{"id":"https://openalex.org/W1976465462","doi":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","title":"Defense mechanisms in the mouth and their possible role in the prevention of dental caries: A review","display_name":"Defense mechanisms in the mouth and their possible role in the prevention of dental caries: A review","publication_year":1974,"publication_date":"1974-11-01","ids":{"openalex":"https://openalex.org/W1976465462","doi":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","mag":"1976465462","pmid":"https://pubmed.ncbi.nlm.nih.gov/4219219"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0714.1974.tb01721.x","doi":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110428266","display_name":"William H. Bowen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William H. Bowen","raw_affiliation_strings":["Caries Prevention and Research Branch, National Institute of Dental Research, Bethesda, Md., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caries Prevention and Research Branch, National Institute of Dental Research, Bethesda, Md., U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110428266"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.86,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.8534055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"6","first_page":"266","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-caries-prevention","display_name":"dental caries prevention","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lactoperoxidase","display_name":"lactoperoxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/salivary-immunoglobulins","display_name":"salivary immunoglobulins","score":0.9240000247955322},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.7630000114440918},{"id":"https://openalex.org/keywords/caries-vaccine","display_name":"caries vaccine","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.7824276685714722},{"id":"https://openalex.org/C201956729","wikidata":"https://www.wikidata.org/wiki/Q412728","display_name":"Lactoperoxidase","level":4,"score":0.7725217342376709},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.741693913936615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4773048162460327},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.4637395143508911},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4438796043395996},{"id":"https://openalex.org/C158689903","wikidata":"https://www.wikidata.org/wiki/Q450090","display_name":"Oral microbiology","level":3,"score":0.42232850193977356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4159584045410156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39032673835754395},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3718456029891968},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2534782588481903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08862572908401489},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.08362317085266113},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001433","descriptor_name":"Bacteriolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003733","descriptor_name":"Dental Caries Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0714.1974.tb01721.x","doi":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.1974.tb01721.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology &amp; Medicine","raw_type":"journal-article"},{"id":"pmid:4219219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4219219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oral pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W67136658","https://openalex.org/W77972939","https://openalex.org/W140153961","https://openalex.org/W305404681","https://openalex.org/W1526101614","https://openalex.org/W1543340876","https://openalex.org/W1588252833","https://openalex.org/W1649236586","https://openalex.org/W1832739760","https://openalex.org/W1898822015","https://openalex.org/W1952391452","https://openalex.org/W1963838711","https://openalex.org/W1964458517","https://openalex.org/W1971526772","https://openalex.org/W1977772456","https://openalex.org/W1983236196","https://openalex.org/W1983375612","https://openalex.org/W1984398433","https://openalex.org/W1987562997","https://openalex.org/W1988178158","https://openalex.org/W1991062167","https://openalex.org/W1993329221","https://openalex.org/W1994005864","https://openalex.org/W1997028367","https://openalex.org/W1997732867","https://openalex.org/W2000187654","https://openalex.org/W2007193248","https://openalex.org/W2007207817","https://openalex.org/W2013923321","https://openalex.org/W2014625011","https://openalex.org/W2017310572","https://openalex.org/W2020176163","https://openalex.org/W2020997458","https://openalex.org/W2025895050","https://openalex.org/W2026669552","https://openalex.org/W2030237466","https://openalex.org/W2033921714","https://openalex.org/W2037677574","https://openalex.org/W2039480105","https://openalex.org/W2047801369","https://openalex.org/W2048609584","https://openalex.org/W2052586849","https://openalex.org/W2061025234","https://openalex.org/W2068206348","https://openalex.org/W2071117695","https://openalex.org/W2077258691","https://openalex.org/W2078584920","https://openalex.org/W2078985145","https://openalex.org/W2086569200","https://openalex.org/W2092872574","https://openalex.org/W2093350722","https://openalex.org/W2100683586","https://openalex.org/W2119011467","https://openalex.org/W2132858471","https://openalex.org/W2133415327","https://openalex.org/W2161523807","https://openalex.org/W2314745226","https://openalex.org/W2316851015","https://openalex.org/W2318673228","https://openalex.org/W2334300375","https://openalex.org/W2338519972","https://openalex.org/W2411606403","https://openalex.org/W2412651405","https://openalex.org/W2425287247","https://openalex.org/W2436603461","https://openalex.org/W2438521249","https://openalex.org/W2763116825","https://openalex.org/W4313315516","https://openalex.org/W7074012178"],"related_works":["https://openalex.org/W177922333","https://openalex.org/W2433257757","https://openalex.org/W4400798619","https://openalex.org/W2117017850","https://openalex.org/W1963662245","https://openalex.org/W2417187056","https://openalex.org/W1991534803","https://openalex.org/W2789337012","https://openalex.org/W28845094","https://openalex.org/W2898903595"],"abstract_inverted_index":{"The":[0,50],"mouth":[1,22],"harbors":[2],"organisms":[3],"in":[4,20,32,47,56,79,92,99,119],"great":[5],"abundance;":[6],"yet":[7],"their":[8],"variety":[9],"is":[10,14,54],"limited":[11],"and":[12],"it":[13,88],"noteworthy":[15],"that":[16,94],"some":[17,35,53],"species":[18],"present":[19],"the":[21,33,41,44,48,57,75],"are":[23,28],"not":[24],"found":[25],"elsewhere.":[26],"There":[27],"many":[29],"antibacterial":[30],"substances":[31],"mouth,":[34],"of":[36,43,52,59,77,103],"which":[37],"may":[38],"contribute":[39],"to":[40,73,85,108],"control":[42],"microbial":[45],"flora":[46],"mouth.":[49],"activity":[51],"enhanced":[55],"presence":[58],"specific":[60],"antibody,":[61],"e.g.":[62,68],"lactoferrin,":[63],"although":[64],"others":[65],"appear":[66],"unaffected,":[67],"lactoperoxidase.":[69],"Opinions":[70],"differ":[71],"as":[72],"whether":[74],"level":[76],"immunoglobulins":[78],"human":[80],"saliva":[81],"can":[82,96],"be":[83,97,109,115],"related":[84],"caries.":[86],"Although":[87],"has":[89],"been":[90],"established":[91],"principle":[93],"caries":[95],"prevented":[98],"animals":[100],"by":[101],"means":[102],"vaccination,":[104],"substantial":[105],"work":[106],"remains":[107],"done":[110],"before":[111],"a":[112],"vaccine":[113],"will":[114],"available":[116],"for":[117],"testing":[118],"humans.":[120]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
