{"id":"https://openalex.org/W1976480966","doi":"https://doi.org/10.1016/j.neures.2010.12.007","title":"Regulation and function of immediate-early genes in the brain: Beyond neuronal activity markers","display_name":"Regulation and function of immediate-early genes in the brain: Beyond neuronal activity markers","publication_year":2010,"publication_date":"2010-12-15","ids":{"openalex":"https://openalex.org/W1976480966","doi":"https://doi.org/10.1016/j.neures.2010.12.007","mag":"1976480966","pmid":"https://pubmed.ncbi.nlm.nih.gov/21163309"},"language":"en","primary_location":{"id":"doi:10.1016/j.neures.2010.12.007","doi":"https://doi.org/10.1016/j.neures.2010.12.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neures.2010.12.007","pdf_url":null,"source":{"id":"https://openalex.org/S8734658","display_name":"Neuroscience Research","issn_l":"0168-0102","issn":["0168-0102","1872-8111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101725781","display_name":"Hiroyuki Okuno","orcid":"https://orcid.org/0000-0001-6237-6503","observed_orcids":["https://orcid.org/0000-0001-6237-6503"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyuki Okuno","raw_affiliation_strings":["Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. okuno@m.u-tokyo.ac.jp","Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. okuno@m.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Neurochemistry, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101725781"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":2770,"currency":"USD","value_usd":2770},"apc_paid":null,"fwci":0.6355,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.54818653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"69","issue":"3","first_page":"175","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.20000000298023224,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":1.0},{"id":"https://openalex.org/keywords/arc-arg3-1","display_name":"Arc/Arg3.1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/long-term-memory-formation","display_name":"long-term memory formation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/de-novo-protein-synthesis","display_name":"de novo protein synthesis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6909999847412109},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.7513703107833862},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7510693073272705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6638847589492798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5980027318000793},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.563433051109314},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.558367908000946},{"id":"https://openalex.org/C2779555244","wikidata":"https://www.wikidata.org/wiki/Q409638","display_name":"Immediate early gene","level":4,"score":0.5040242075920105},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49439167976379395},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.43710559606552124},{"id":"https://openalex.org/C2993691153","wikidata":"https://www.wikidata.org/wiki/Q492","display_name":"Memory formation","level":3,"score":0.42014485597610474},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32526618242263794},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2799242436885834},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.24449566006660461},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22215566039085388},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10554605722427368},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017781","descriptor_name":"Genes, Immediate-Early","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neures.2010.12.007","doi":"https://doi.org/10.1016/j.neures.2010.12.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neures.2010.12.007","pdf_url":null,"source":{"id":"https://openalex.org/S8734658","display_name":"Neuroscience Research","issn_l":"0168-0102","issn":["0168-0102","1872-8111"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:21163309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21163309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5514509453","display_name":"Molecular basis of neuron-specific, activity-dependent regulation of the plasticity-related gene Arc","funder_award_id":"21500301","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":199,"referenced_works":["https://openalex.org/W43053486","https://openalex.org/W106933811","https://openalex.org/W1488313827","https://openalex.org/W1511386589","https://openalex.org/W1515372146","https://openalex.org/W1518755343","https://openalex.org/W1521766330","https://openalex.org/W1536589125","https://openalex.org/W1570674668","https://openalex.org/W1574327030","https://openalex.org/W1575531743","https://openalex.org/W1607671357","https://openalex.org/W1608785134","https://openalex.org/W1621681081","https://openalex.org/W1675950512","https://openalex.org/W1760280961","https://openalex.org/W1821092064","https://openalex.org/W1821495885","https://openalex.org/W1857015666","https://openalex.org/W1874620698","https://openalex.org/W1887007239","https://openalex.org/W1937327101","https://openalex.org/W1966761076","https://openalex.org/W1967888214","https://openalex.org/W1969507049","https://openalex.org/W1971851666","https://openalex.org/W1975572257","https://openalex.org/W1976245365","https://openalex.org/W1978659592","https://openalex.org/W1980319519","https://openalex.org/W1981675681","https://openalex.org/W1981730865","https://openalex.org/W1982465384","https://openalex.org/W1982889157","https://openalex.org/W1984332535","https://openalex.org/W1985584040","https://openalex.org/W1985629065","https://openalex.org/W1987460085","https://openalex.org/W1987615735","https://openalex.org/W1991498923","https://openalex.org/W1991660337","https://openalex.org/W1994611219","https://openalex.org/W1996068610","https://openalex.org/W1998145134","https://openalex.org/W2002637584","https://openalex.org/W2003102216","https://openalex.org/W2004107819","https://openalex.org/W2004784342","https://openalex.org/W2005744880","https://openalex.org/W2006159608","https://openalex.org/W2007157318","https://openalex.org/W2007653857","https://openalex.org/W2008424322","https://openalex.org/W2010653960","https://openalex.org/W2011389660","https://openalex.org/W2011882079","https://openalex.org/W2012639972","https://openalex.org/W2013185658","https://openalex.org/W2013719051","https://openalex.org/W2014787267","https://openalex.org/W2015772561","https://openalex.org/W2016721540","https://openalex.org/W2017587146","https://openalex.org/W2018081377","https://openalex.org/W2018112449","https://openalex.org/W2018662966","https://openalex.org/W2021168371","https://openalex.org/W2021253208","https://openalex.org/W2021885143","https://openalex.org/W2022814598","https://openalex.org/W2023395361","https://openalex.org/W2023549886","https://openalex.org/W2023686279","https://openalex.org/W2024126366","https://openalex.org/W2025247587","https://openalex.org/W2026432698","https://openalex.org/W2028175193","https://openalex.org/W2029252387","https://openalex.org/W2029446166","https://openalex.org/W2029687467","https://openalex.org/W2030040408","https://openalex.org/W2031177493","https://openalex.org/W2033026245","https://openalex.org/W2033195474","https://openalex.org/W2033529039","https://openalex.org/W2035830949","https://openalex.org/W2035857873","https://openalex.org/W2036224418","https://openalex.org/W2036960054","https://openalex.org/W2037685778","https://openalex.org/W2038068698","https://openalex.org/W2040124307","https://openalex.org/W2040673296","https://openalex.org/W2041045292","https://openalex.org/W2041915527","https://openalex.org/W2042651745","https://openalex.org/W2042749300","https://openalex.org/W2042834556","https://openalex.org/W2043254293","https://openalex.org/W2043782933","https://openalex.org/W2045738040","https://openalex.org/W2046909406","https://openalex.org/W2047809887","https://openalex.org/W2048146702","https://openalex.org/W2049134173","https://openalex.org/W2049511526","https://openalex.org/W2049900893","https://openalex.org/W2052410726","https://openalex.org/W2052747138","https://openalex.org/W2052782185","https://openalex.org/W2052977964","https://openalex.org/W2053544091","https://openalex.org/W2055852552","https://openalex.org/W2058601367","https://openalex.org/W2058861807","https://openalex.org/W2060645936","https://openalex.org/W2062904839","https://openalex.org/W2064751454","https://openalex.org/W2064751459","https://openalex.org/W2065432433","https://openalex.org/W2065870204","https://openalex.org/W2066679535","https://openalex.org/W2067823945","https://openalex.org/W2068105646","https://openalex.org/W2068412840","https://openalex.org/W2069469260","https://openalex.org/W2069605964","https://openalex.org/W2069652778","https://openalex.org/W2070019933","https://openalex.org/W2070191061","https://openalex.org/W2070250157","https://openalex.org/W2071140638","https://openalex.org/W2071140879","https://openalex.org/W2071148558","https://openalex.org/W2073145989","https://openalex.org/W2074073259","https://openalex.org/W2075009214","https://openalex.org/W2075293125","https://openalex.org/W2075377655","https://openalex.org/W2078128901","https://openalex.org/W2079194017","https://openalex.org/W2079472132","https://openalex.org/W2080428182","https://openalex.org/W2082235945","https://openalex.org/W2085710872","https://openalex.org/W2086045560","https://openalex.org/W2088359631","https://openalex.org/W2091558764","https://openalex.org/W2091845852","https://openalex.org/W2092669952","https://openalex.org/W2093612739","https://openalex.org/W2093723806","https://openalex.org/W2096397256","https://openalex.org/W2098553579","https://openalex.org/W2099814708","https://openalex.org/W2100699923","https://openalex.org/W2102973376","https://openalex.org/W2104221788","https://openalex.org/W2109807917","https://openalex.org/W2110906301","https://openalex.org/W2111920180","https://openalex.org/W2112642242","https://openalex.org/W2114559471","https://openalex.org/W2115394766","https://openalex.org/W2115736681","https://openalex.org/W2117421244","https://openalex.org/W2121198501","https://openalex.org/W2123002629","https://openalex.org/W2126772993","https://openalex.org/W2129237942","https://openalex.org/W2131370784","https://openalex.org/W2132708818","https://openalex.org/W2133083344","https://openalex.org/W2133850147","https://openalex.org/W2135214271","https://openalex.org/W2136827845","https://openalex.org/W2136972830","https://openalex.org/W2137385309","https://openalex.org/W2138435646","https://openalex.org/W2138473891","https://openalex.org/W2144186844","https://openalex.org/W2145183379","https://openalex.org/W2145905574","https://openalex.org/W2146205533","https://openalex.org/W2146460558","https://openalex.org/W2148389554","https://openalex.org/W2157468016","https://openalex.org/W2158332929","https://openalex.org/W2158521200","https://openalex.org/W2159508608","https://openalex.org/W2160769038","https://openalex.org/W2162272208","https://openalex.org/W2164515753","https://openalex.org/W2165818584","https://openalex.org/W2167194856","https://openalex.org/W2167423431","https://openalex.org/W2170974481","https://openalex.org/W2184203459","https://openalex.org/W2338205519"],"related_works":["https://openalex.org/W2224527671","https://openalex.org/W7135720760","https://openalex.org/W2085710872","https://openalex.org/W2162041348","https://openalex.org/W2141688992","https://openalex.org/W7098305165","https://openalex.org/W7095249020","https://openalex.org/W2082659217","https://openalex.org/W7096628369","https://openalex.org/W7096962414"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
