{"id":"https://openalex.org/W1976485192","doi":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","title":"IncreasedRB1 abnormalities in human primary prostate cancer following combined androgen blockade","display_name":"IncreasedRB1 abnormalities in human primary prostate cancer following combined androgen blockade","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1976485192","doi":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","mag":"1976485192","pmid":"https://pubmed.ncbi.nlm.nih.gov/9465946"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","doi":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010265482","display_name":"Philip C. Mack","orcid":"https://orcid.org/0000-0003-4750-3812","observed_orcids":["https://orcid.org/0000-0003-4750-3812"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip C. Mack","raw_affiliation_strings":["Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento 95817, USA","Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento 95817, USA","institution_ids":["https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956997","display_name":"Sung-Gil Chi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sung-Gil Chi","raw_affiliation_strings":["Department of Urology, University of California, Davis Cancer Center, Sacramento, California","Kyung Hee University","University of California at Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Davis Cancer Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Kyung Hee University","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"University of California at Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791022","display_name":"Frederick J. Meyers","orcid":"https://orcid.org/0000-0002-4456-4647","observed_orcids":["https://orcid.org/0000-0002-4456-4647"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick J. Meyers","raw_affiliation_strings":["Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066965027","display_name":"SUSAN LEROY STEWART","orcid":"https://orcid.org/0000-0002-1593-440X","observed_orcids":["https://orcid.org/0000-0002-1593-440X"]},"institutions":[{"id":"https://openalex.org/I1321488844","display_name":"Cancer Prevention Institute of California","ror":"https://ror.org/03bx60s49","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321488844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. Stewart","raw_affiliation_strings":["Northern California Cancer Center, Union City, California","Northern California Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern California Cancer Center, Union City, California","institution_ids":["https://openalex.org/I1321488844"]},{"raw_affiliation_string":"Northern California Cancer Center","institution_ids":["https://openalex.org/I1321488844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014023814","display_name":"Ralph Devere White","orcid":"https://orcid.org/0000-0002-2170-626X","observed_orcids":["https://orcid.org/0000-0002-2170-626X"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph W. deVere White","raw_affiliation_strings":["Department of Urology, University of California, Davis Cancer Center, Sacramento, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California, Davis Cancer Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021148471","display_name":"Paul H. Gumerlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul H. Gumerlock","raw_affiliation_strings":["Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California","University of California at Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Molecular Research Laboratory, Division of Hematology/Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California at Davis","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021148471"],"corresponding_institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4390039352","https://openalex.org/I84218800"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":1.9517,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84876596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"34","issue":"2","first_page":"145","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/combined-androgen-blockade","display_name":"combined androgen blockade","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hormone-withdrawal","display_name":"hormone withdrawal","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tumor-survival","display_name":"tumor survival","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7716538310050964},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.696991503238678},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6581787467002869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5520204305648804},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5046292543411255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4779898524284363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47064656019210815},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45272281765937805},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4438351094722748},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4205380082130432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41160184144973755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41070666909217834},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33283859491348267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3034322261810303},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2879205048084259},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08521851897239685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06667181849479675}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","doi":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0045(19980201)34:2<145::aid-pros10>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:9465946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9465946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1347758079","display_name":"MOLECULAR EXPRESSION ANALYSIS IN PROSTATE CANCER","funder_award_id":"U01CA057183","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1982869577","display_name":"QUANTITATIVE DNA MOLECULAR STUDIES IN PROSTATE CANCER","funder_award_id":"P01CA055792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W81266651","https://openalex.org/W1483323966","https://openalex.org/W1518721136","https://openalex.org/W1571930742","https://openalex.org/W1590842919","https://openalex.org/W1597645757","https://openalex.org/W1971245466","https://openalex.org/W1971874426","https://openalex.org/W1977442544","https://openalex.org/W1980890490","https://openalex.org/W1984557785","https://openalex.org/W2008681314","https://openalex.org/W2012293213","https://openalex.org/W2019187115","https://openalex.org/W2020729244","https://openalex.org/W2027558915","https://openalex.org/W2035066068","https://openalex.org/W2035159808","https://openalex.org/W2045553573","https://openalex.org/W2052878543","https://openalex.org/W2055162988","https://openalex.org/W2057477877","https://openalex.org/W2060725528","https://openalex.org/W2072320617","https://openalex.org/W2079601821","https://openalex.org/W2089218510","https://openalex.org/W2094249595","https://openalex.org/W2095573751","https://openalex.org/W2099985524","https://openalex.org/W2114473143","https://openalex.org/W2131155074","https://openalex.org/W2137330819","https://openalex.org/W2147355777","https://openalex.org/W2148875908","https://openalex.org/W2159652547","https://openalex.org/W2402217318","https://openalex.org/W2408884428","https://openalex.org/W2414621918","https://openalex.org/W2417791786","https://openalex.org/W2428071088"],"related_works":["https://openalex.org/W2094249595","https://openalex.org/W2416092915","https://openalex.org/W3101497623","https://openalex.org/W1993624611","https://openalex.org/W2062414325","https://openalex.org/W2125037952","https://openalex.org/W4414346983","https://openalex.org/W2095776712","https://openalex.org/W1989159834","https://openalex.org/W2936284926"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"RB1":[2,16,40,62,111,137,159],"proliferation":[3],"control":[4],"pathway":[5],"is":[6],"a":[7,20,106,117],"critical":[8],"determinant":[9],"of":[10,15,22,39,54,70,109,146,158,165],"cell":[11],"cycle":[12],"progression.":[13],"Abnormalities":[14],"are":[17],"found":[18,66,113,134],"in":[19,41,67,114],"variety":[21],"cancers,":[23],"and":[24],"the":[25,101,149],"association":[26],"with":[27,116],"human":[28],"prostate":[29],"cancer":[30],"(CaP)":[31],"was":[32,49,65,94,112,133],"examined":[33,44],"here.":[34],"METHODS:":[35],"RNA":[36,47],"expression":[37,53,64],"levels":[38],"CaPs":[42,71,87],"were":[43],"by":[45,51,144],"RT-PCR.":[46],"integrity":[48],"assessed":[50],"evaluating":[52],"an":[55],"endogenous":[56],"gene":[57],"standard.":[58],"RESULTS:":[59],"Abnormally":[60],"low":[61,90],"mRNA":[63],"12/33":[68],"(36%)":[69],"from":[72,103,148],"patients":[73],"who":[74],"had":[75],"received":[76],"combined":[77],"androgen":[78],"blockade":[79],"(CAB)":[80],"treatment.":[81],"In":[82,100,124],"contrast,":[83],"6/48":[84],"(13%)":[85],"untreated":[86,104,127],"showed":[88],"abnormally":[89],"expression.":[91],"This":[92],"difference":[93],"statistically":[95],"significant":[96],"(P":[97,121],"=":[98,122],"0.015).":[99],"samples":[102],"patients,":[105],"higher":[107,118],"frequency":[108],"abnormal":[110],"specimens":[115],"Gleason":[119],"grade":[120,130],"0.038).":[123],"addition,":[125],"one":[126],"stage":[128],"C,":[129],"9":[131],"specimen":[132],"to":[135,162],"express":[136],"transcripts":[138],"lacking":[139],"exon":[140],"22,":[141],"as":[142],"determined":[143],"sequencing":[145],"DNA":[147],"truncated":[150],"transcripts.":[151],"CONCLUSIONS:":[152],"These":[153],"findings":[154],"suggest":[155],"that":[156],"abnormalities":[157],"may":[160],"contribute":[161],"hormone-withdrawal-related":[163],"survival":[164],"CaP":[166],"cells.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}