{"id":"https://openalex.org/W1976561940","doi":"https://doi.org/10.1097/00042737-200403000-00015","title":"Expression of Fas antigen in liver tissue of patients with chronic hepatitis B and C","display_name":"Expression of Fas antigen in liver tissue of patients with chronic hepatitis B and C","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W1976561940","doi":"https://doi.org/10.1097/00042737-200403000-00015","mag":"1976561940","pmid":"https://pubmed.ncbi.nlm.nih.gov/15195900"},"language":"en","primary_location":{"id":"doi:10.1097/00042737-200403000-00015","doi":"https://doi.org/10.1097/00042737-200403000-00015","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042737-200403000-00015","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065304806","display_name":"Murat \u00d6ks\u00fcz","orcid":"https://orcid.org/0000-0001-8409-7708","observed_orcids":["https://orcid.org/0000-0001-8409-7708"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Murat Oksuz","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Cukurova, Adana, Turkey. m_oksuz@hotmail.com","Division of Gastroenterology, Department of Internal Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Cukurova, Adana, Turkey. m_oksuz@hotmail.com","institution_ids":["https://openalex.org/I55931168"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020253748","display_name":"Hikmet Akk\u0131z","orcid":"https://orcid.org/0000-0001-9745-8875","observed_orcids":["https://orcid.org/0000-0001-9745-8875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hikmet Akkiz","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098541693","display_name":"Y Fatih Isiksal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Fatih Isiksal","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050256774","display_name":"G\u00fcl\u015fah Saydao\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G??lsah Saydaoglu","raw_affiliation_strings":["Department of Biostatistics, Faculty of Medicine, University of Cukurova, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Faculty of Medicine, University of Cukurova, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010441792","display_name":"Mehmet Sami Serin","orcid":"https://orcid.org/0000-0002-5113-5509","observed_orcids":["https://orcid.org/0000-0002-5113-5509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Serin","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062130051","display_name":"Fazilet Kayasel\u00e7uk","orcid":"https://orcid.org/0000-0002-1180-3840","observed_orcids":["https://orcid.org/0000-0002-1180-3840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fazilet Kayaselcuk","raw_affiliation_strings":["Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004607386","display_name":"Bahri Abayl\u0131","orcid":"https://orcid.org/0000-0001-5583-8642","observed_orcids":["https://orcid.org/0000-0001-5583-8642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bahri Abayli","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111443090","display_name":"\u0130lhan Tuncer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilhan Tuncer","raw_affiliation_strings":["Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065304806"],"corresponding_institution_ids":["https://openalex.org/I55931168"],"apc_list":null,"apc_paid":null,"fwci":0.983,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77658632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"3","first_page":"341","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.17599999904632568,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-antigen","display_name":"Fas antigen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":1.0},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.949999988079071},{"id":"https://openalex.org/keywords/piecemeal-necrosis","display_name":"piecemeal necrosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/periportal-inflammation","display_name":"periportal inflammation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.6399999856948853},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7638880014419556},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6936012506484985},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.6650161147117615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6302016377449036},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.6043936610221863},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5947225093841553},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5291721224784851},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5286600589752197},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.49237191677093506},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4758993089199066},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.440534383058548},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3108788728713989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2463173270225525},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.16601255536079407},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06882113218307495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00042737-200403000-00015","doi":"https://doi.org/10.1097/00042737-200403000-00015","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042737-200403000-00015","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology &amp; Hepatology","raw_type":"journal-article"},{"id":"pmid:15195900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15195900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130910183","https://openalex.org/W2008779414","https://openalex.org/W2471522850","https://openalex.org/W2432321714","https://openalex.org/W2368064542","https://openalex.org/W2055218840","https://openalex.org/W3029086819","https://openalex.org/W595591757","https://openalex.org/W2126244353","https://openalex.org/W2382622200"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Cells":[1],"infected":[2,82,254],"with":[3,83,90,99],"the":[4,23,30,47,53,56,111,115,127,139,143,167,185,201,209,245,251],"hepatitis":[5,63,85,92,101,232],"B":[6,64,86],"or":[7,65],"C":[8,102],"virus":[9],"can":[10],"be":[11],"eliminated":[12],"by":[13,18,44],"an":[14],"immune":[15],"response":[16],"mediated":[17],"cytotoxic":[19,33],"T":[20,34],"cells.":[21,255],"Recently,":[22],"Fas":[24,48,57,72,105,158,188,212,224,246],"Ligand":[25],"has":[26],"been":[27],"detected":[28,124,228],"on":[29],"surface":[31],"of":[32,55,117,145,187,203,211,240,253],"cells,":[35],"and":[36,59,87,103,119,148,175,184,206,208,248],"is":[37,242],"thought":[38],"to":[39,42,46,70,134,250],"induce":[40],"cells":[41,122],"apoptosis":[43,60,239],"adhering":[45],"antigen.":[49],"METHODS:":[50],"To":[51],"evaluate":[52],"role":[54],"antigen":[58,73,106,159,168,189,213,225,247],"in":[61,75,110,152,161,229],"chronic":[62,84,91,100],"C,":[66],"we":[67],"used":[68],"immunohistochemistry":[69],"study":[71],"expression":[74,190,214],"liver":[76],"samples":[77,96],"obtained":[78],"from":[79,97],"30":[80],"patients":[81,89,98,230],"32":[88],"C.":[93],"RESULTS:":[94],"In":[95],"B,":[104],"was":[107,177,195,226],"mainly":[108],"expressed":[109],"cytoplasm":[112],"(partly":[113],"at":[114,126],"membrane)":[116],"hepatocytes,":[118],"these":[120,182],"positive":[121,156,179,198],"were":[123,150,155,164],"especially":[125],"periportal":[128,146],"region":[129],"near":[130],"'piecemeal":[131],"necrosis'.":[132],"According":[133],"Knodell's":[135],"scoring":[136],"system":[137],"for":[138,157,166],"histological":[140],"activity":[141],"index,":[142],"scores":[144,183,202],"inflammation":[147,205],"necrosis":[149,207],"higher":[151],"cases":[153,162],"that":[154,163,238],"than":[160],"negative":[165],"(n":[169,215],"=":[170,192,216,219,222],"62,":[171,217],"P":[172,221],"<":[173],"0.001)":[174],"there":[176],"a":[178,197],"correlation":[180,199],"between":[181,200],"degree":[186,210],"(r":[191],"0.621).":[193],"There":[194],"also":[196],"intralobular":[204],"r":[218],"0.522,":[220],"0.001).":[223],"not":[227],"without":[231],"infection.":[233],"CONCLUSIONS:":[234],"These":[235],"findings":[236],"suggest":[237],"hepatocytes":[241],"induced":[243],"via":[244],"contributes":[249],"elimination":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}