{"id":"https://openalex.org/W1976370896","doi":"https://doi.org/10.1055/s-2007-988513","title":"Daily consensus interferon versus peg-interferon alfa2b with weight based ribavirin in treatment-naive patients with chronic hepatitis C serotype-1","display_name":"Daily consensus interferon versus peg-interferon alfa2b with weight based ribavirin in treatment-naive patients with chronic hepatitis C serotype-1","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W1976370896","doi":"https://doi.org/10.1055/s-2007-988513","mag":"1976370896"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-988513","doi":"https://doi.org/10.1055/s-2007-988513","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-988513","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111611414","display_name":"Marcus Schuchmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Schuchmann","raw_affiliation_strings":["Uniklinik Mainz, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050098300","display_name":"H L\u00f6hr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H L\u00f6hr","raw_affiliation_strings":["Praxis f\u00fcr Gastroenterologie, Wiesbaden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Praxis f\u00fcr Gastroenterologie, Wiesbaden, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111226119","display_name":"R. Link","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Link","raw_affiliation_strings":["Klinikum, Offenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum, Offenburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079850830","display_name":"Peter Buggisch","orcid":"https://orcid.org/0000-0002-3076-3960","observed_orcids":["https://orcid.org/0000-0002-3076-3960"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Buggisch","raw_affiliation_strings":["Uniklinikum, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinikum, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069307755","display_name":"Michael A. Fuchs","orcid":"https://orcid.org/0000-0002-5557-682X","observed_orcids":["https://orcid.org/0000-0002-5557-682X"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Fuchs","raw_affiliation_strings":["Uniklinik, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064129630","display_name":"S Kaiser","orcid":"https://orcid.org/0000-0003-1667-1311","observed_orcids":["https://orcid.org/0000-0003-1667-1311"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Kaiser","raw_affiliation_strings":["Uniklinik, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044320481","display_name":"Christoph Antoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Antoni","raw_affiliation_strings":["Uniklinik, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, Mannheim, Germany","institution_ids":["https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567167","display_name":"T Witth\u00f6ft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Witth\u00f6ft","raw_affiliation_strings":["Uniklinik, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044805858","display_name":"JF Schlaak","orcid":"https://orcid.org/0000-0002-9499-1014","observed_orcids":["https://orcid.org/0000-0002-9499-1014"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Schlaak","raw_affiliation_strings":["Uniklinik, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069151214","display_name":"Peter R. Galle","orcid":"https://orcid.org/0000-0001-8294-0992","observed_orcids":["https://orcid.org/0000-0001-8294-0992","https://orcid.org/0000-0003-1967-0621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Galle","raw_affiliation_strings":["Uniklinik, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, Mainz, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109194967","display_name":"W. B\u00f6cher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W B\u00f6cher","raw_affiliation_strings":["Uniklinik, I. Med. Klinik, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniklinik, I. Med. Klinik, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2019,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61264024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/consensus-interferon","display_name":"consensus interferon","score":0.9829999804496765},{"id":"https://openalex.org/keywords/peginterferon-alfa-2b","display_name":"peginterferon alfa-2b","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9330000281333923},{"id":"https://openalex.org/keywords/end-of-treatment-response","display_name":"end of treatment response","score":0.8870000243186951},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.42100000381469727},{"id":"https://openalex.org/keywords/antiviral-therapy-comparison","display_name":"antiviral therapy comparison","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hcv-viral-load","display_name":"HCV RNA viral load","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9736723899841309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7339383363723755},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.681289553642273},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.669100284576416},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5514317154884338},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5163415670394897},{"id":"https://openalex.org/C2776461080","wikidata":"https://www.wikidata.org/wiki/Q7160835","display_name":"Pegylated interferon","level":5,"score":0.5019445419311523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4687511920928955},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4216950833797455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.340765118598938},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21655550599098206}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-988513","doi":"https://doi.org/10.1055/s-2007-988513","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-988513","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982155602","https://openalex.org/W2977531192","https://openalex.org/W2977423467","https://openalex.org/W2018394017","https://openalex.org/W2977461922","https://openalex.org/W2978991680","https://openalex.org/W2122136798","https://openalex.org/W7099944971","https://openalex.org/W2036281098","https://openalex.org/W2077729032"],"abstract_inverted_index":{"Introduction:":[0],"Consensus":[1],"interferon":[2,9],"(CIFN)":[3],"is":[4,36],"a":[5],"synthetic":[6],"type":[7],"1":[8],"with":[10,57,71,78,311],"enhanced":[11],"in":[12,212,261,272,287,294,302,308,346],"vitro":[13],"activity":[14],"compared":[15,37,242,349],"to":[16,38,86,243,331,350],"conventional":[17],"IFN-alfa":[18],"(IFNa).":[19],"In":[20],"the":[21,27,45,172,186,193,227,262,269,273,288,351],"prospective,":[22],"randomized":[23],"multicenter":[24],"PegIntron-Against-Consensus-Trial":[25],"(PACT),":[26],"efficacy":[28],"and":[29,34,184,196,223,239,250,279,292,296,300,304,315],"safety":[30],"of":[31,52,63,89,188,199,327],"daily":[32,318],"CIFN-treatment":[33],"ribavirin":[35],"PegInterferon":[39],"(PegIFN)":[40],"alfa2b":[41,65,329,338],"plus":[42,113,123,145,159],"ribavirin.":[43,74],"At":[44,192],"meeting,":[46],"we":[47],"will":[48,203],"present":[49],"final":[50],"results":[51],"all":[53,200],"291":[54,76],"patients":[55,77,181,202,310,348],"treated":[56],"an":[58],"induction":[59,93,126,341],"or":[60,66,147],"standard":[61,116,149,352],"regimen":[62,94,117,127,150],"PegIFN":[64,328,337],"consensus":[67],"interferon,":[68],"each":[69],"combined":[70],"weight":[72],"based":[73],"Methods:":[75],"chronic":[79,312],"HCV":[80,176],"serotype-1":[81,316],"infection":[82],"were":[83,169,208,257,285],"randomly":[84],"assigned":[85],"48":[87,120,153],"weeks":[88,98,107,121,131,140,154],"treatment":[90,183,218,229],"with:":[91],"PegIFNa2b":[92,115],"(group":[95,118,128,151],"A:":[96],"12":[97,130],"IFNa2b":[99],"10":[100],"->5":[101],"MU":[102],"qd,":[103,136],"followed":[104,137],"by":[105,138,171],"36":[106,139],"peg-IFNa2b":[108],"1,5":[109],"mcg/kg":[110],"x":[111],"week":[112],"ribavirin);":[114,124,146],"B:":[119],"Peg-IFNa2b":[122],"CIFN":[125,132,141,148,155,289,319,340],"C:":[129],"27":[133],"->18":[134],"mcg":[135,143,157],"9":[142,156],"qd":[144,158],"D:":[152],"ribavirin).":[160],"Follow":[161],"up":[162],"was":[163],"24":[164],"weeks.":[165],"Viral":[166],"response":[167,230,265],"rates":[168,232,267,284,324,345],"analysed":[170],"Roche":[173],"COBAS":[174],"Amplicor":[175],"Monitor":[177],"v2.0":[178],"test.":[179],"226":[180],"finished":[182],"represent":[185],"base":[187],"this":[189],"preliminary":[190],"analysis.":[191],"Meeting,":[194],"SVR":[195,323],"tolerability":[197],"data":[198],"randomised":[201],"be":[204],"presented.":[205],"Results:":[206],"There":[207],"no":[209,258],"significant":[210,259],"differences":[211,260],"patient":[213],"baseline":[214],"characteristics":[215],"between":[216,235,268],"both":[217],"groups":[219,236,244,271,290],"concerning":[220],"age,":[221],"gender":[222],"viral":[224],"load.":[225],"While":[226],"end-of":[228],"(ETR)":[231],"differed":[233],"significantly":[234],"A":[237],"(54%)":[238],"B":[240,303],"(61%)":[241],"C":[245,295,314],"(84%;":[246],"p<0,001":[247],"vs.":[248,254,298],"A)":[249],"D":[251,297],"(76%;":[252],"p<0,05":[253],"B),":[255],"there":[256],"sustained":[263],"virological":[264],"(SVR)":[266],"four":[270],"per-protocol":[274],"analysis":[275],"(44%,":[276],"44%,":[277],"49%":[278],"46%).":[280],"However,":[281],"drop":[282],"out":[283],"high":[286],"(39":[291],"28%":[293],"7":[299],"17%":[301],"C).":[305],"Conclusions:":[306],"Thus,":[307],"treatment-naive":[309],"hepatitis":[313],"infection,":[317],"could":[320],"not":[321],"increase":[322],"over":[325],"those":[326],"due":[330],"higher":[332],"relapse":[333],"rates.":[334],"Moreover,":[335],"neither":[336],"nor":[339],"therapy":[342],"increased":[343],"cure":[344],"these":[347],"regimen.":[353]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}