{"id":"https://openalex.org/W1976470813","doi":"https://doi.org/10.1016/j.chembiol.2009.12.010","title":"Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex","display_name":"Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1976470813","doi":"https://doi.org/10.1016/j.chembiol.2009.12.010","mag":"1976470813","pmid":"https://pubmed.ncbi.nlm.nih.gov/20142042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2819981"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2009.12.010","doi":"https://doi.org/10.1016/j.chembiol.2009.12.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2009.12.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552109004438/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S1074552109004438/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103567026","display_name":"Karen T. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen T. Smith","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO 64110, USA","Stowers Institute for Medical Research, Kansas City, MO 64110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110, USA","institution_ids":["https://openalex.org/I114131015"]},{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066752773","display_name":"Skylar Martin\u2010Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skylar A. Martin-Brown","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO 64110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079392980","display_name":"Laurence A. Florens","orcid":"https://orcid.org/0000-0002-9310-6650","observed_orcids":["https://orcid.org/0000-0002-9310-6650"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Florens","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO 64110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034566006","display_name":"Michael P. Washburn","orcid":"https://orcid.org/0000-0001-7568-2585","observed_orcids":["https://orcid.org/0000-0001-7568-2585"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Washburn","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160","Stowers Institute for Medical Research, Kansas City, MO 64110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059586165","display_name":"Jerry L. Workman","orcid":"https://orcid.org/0000-0001-8163-1952","observed_orcids":["https://orcid.org/0000-0001-8163-1952"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerry L. Workman","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO 64110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO 64110","institution_ids":["https://openalex.org/I114131015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059586165"],"corresponding_institution_ids":["https://openalex.org/I114131015"],"apc_list":null,"apc_paid":null,"fwci":3.5146,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93470695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"65","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ing2","display_name":"ING2","score":0.7519999742507935},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phd-finger","display_name":"PHD finger","score":0.746999979019165},{"id":"https://openalex.org/keywords/protein-complex-dissociation","display_name":"protein complex dissociation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/p21-promoter","display_name":"p21 promoter","score":0.9639999866485596},{"id":"https://openalex.org/keywords/zinc-chelation","display_name":"zinc chelation","score":0.765999972820282},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.8511767387390137},{"id":"https://openalex.org/C2776281265","wikidata":"https://www.wikidata.org/wiki/Q420327","display_name":"Hydroxamic acid","level":2,"score":0.7942219972610474},{"id":"https://openalex.org/C142354902","wikidata":"https://www.wikidata.org/wiki/Q18047334","display_name":"HDAC10","level":5,"score":0.6986116170883179},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.6856843829154968},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.6700179576873779},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5495626926422119},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.49814438819885254},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4891405403614044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4740407466888428},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4514344334602356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44297558069229126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4310934245586395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40024423599243164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33504483103752136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.326016366481781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1864403784275055},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.14160102605819702}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056264","descriptor_name":"Sin3 Histone Deacetylase and Corepressor Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.chembiol.2009.12.010","doi":"https://doi.org/10.1016/j.chembiol.2009.12.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2009.12.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552109004438/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},{"id":"pmid:20142042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20142042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2033370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2819981","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2819981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2819981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2009.12.010","doi":"https://doi.org/10.1016/j.chembiol.2009.12.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2009.12.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552109004438/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356914926","display_name":null,"funder_award_id":"F32 CA130468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2332258901","display_name":null,"funder_award_id":"5F32CA130468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3128423462","display_name":"Novel HDAC-interacting proteins that regulate breast cancer cell growth","funder_award_id":"1f32ca130468-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3623779153","display_name":null,"funder_award_id":"R37-GM-047867","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G42055176","display_name":"Mechanisms of Transcriptional Regulation in Chromatin","funder_award_id":"5r37gm047867-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5743304281","display_name":null,"funder_award_id":"GM047867","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976470813.pdf","grobid_xml":"https://content.openalex.org/works/W1976470813.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1587031596","https://openalex.org/W1820010991","https://openalex.org/W1968031432","https://openalex.org/W1978664410","https://openalex.org/W1989561482","https://openalex.org/W1991660464","https://openalex.org/W1993943756","https://openalex.org/W2000255462","https://openalex.org/W2001527591","https://openalex.org/W2004615717","https://openalex.org/W2009826707","https://openalex.org/W2011180717","https://openalex.org/W2013547494","https://openalex.org/W2017994198","https://openalex.org/W2019727148","https://openalex.org/W2022092223","https://openalex.org/W2023120014","https://openalex.org/W2024244901","https://openalex.org/W2027619236","https://openalex.org/W2028466043","https://openalex.org/W2029148944","https://openalex.org/W2032601646","https://openalex.org/W2033176001","https://openalex.org/W2034156554","https://openalex.org/W2035065476","https://openalex.org/W2036362283","https://openalex.org/W2056070148","https://openalex.org/W2062356134","https://openalex.org/W2063153428","https://openalex.org/W2064971912","https://openalex.org/W2068220184","https://openalex.org/W2071981322","https://openalex.org/W2073978750","https://openalex.org/W2078454854","https://openalex.org/W2087513381","https://openalex.org/W2099939399","https://openalex.org/W2105025183","https://openalex.org/W2113833115","https://openalex.org/W2130332831","https://openalex.org/W2135830745","https://openalex.org/W2149379768","https://openalex.org/W2149706478","https://openalex.org/W2152052588","https://openalex.org/W2156719499","https://openalex.org/W2167118090","https://openalex.org/W2168448928","https://openalex.org/W2198199336","https://openalex.org/W6675018125"],"related_works":["https://openalex.org/W111061145","https://openalex.org/W2147096811","https://openalex.org/W1567349619","https://openalex.org/W2582256585","https://openalex.org/W2321761736","https://openalex.org/W2522442018","https://openalex.org/W2069183879","https://openalex.org/W1971738816","https://openalex.org/W2052453190","https://openalex.org/W2049555579"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}