{"id":"https://openalex.org/W1976717554","doi":"https://doi.org/10.3389/fgene.2014.00317","title":"Epigenetic control of gene function in schistosomes: a source of therapeutic targets?","display_name":"Epigenetic control of gene function in schistosomes: a source of therapeutic targets?","publication_year":2014,"publication_date":"2014-09-10","ids":{"openalex":"https://openalex.org/W1976717554","doi":"https://doi.org/10.3389/fgene.2014.00317","mag":"1976717554","pmid":"https://pubmed.ncbi.nlm.nih.gov/25309576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4159997"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2014.00317","doi":"https://doi.org/10.3389/fgene.2014.00317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00317","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00317/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00317/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037186720","display_name":"Alejandro Cabezas\u2010Cruz","orcid":"https://orcid.org/0000-0002-8660-730X","observed_orcids":["https://orcid.org/0000-0002-8660-730X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alejandro Cabezas-Cruz","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210098529"]},{"raw_affiliation_string":"INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010022616","display_name":"Julien Lancelot","orcid":"https://orcid.org/0000-0002-1648-819X","observed_orcids":["https://orcid.org/0000-0002-1648-819X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Lancelot","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210098529"]},{"raw_affiliation_string":"INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080967466","display_name":"St\u00e9phanie Caby","orcid":"https://orcid.org/0000-0001-7212-0288","observed_orcids":["https://orcid.org/0000-0001-7212-0288"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Caby","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210098529"]},{"raw_affiliation_string":"INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048496084","display_name":"Guilherme Oliveira","orcid":"https://orcid.org/0000-0003-0054-3438","observed_orcids":["https://orcid.org/0000-0003-0054-3438"]},"institutions":[{"id":"https://openalex.org/I4210151028","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126","country_code":"BR","type":"facility","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210127675","https://openalex.org/I4210151028","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Oliveira","raw_affiliation_strings":["Genomics and Computational Biology Group, Funda\u00e7\u00e3o Oswaldo Cruz, Center for Excellence in Bioinformatics, Centro de Pesquisas Ren\u00e9 Rachou, National Institute of Science and Technology in Tropical Diseases Belo Horizonte, Brazil","National Institute of Science and Technology in Tropical Diseases (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Computational Biology Group, Funda\u00e7\u00e3o Oswaldo Cruz, Center for Excellence in Bioinformatics, Centro de Pesquisas Ren\u00e9 Rachou, National Institute of Science and Technology in Tropical Diseases Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"National Institute of Science and Technology in Tropical Diseases (Brazil)","institution_ids":["https://openalex.org/I4210151028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061931567","display_name":"Raymond John Pierce","orcid":"https://orcid.org/0000-0001-9820-8608","observed_orcids":["https://orcid.org/0000-0001-9820-8608"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Raymond J. Pierce","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1019 - Centre National de la Recherche Scientifique UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210098529"]},{"raw_affiliation_string":"INSERM - Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (101, rue de Tolbiac, 75013 Paris  - France)","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Lille Nord de France (COMUE) (COMUE Communaut\u00e9 d'universit\u00e9s et \u00e9tablissements Lille-Nord-de-France - \r\n- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d\u2019Ascq Cedex \r\n- (A succ\u00e9d\u00e9 au PRES Universit\u00e9 de Lille Nord de France) - France)","institution_ids":["https://openalex.org/I59807433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5061931567"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I4210098529","https://openalex.org/I59807433"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.5835,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.41219512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"317","first_page":"317","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.953000009059906},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9520000219345093},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9089999794960022},{"id":"https://openalex.org/keywords/histone-variants","display_name":"histone variants","score":0.984000027179718},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.878000020980835},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetic-inhibitors","display_name":"epigenetic inhibitors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.675000011920929},{"id":"https://openalex.org/keywords/schistosome-development","display_name":"schistosome development","score":0.8299999833106995},{"id":"https://openalex.org/keywords/differentiation","display_name":"differentiation","score":0.44999998807907104},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6269999742507935},{"id":"https://openalex.org/keywords/reproductive-function","display_name":"reproductive function","score":0.5699999928474426},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9276338815689087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8155075311660767},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6446759104728699},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6391956210136414},{"id":"https://openalex.org/C63016187","wikidata":"https://www.wikidata.org/wiki/Q17162664","display_name":"Epigenetic regulation of neurogenesis","level":5,"score":0.5394389033317566},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4837051033973694},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4699174463748932},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4582783877849579},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.4314873218536377},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4238012731075287},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4192364513874054},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41342395544052124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.408957302570343},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30913737416267395},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2969014644622803},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.16928759217262268}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3389/fgene.2014.00317","doi":"https://doi.org/10.3389/fgene.2014.00317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00317","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00317/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3161906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4159997","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25309576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25309576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4159997","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4159997/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02630213v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02630213","pdf_url":"https://hal.inrae.fr/hal-02630213v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, 2014, 5 (317)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2315360","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2315360","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:arca.fiocruz.br:icict/9805","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/9805","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:71ccf374a3d74eb5849b4e06b5f6cebd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/71ccf374a3d74eb5849b4e06b5f6cebd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 5 (2014)","raw_type":"article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/9805","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/9805","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3389/fgene.2014.00317","doi":"https://doi.org/10.3389/fgene.2014.00317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00317","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00317/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1690248604","display_name":null,"funder_award_id":"573839/2008-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1712903622","display_name":null,"funder_award_id":"573839/2008-5","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G1906217239","display_name":null,"funder_award_id":"309312/2012\u20134","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1922090316","display_name":"Anti-Parasitic Drug Discovery in Epigenetics","funder_award_id":"602080","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3003150400","display_name":null,"funder_award_id":"309312/2012-4","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G3566165748","display_name":"IDENTIFICA\u00c7\u00c3O DE NOVOS ALVOS PARA O COMBATE A ESQUISTOSSOMOSE","funder_award_id":"PPM-00439-10","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G3888874160","display_name":null,"funder_award_id":"070/13","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4407732016","display_name":"Schistosoma Epigenetics - Targets, Regulation, New Drugs","funder_award_id":"241865","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5467174871","display_name":null,"funder_award_id":"309312/2012-4","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G581965161","display_name":null,"funder_award_id":"2012-4","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320316137","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976717554.pdf","grobid_xml":"https://content.openalex.org/works/W1976717554.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1964248507","https://openalex.org/W1964296506","https://openalex.org/W1967438932","https://openalex.org/W1968475818","https://openalex.org/W1969561666","https://openalex.org/W1971315193","https://openalex.org/W1972846893","https://openalex.org/W1972924731","https://openalex.org/W1974520407","https://openalex.org/W1976675316","https://openalex.org/W1977241172","https://openalex.org/W1977281942","https://openalex.org/W1984589574","https://openalex.org/W1985802000","https://openalex.org/W1985970694","https://openalex.org/W1990011854","https://openalex.org/W1990174038","https://openalex.org/W1990636453","https://openalex.org/W1993176720","https://openalex.org/W1993356881","https://openalex.org/W2000750221","https://openalex.org/W2001704867","https://openalex.org/W2002698073","https://openalex.org/W2002759367","https://openalex.org/W2003872705","https://openalex.org/W2004380688","https://openalex.org/W2005311687","https://openalex.org/W2005491164","https://openalex.org/W2007139310","https://openalex.org/W2008001323","https://openalex.org/W2008169720","https://openalex.org/W2009121506","https://openalex.org/W2010510740","https://openalex.org/W2011221870","https://openalex.org/W2014573268","https://openalex.org/W2017394727","https://openalex.org/W2020043868","https://openalex.org/W2021710587","https://openalex.org/W2022371371","https://openalex.org/W2029683459","https://openalex.org/W2030712838","https://openalex.org/W2034093709","https://openalex.org/W2037201757","https://openalex.org/W2041535798","https://openalex.org/W2042327889","https://openalex.org/W2044448268","https://openalex.org/W2046797184","https://openalex.org/W2049312848","https://openalex.org/W2052214665","https://openalex.org/W2054550062","https://openalex.org/W2054621094","https://openalex.org/W2055423985","https://openalex.org/W2056673958","https://openalex.org/W2058962103","https://openalex.org/W2060333462","https://openalex.org/W2062921719","https://openalex.org/W2062927905","https://openalex.org/W2064138320","https://openalex.org/W2064959533","https://openalex.org/W2065225507","https://openalex.org/W2066800469","https://openalex.org/W2066835202","https://openalex.org/W2066852267","https://openalex.org/W2067050450","https://openalex.org/W2067454999","https://openalex.org/W2069724690","https://openalex.org/W2071751135","https://openalex.org/W2071931654","https://openalex.org/W2073399316","https://openalex.org/W2076333986","https://openalex.org/W2078616374","https://openalex.org/W2079911032","https://openalex.org/W2082946800","https://openalex.org/W2088511656","https://openalex.org/W2094097897","https://openalex.org/W2094169801","https://openalex.org/W2098345898","https://openalex.org/W2098356010","https://openalex.org/W2100739229","https://openalex.org/W2104954848","https://openalex.org/W2107506178","https://openalex.org/W2112351720","https://openalex.org/W2115593774","https://openalex.org/W2141344438","https://openalex.org/W2144193004","https://openalex.org/W2144720261","https://openalex.org/W2146739166","https://openalex.org/W2149499695","https://openalex.org/W2155958514","https://openalex.org/W2157495337","https://openalex.org/W2157916750","https://openalex.org/W2159016980","https://openalex.org/W2163169932","https://openalex.org/W2167055696","https://openalex.org/W2168494970","https://openalex.org/W2169880855","https://openalex.org/W2177715039","https://openalex.org/W2320983896","https://openalex.org/W2371681713","https://openalex.org/W2462357342","https://openalex.org/W2477997870","https://openalex.org/W4211071799","https://openalex.org/W4238545515","https://openalex.org/W6652986406"],"related_works":["https://openalex.org/W2554181630","https://openalex.org/W4206263519","https://openalex.org/W7139948669","https://openalex.org/W271993543","https://openalex.org/W3084796561","https://openalex.org/W2970598395","https://openalex.org/W2900793673","https://openalex.org/W2079911032","https://openalex.org/W6959995463","https://openalex.org/W4406352406"],"abstract_inverted_index":{"The":[0],"discovery":[1,166],"of":[2,6,14,23,65,99,129,146],"the":[3,21,38,66,76,85,92,111,126,144],"epigenetic":[4,39,89,97,147,159],"regulation":[5],"gene":[7],"expression":[8],"has":[9,107],"revolutionized":[10],"both":[11],"our":[12,135],"understanding":[13,64],"how":[15],"genomes":[16],"function":[17,128],"and":[18,30,138,153,167],"approaches":[19],"to":[20,173,180],"therapy":[22],"numerous":[24],"pathologies.":[25],"Schistosomes":[26],"are":[27,60],"metazoan":[28],"parasites":[29],"as":[31,104,178],"such":[32],"utilize":[33],"most,":[34],"if":[35],"not":[36,119],"all":[37],"mechanisms":[40,71,148],"in":[41,43,68,84,88,149],"play":[42,74],"their":[44,114],"vertebrate":[45],"hosts:":[46],"histone":[47,49],"variants,":[48],"tail":[50],"modifications,":[51],"non-coding":[52],"RNA":[53],"and,":[54],"perhaps,":[55],"DNA":[56],"methylation.":[57],"Moreover,":[58],"we":[59,133,140],"acquiring":[61],"an":[62],"increasing":[63],"ways":[67],"which":[69,158],"these":[70],"come":[72],"into":[73],"during":[75],"complex":[77],"schistosome":[78,150],"developmental":[79],"program.":[80],"In":[81],"turn,":[82],"interest":[83],"actors":[86,160],"involved":[87],"mechanisms,":[90],"particularly":[91],"enzymes":[93],"that":[94,113],"carry":[95],"out":[96],"modifications":[98],"histones":[100],"or":[101],"nucleic":[102],"acid,":[103],"therapeutic":[105],"targets":[106],"been":[108],"stimulated":[109],"by":[110],"finding":[112],"inhibitors":[115,177],"exert":[116],"profound":[117],"effects,":[118],"only":[120],"on":[121,125],"survival,":[122],"but":[123],"also":[124],"reproductive":[127],"Schistosoma":[130],"mansoni.":[131],"Here,":[132],"review":[134],"current":[136],"knowledge,":[137],"what":[139,168],"can":[141,161,170],"infer,":[142],"about":[143],"role":[145],"development,":[151],"differentiation":[152],"survival.":[154],"We":[155],"will":[156],"consider":[157],"be":[162,171],"targeted":[163],"for":[164],"drug":[165],"strategies":[169],"employed":[172],"develop":[174],"potent,":[175],"selective":[176],"drugs":[179],"cure":[181],"schistosomiasis.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}