{"id":"https://openalex.org/W1976707014","doi":"https://doi.org/10.1371/journal.pgen.1003052","title":"A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation","display_name":"A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W1976707014","doi":"https://doi.org/10.1371/journal.pgen.1003052","mag":"1976707014","pmid":"https://pubmed.ncbi.nlm.nih.gov/23144635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493456"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1003052","doi":"https://doi.org/10.1371/journal.pgen.1003052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003052","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003052&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003052&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011858291","display_name":"Jennifer Yamtich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yamtich","raw_affiliation_strings":["Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040277138","display_name":"Antonia A. Nemec","orcid":"https://orcid.org/0000-0001-6060-1666","observed_orcids":["https://orcid.org/0000-0001-6060-1666"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonia A. Nemec","raw_affiliation_strings":["Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America","Baylor College of Medicine, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Baylor College of Medicine, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079221194","display_name":"Agnes Keh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnes Keh","raw_affiliation_strings":["Baylor College of Medicine, United States of America","Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031828516","display_name":"Joann Balazs Sweasy","orcid":"https://orcid.org/0000-0002-4503-0284","observed_orcids":["https://orcid.org/0000-0002-4503-0284"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joann B. Sweasy","raw_affiliation_strings":["Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031828516"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.1839,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.87443071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"11","first_page":"e1003052","last_page":"e1003052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":0.953000009059906},{"id":"https://openalex.org/keywords/germline-single-nucleotide-polymorphisms","display_name":"germline single nucleotide polymorphisms","score":0.8870000243186951},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9570000171661377},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.875},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.996999979019165},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5989999771118164},{"id":"https://openalex.org/keywords/catalytic-rate","display_name":"catalytic rate","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8481255769729614},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5941256284713745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5847040414810181},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5743905901908875},{"id":"https://openalex.org/C2778462844","wikidata":"https://www.wikidata.org/wiki/Q18030641","display_name":"DNA polymerase beta","level":5,"score":0.5529230833053589},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5399158000946045},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5257833003997803},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5133535265922546},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4718365967273712},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46912431716918945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44218364357948303},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.41588959097862244},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3752562999725342},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3701704740524292},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1051669716835022}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053904","descriptor_name":"DNA Breaks, Single-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pgen.1003052","doi":"https://doi.org/10.1371/journal.pgen.1003052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003052","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003052&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2492616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3493456","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493456","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:23144635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23144635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:12236605d3c5468a9f7cd37693c4cec9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/12236605d3c5468a9f7cd37693c4cec9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 8, Iss 11, p e1003052 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/117524","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Germline_Polymorphism_of_DNA_Polymerase_Beta_Induces_Genomic_Instability_and_Cellular_Transformation__/117524","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1003052","doi":"https://doi.org/10.1371/journal.pgen.1003052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003052","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003052&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6018072046","display_name":null,"funder_award_id":"CA-129186","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6043695350","display_name":"Targeting Multiple DNA Repair Pathways to Increase Drug Sensitivity","funder_award_id":"F32CA156843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6708497028","display_name":"DNA Repair in Cancer Biology and Therapy","funder_award_id":"P01CA129186","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976707014.pdf","grobid_xml":"https://content.openalex.org/works/W1976707014.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1694758169","https://openalex.org/W1963962795","https://openalex.org/W1971602039","https://openalex.org/W1992538062","https://openalex.org/W1992774519","https://openalex.org/W1998804839","https://openalex.org/W2004326614","https://openalex.org/W2005289526","https://openalex.org/W2011817030","https://openalex.org/W2016721913","https://openalex.org/W2026830245","https://openalex.org/W2026871647","https://openalex.org/W2027128597","https://openalex.org/W2032061690","https://openalex.org/W2035591821","https://openalex.org/W2059149287","https://openalex.org/W2073403193","https://openalex.org/W2074838235","https://openalex.org/W2081061529","https://openalex.org/W2088668023","https://openalex.org/W2090594860","https://openalex.org/W2092036047","https://openalex.org/W2092454225","https://openalex.org/W2092692569","https://openalex.org/W2097997319","https://openalex.org/W2116796830","https://openalex.org/W2126928556","https://openalex.org/W2130233138","https://openalex.org/W2130240153","https://openalex.org/W2131910049","https://openalex.org/W2134259738","https://openalex.org/W2137773292","https://openalex.org/W2146470798","https://openalex.org/W2151590716","https://openalex.org/W2156613325","https://openalex.org/W2167423675"],"related_works":["https://openalex.org/W2009900712","https://openalex.org/W2237517337","https://openalex.org/W2292112018","https://openalex.org/W1970774923","https://openalex.org/W2334047819","https://openalex.org/W2116275804","https://openalex.org/W4285271279","https://openalex.org/W2968751001","https://openalex.org/W2167423675","https://openalex.org/W2092454225"],"abstract_inverted_index":{"Several":[0],"germline":[1,69,159],"single":[2],"nucleotide":[3],"polymorphisms":[4],"(SNPs)":[5],"have":[6],"been":[7],"identified":[8],"in":[9,39,73,85],"the":[10,30,34,48,51,62,67,123,157],"POLB":[11,31,68],"gene,":[12,32],"but":[13],"little":[14],"is":[15,33],"known":[16],"about":[17],"their":[18],"cellular":[19,97],"and":[20,88,96,116,129],"biochemical":[21,130],"impact.":[22],"DNA":[23,55,146],"Polymerase":[24],"\u03b2":[25,127],"(Pol":[26],"\u03b2),":[27],"encoded":[28],"by":[29],"main":[35],"gap-filling":[36],"polymerase":[37],"involved":[38],"base":[40],"excision":[41],"repair":[42],"(BER),":[43],"a":[44,78,137],"pathway":[45],"that":[46,64,133,153],"protects":[47],"genome":[49],"from":[50],"consequences":[52],"of":[53,66,82],"oxidative":[54],"damage.":[56],"In":[57],"this":[58,83,107],"study":[59],"we":[60],"tested":[61],"hypothesis":[63],"expression":[65],"coding":[70,108],"SNP":[71,84,109,121,160],"(rs3136797)":[72],"mammalian":[74],"cells":[75,90,105],"could":[76],"induce":[77],"cancerous":[79],"phenotype.":[80],"Expression":[81],"both":[86],"human":[87],"mouse":[89],"induced":[91],"double-strand":[92,117],"breaks,":[93],"chromosomal":[94],"aberrations,":[95],"transformation.":[98],"Following":[99],"treatment":[100],"with":[101],"an":[102,164],"alkylating":[103],"agent,":[104],"expressing":[106],"accumulated":[110],"BER":[111],"intermediate":[112],"substrates,":[113],"including":[114],"single-strand":[115],"breaks.":[118],"The":[119],"rs3136797":[120,158],"encodes":[122],"P242R":[124,134,144],"variant":[125],"Pol":[126],"protein":[128,135],"analysis":[131],"showed":[132],"had":[136],"slower":[138],"catalytic":[139],"rate":[140],"than":[141],"WT,":[142],"although":[143],"binds":[145],"similarly":[147],"to":[148],"WT.":[149],"Our":[150],"results":[151],"suggest":[152],"people":[154],"who":[155],"carry":[156],"may":[161],"be":[162],"at":[163],"increased":[165],"risk":[166],"for":[167],"cancer":[168],"susceptibility.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}