128","observed_orcids":["https://orcid.org/0000-0002-6054-4128"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Yoav Gothilf","raw_affiliation_strings":["Department of Zoology (L.A., Y.G.), George S. Wise Faculty of Life Sciences 52900, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology (L.A., Y.G.), George S. Wise Faculty of Life Sciences 52900, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003600382"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":null,"apc_paid":null,"fwci":2.3219,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.87630522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"5","first_page":"1210","last_page":"1221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-n-acetyltransferase","display_name":"serotonin N-acetyltransferase","score":0.8619999885559082},{"id":"https://openalex.org/keywords/arylalkylamine-n-acetyltransferase","display_name":"arylalkylamine N-acetyltransferase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/melatonin-synthesis","display_name":"melatonin synthesis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/e-box","display_name":"E-box","score":0.8240000009536743},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.5210000276565552},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8470882177352905},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6778081655502319},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.5767852663993835},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5186080932617188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5118809938430786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4609445035457611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4558105170726776},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.3697437047958374},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25668424367904663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08144941926002502}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010870","descriptor_name":"Pineal Gland","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047068","descriptor_name":"Arylalkylamine N-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047068","descriptor_name":"Arylalkylamine N-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/me.2003-0439","doi":"https://doi.org/10.1210/me.2003-0439","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2003-0439","pdf_url":"https://academic.oup.com/mend/article-pdf/18/5/1210/8967904/mend1210.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:14988431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14988431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/me.2003-0439","doi":"https://doi.org/10.1210/me.2003-0439","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2003-0439","pdf_url":"https://academic.oup.com/mend/article-pdf/18/5/1210/8967904/mend1210.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320950","display_name":"United States-Israel Binational Science Foundation","ror":"https://ror.org/00j8z2m73"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976754036.pdf","grobid_xml":"https://content.openalex.org/works/W1976754036.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1490936260","https://openalex.org/W1556198965","https://openalex.org/W1597109281","https://openalex.org/W1624787547","https://openalex.org/W1767401051","https://openalex.org/W1938523556","https://openalex.org/W1965863612","https://openalex.org/W1972006521","https://openalex.org/W1973042776","https://openalex.org/W1977158268","https://openalex.org/W1978307572","https://openalex.org/W1978618066","https://openalex.org/W1985648059","https://openalex.org/W1987638303","https://openalex.org/W2000373131","https://openalex.org/W2004790444","https://openalex.org/W2015472998","https://openalex.org/W2015652128","https://openalex.org/W2027222274","https://openalex.org/W2036303851","https://openalex.org/W2040876541","https://openalex.org/W2042267627","https://openalex.org/W2053370182","https://openalex.org/W2066183013","https://openalex.org/W2067588115","https://openalex.org/W2070494672","https://openalex.org/W2072414883","https://openalex.org/W2084036960","https://openalex.org/W2086067859","https://openalex.org/W2091301671","https://openalex.org/W2092189684","https://openalex.org/W2115806895","https://openalex.org/W2120128952","https://openalex.org/W2131997132","https://openalex.org/W2133333740","https://openalex.org/W2166820580","https://openalex.org/W2170078281","https://openalex.org/W2172252517","https://openalex.org/W2205162546","https://openalex.org/W2346797488","https://openalex.org/W2406524179","https://openalex.org/W3197051897"],"related_works":["https://openalex.org/W2073821450","https://openalex.org/W2094480161","https://openalex.org/W2064398077","https://openalex.org/W2053370182","https://openalex.org/W7096425539","https://openalex.org/W4233296850","https://openalex.org/W2153914898","https://openalex.org/W7095640641","https://openalex.org/W2014134453","https://openalex.org/W2188609456"],"abstract_inverted_index":{"Pineal":[0],"function":[1,127,161],"is":[2,27,64,77,84,118,172],"defined":[3],"by":[4,66,174],"a":[5,85,104,151],"set":[6],"of":[7,24,44,57,92,108,113,122,135,139,162,170,178],"very":[8],"narrowly":[9],"expressed":[10],"genes":[11],"that":[12,62,144,167],"encode":[13],"proteins":[14,26],"required":[15],"for":[16,158],"photoperiodic":[17],"transduction":[18],"and":[19,81,111,150,181,188,193],"rhythmic":[20],"melatonin":[21,39],"secretion.":[22],"One":[23,76],"these":[25],"serotonin":[28],"N-acetyltransferase":[29],"(arylalkylamine":[30],"N-acetyltransferase,":[31],"AANAT),":[32],"which":[33],"controls":[34],"the":[35,45,78,82,93,125,131,140,159,175,179,182],"daily":[36],"rhythm":[37],"in":[38,52],"production.":[40],"Here,":[41],"pineal-specific":[42],"expression":[43,55,110],"zebrafish":[46],"aanat-2":[47],"(zfaanat-2)":[48],"was":[49],"studied":[50],"using":[51],"vivo":[53],"transient":[54],"analyses":[56,138],"promoter-reporter":[58],"constructs;":[59],"this":[60],"revealed":[61,143],"specificity":[63,169],"determined":[65,173],"two":[67],"regions":[68],"located":[69,88],"12":[70],"kb":[71,90],"away":[72],"from":[73],"each":[74],"other.":[75],"5'-flanking":[79],"region,":[80],"other":[83],"257-bp":[86],"sequence,":[87],"6":[89],"downstream":[91,100,189],"transcribed":[94],"region.":[95],"This":[96],"3'-sequence,":[97],"designated":[98],"pineal-restrictive":[99],"module":[101],"(PRDM),":[102],"has":[103],"dual":[105,160,176],"function:":[106],"enhancement":[107],"pineal":[109,168],"inhibition":[112],"extrapineal":[114],"expression.":[115],"The":[116],"former":[117],"an":[119],"autonomic":[120],"property":[121],"PRDM":[123,141,180],"whereas":[124],"later":[126],"requires":[128],"interaction":[129,183],"with":[130],"upstream":[132,185],"regulatory":[133,186],"region":[134,187],"zfaanat-2.":[136],"Functional":[137],"sequence":[142],"three":[145],"photoreceptor":[146,190],"conserved":[147,191],"elements":[148,192],"(TAATC)":[149],"single":[152],"perfect":[153],"E-box":[154,194],"(CACGTG)":[155],"are":[156],"crucial":[157],"PRDM.":[163],"These":[164],"results":[165],"indicate":[166],"zfaanat-2":[171],"functionality":[177],"between":[184],"element.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}