{"id":"https://openalex.org/W1976520588","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","title":"Selection of radioimmunoconjugates for the therapy of well-established or micrometastatic colon carcinoma","display_name":"Selection of radioimmunoconjugates for the therapy of well-established or micrometastatic colon carcinoma","publication_year":1997,"publication_date":"1997-07-29","ids":{"openalex":"https://openalex.org/W1976520588","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","mag":"1976520588","pmid":"https://pubmed.ncbi.nlm.nih.gov/9247292"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970729%2972%3A3%3C477%3A%3AAID-IJC16%3E3.0.CO%3B2-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043569662","display_name":"Robert M. Sharkey","orcid":"https://orcid.org/0000-0003-1408-0905","observed_orcids":["https://orcid.org/0000-0003-1408-0905"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert M. Sharkey","raw_affiliation_strings":["Garden State Cancer Center, Belleville, NJ 07109, USA","Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, Belleville, NJ 07109, USA","institution_ids":[]},{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110227609","display_name":"Rosalyn D. Blumenthal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalyn D. Blumenthal","raw_affiliation_strings":["Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110265404","display_name":"Thomas M. Behr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Behr","raw_affiliation_strings":["Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112783991","display_name":"George Y. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101825","display_name":"Strang Cancer Prevention Institute","ror":"https://ror.org/01d7ffm04","country_code":"US","type":"education","lineage":["https://openalex.org/I4210101825"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Y. Wong","raw_affiliation_strings":["Strang Cancer Prevention Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strang Cancer Prevention Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210101825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032658673","display_name":"Lemuel Haywood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lemuel Haywood","raw_affiliation_strings":["Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110679552","display_name":"D. E. Forman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Forman","raw_affiliation_strings":["Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072370404","display_name":"Gary L. Griffiths","orcid":"https://orcid.org/0000-0002-6252-1309","observed_orcids":["https://orcid.org/0000-0002-6252-1309"]},"institutions":[{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Griffiths","raw_affiliation_strings":["Immunomedics, Inc., Morris Plains, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunomedics, Inc., Morris Plains, NJ, USA","institution_ids":["https://openalex.org/I4210126919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003890903","display_name":"David M. Goldenberg","orcid":"https://orcid.org/0000-0001-5539-421X","observed_orcids":["https://orcid.org/0000-0001-5539-421X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Goldenberg","raw_affiliation_strings":["Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garden State Cancer Center, 520 Belleville Ave., Belleville, NJ 07109, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043569662"],"corresponding_institution_ids":[],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":5.2602,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95436146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"72","issue":"3","first_page":"477","last_page":"485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/radionuclide-selection","display_name":"radionuclide selection","score":0.8420000076293945},{"id":"https://openalex.org/keywords/iodine-131","display_name":"iodine-131","score":0.9819999933242798},{"id":"https://openalex.org/keywords/yttrium-90","display_name":"yttrium-90","score":0.996999979019165},{"id":"https://openalex.org/keywords/rhenium-188","display_name":"rhenium-188","score":0.996999979019165},{"id":"https://openalex.org/keywords/antibody-fragments","display_name":"antibody fragments","score":0.6629999876022339},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8830000162124634},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antibody-biodistribution","display_name":"antibody biodistribution","score":0.4740000069141388},{"id":"https://openalex.org/keywords/tumor-retention","display_name":"tumor retention","score":0.3970000147819519},{"id":"https://openalex.org/keywords/radiation-dosimetry","display_name":"radiation dosimetry","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6074305772781372},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5336869955062866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5264873504638672},{"id":"https://openalex.org/C2991914351","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colon carcinoma","level":4,"score":0.49331942200660706},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.470232218503952},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4431687593460083},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35004767775535583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30804264545440674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22074803709983826},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15167221426963806},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0906931459903717}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012211","descriptor_name":"Rhenium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015021","descriptor_name":"Yttrium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970729%2972%3A3%3C477%3A%3AAID-IJC16%3E3.0.CO%3B2-9","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:9247292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9247292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","doi":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970729)72:3<477::aid-ijc16>3.3.co;2-4","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970729%2972%3A3%3C477%3A%3AAID-IJC16%3E3.0.CO%3B2-9","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1454065977","display_name":"MANAGEMENT OF CANCER WITH MONOCLONAL ANTIBODIES","funder_award_id":"P01CA054425","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4330179423","display_name":"RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY OF CANCER","funder_award_id":"R35CA039841","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7469140909","display_name":"IMPROVED SECOND ANTIBODY RADIOIMMUNOTHERAPY OF CANCER","funder_award_id":"R01CA037895","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976520588.pdf","grobid_xml":"https://content.openalex.org/works/W1976520588.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W368763015","https://openalex.org/W1480650142","https://openalex.org/W1552915608","https://openalex.org/W1573177191","https://openalex.org/W1580701167","https://openalex.org/W1608334591","https://openalex.org/W1836696977","https://openalex.org/W1931731730","https://openalex.org/W1940470585","https://openalex.org/W1973029769","https://openalex.org/W1974765288","https://openalex.org/W2011150674","https://openalex.org/W2025146800","https://openalex.org/W2030233509","https://openalex.org/W2031822911","https://openalex.org/W2046118059","https://openalex.org/W2048674261","https://openalex.org/W2056397944","https://openalex.org/W2072105586","https://openalex.org/W2084377890","https://openalex.org/W2084493022","https://openalex.org/W2088798179","https://openalex.org/W2093329885","https://openalex.org/W2097090958","https://openalex.org/W2101638553","https://openalex.org/W2108980544","https://openalex.org/W2119889573","https://openalex.org/W2128378956","https://openalex.org/W2134354949","https://openalex.org/W2140308459","https://openalex.org/W2143394985","https://openalex.org/W2151123287","https://openalex.org/W2287079750","https://openalex.org/W2398217679","https://openalex.org/W2409637188"],"related_works":["https://openalex.org/W1836696977","https://openalex.org/W1984893522","https://openalex.org/W2053355093","https://openalex.org/W1642037236","https://openalex.org/W2139641734","https://openalex.org/W2078538529","https://openalex.org/W2088798179","https://openalex.org/W2025146800","https://openalex.org/W2331792010","https://openalex.org/W2410525554"],"abstract_inverted_index":{"In":[0,209],"order":[1],"to":[2,13],"optimize":[3],"radioimmunotherapy":[4],"(RAIT)":[5],"as":[6],"a":[7,27,159,163,210],"cancer-treatment":[8],"modality,":[9],"it":[10],"is":[11,190,220],"necessary":[12],"select":[14],"the":[15,23,93,131,144,177,191,202,217,221,226,234],"appropriate":[16],"radionuclide":[17],"and":[18,43,47,58,62,72,102,121,136,140,143,151,230],"antibody":[19,34,134],"carrier.":[20],"We":[21],"evaluated":[22],"therapeutic":[24],"potential":[25],"of":[26,30,68,97,104,133,168,180,214,223,228,233],"single":[28],"cycle":[29],"Mu-9":[31,215],"anti-CSAp":[32],"monoclonal":[33],"(MAb)":[35],"labeled":[36],"with":[37,50,107,148],"3":[38],"different":[39,51,203],"radionuclides,":[40],"131I,":[41],"90Y":[42],"188Re.":[44],"Intact":[45],"antibodies":[46],"bivalent":[48],"fragments":[49],"blood":[52,115],"clearance":[53],"kinetics,":[54],"normal":[55,141],"organ":[56,207],"distribution":[57],"varying":[59],"tumor":[60,74,139,166,174],"accretion":[61,135],"retention":[63],"are":[64],"also":[65],"evaluated.":[66],"Efficacy":[67],"treatment":[69,212,227],"for":[70,195,225],"large":[71],"small":[73],"burden":[75],"was":[76,110,186],"assessed":[77],"in":[78,162,239],"nude":[79,240],"mice":[80],"bearing":[81],"s.c.":[82,229],"GW-39":[83,90,235],"human":[84,236],"colonic-carcinoma":[85,237],"xenografts":[86],"or":[87],"intrapulmonary":[88,231],"micrometastatic":[89],"colonies":[91],"at":[92],"maximal":[94],"tolerated":[95],"dose":[96],"each":[98,108],"agent.":[99],"The":[100],"magnitude":[101],"duration":[103],"myelosuppression":[105,189],"associated":[106],"radioantibody":[109],"considered":[111],"by":[112],"monitoring":[113],"peripheral":[114],"counts,":[116],"marrow":[117],"colony-forming":[118],"unit":[119],"activity":[120,150],"hematopoietic":[122],"tissue":[123],"weight.":[124],"Radiation-dose":[125],"estimates":[126],"were":[127,146],"calculated":[128],"based":[129],"on":[130],"kinetics":[132],"elimination":[137],"from":[138],"tissues,":[142],"results":[145],"correlated":[147],"tumoricidal":[149],"dose-limiting":[152,193],"toxicity":[153,194],"results.":[154],"These":[155],"studies,":[156],"therefore,":[157],"represent":[158],"detailed":[160],"analysis,":[161],"well-defined":[164],"experimental":[165],"system,":[167],"several":[169],"parameters":[170],"(antibody":[171],"form,":[172],"radioisotope,":[173],"size)":[175],"influencing":[176],"overall":[178],"outcome":[179],"RAIT":[181],"using":[182],"equitoxic":[183],"doses.":[184],"It":[185],"found":[187],"that":[188],"primary":[192],"all":[196],"radioantibodies":[197],"except":[198],"90Y-F(ab')2,":[199],"even":[200],"though":[201],"agents":[204],"showed":[205],"varied":[206],"distribution.":[208],"single-cycle":[211],"schedule":[213],"MAb,":[216],"131I-labeled":[218],"IgG":[219],"radioimmunoconjugate":[222],"choice":[224],"growth":[232],"xenograft":[238],"mice.":[241]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}