{"id":"https://openalex.org/W1976340441","doi":"https://doi.org/10.1504/ijlr.2006.007901","title":"Low-dose radiation induced modification of ROS and apoptosis in thymocytes of whole body irradiated mice","display_name":"Low-dose radiation induced modification of ROS and apoptosis in thymocytes of whole body irradiated mice","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W1976340441","doi":"https://doi.org/10.1504/ijlr.2006.007901","mag":"1976340441"},"language":"en","primary_location":{"id":"doi:10.1504/ijlr.2006.007901","doi":"https://doi.org/10.1504/ijlr.2006.007901","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijlr.2006.007901","pdf_url":null,"source":{"id":"https://openalex.org/S45151922","display_name":"International Journal of Low Radiation","issn_l":"1477-6545","issn":["1477-6545","1741-9190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Low Radiation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090488889","display_name":"Badri Narain Pandey","orcid":"https://orcid.org/0000-0001-6862-4424","observed_orcids":["https://orcid.org/0000-0001-6862-4424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.N. Pandey","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027895380","display_name":"Haladhar Dev Sarma","orcid":"https://orcid.org/0000-0001-7168-4487","observed_orcids":["https://orcid.org/0000-0001-7168-4487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.D. Sarma","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006543889","display_name":"Dhananjay Shukla","orcid":"https://orcid.org/0000-0001-9468-9897","observed_orcids":["https://orcid.org/0000-0001-9468-9897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Shukla","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078924442","display_name":"K.P. Mishra","orcid":"https://orcid.org/0000-0002-8371-3772","observed_orcids":["https://orcid.org/0000-0002-8371-3772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.P. Mishra","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6457,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.6918239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"2","issue":"1/2","first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.871999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":1.0},{"id":"https://openalex.org/keywords/thymic-lymphoma","display_name":"thymic lymphoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/radiation-induced-oxidative-stress","display_name":"radiation-induced oxidative stress","score":0.609000027179718},{"id":"https://openalex.org/keywords/gamma-radiation","display_name":"gamma radiation","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7827774882316589},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7515817284584045},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6236289739608765},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5318405628204346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4570787250995636},{"id":"https://openalex.org/C2910144714","wikidata":"https://www.wikidata.org/wiki/Q256348","display_name":"Low Dose Radiation","level":3,"score":0.4522058963775635},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44748860597610474},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.40912511944770813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31553763151168823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30503061413764954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1342378854751587},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijlr.2006.007901","doi":"https://doi.org/10.1504/ijlr.2006.007901","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijlr.2006.007901","pdf_url":null,"source":{"id":"https://openalex.org/S45151922","display_name":"International Journal of Low Radiation","issn_l":"1477-6545","issn":["1477-6545","1741-9190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Low Radiation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2348930114","https://openalex.org/W2057909542","https://openalex.org/W2389691136","https://openalex.org/W2284694529","https://openalex.org/W2120486291","https://openalex.org/W2111448548","https://openalex.org/W2374157510","https://openalex.org/W2364331577","https://openalex.org/W2170615816","https://openalex.org/W2009798707"],"abstract_inverted_index":{"Whole":[0],"body":[1,189],"irradiation":[2],"(WBI)":[3],"to":[4,20,42,58,129,146,177],"a":[5,49,76,111,130],"single":[6],"dose":[7,78,131,199,245],"of":[8,11,48,63,127,132,138,144,162,166,170,197,203,209,224,243],"3":[9,213],"Gy":[10,134],"\u03b3-rays":[12],"has":[13],"earlier":[14],"been":[15,56],"shown":[16,75],"in":[17,28,45,88,114,120,140,164,185,226,239,248],"our":[18],"laboratory":[19],"induce":[21],"thymic":[22],"lymphoma":[23],"(TL)":[24],"after":[25,125,142],"4-5":[26],"months":[27],"Swiss":[29],"mice.":[30,168],"The":[31],"tumour":[32,249],"induction":[33,161,184,250],"was":[34,118,151,158,175],"significantly":[35,178],"found":[36,153,176],"suppressed":[37],"when":[38],"animals":[39,171,204],"were":[40],"pre-exposed":[41],"radiation":[43,77,231],"doses":[44,208],"the":[46,60,241],"range":[47],"few":[50],"cGy.":[51],"Recent":[52],"research":[53],"efforts":[54],"have":[55,74,236],"focused":[57],"investigate":[59],"molecular":[61],"mechanism":[62,242],"these":[64],"observations.":[65],"In":[66],"vitro":[67],"studies":[68],"on":[69],"thymocytes":[70,121,165,186],"from":[71,187],"irradiated":[72,167,190],"mice":[73,128,193],"(1-5":[79],"Gy)":[80,84,192],"and":[81,100,116,182,216],"post-irradiation":[82],"(3":[83,191],"time":[85],"dependent":[86],"increase":[87,113],"intracellular":[89],"reactive":[90],"oxygen":[91],"species":[92],"(ROS)":[93],"as":[94,103],"measured":[95,104],"by":[96,105,251],"2,7-dichlorodihydroflurescein":[97],"diacetate":[98],"(DCH-FDA)":[99],"enhanced":[101],"apoptosis":[102,117,163,183],"fluorescent":[106],"probe,":[107],"merocyanine-540":[108],"(MC-540).":[109],"Typically,":[110],"five-fold":[112],"ROS":[115,139,157,180,225],"observed":[119],"collected":[122],"30":[123],"minutes":[124],"exposure":[126,143,202],"5":[133,217],"suggesting":[135,194,228],"substantial":[136],"up-regulation":[137],"cells":[141,227],"animal":[145],"moderate":[147],"oxidative":[148],"stress.":[149],"It":[150],"further":[152],"that":[154],"increased":[155],"cellular":[156],"correlated":[159],"with":[160,172,205],"Pre-exposure":[169],"1":[173,210,215,219],"cGy":[174,220],"inhibit":[179],"generation":[181],"whole":[188],"suppressive":[195],"effect":[196],"low":[198,207,244],"irradiation.":[200],"Moreover,":[201],"fractionated":[206],"\u00d7":[211,214,218],"1,":[212],"yielded":[221],"increasing":[222],"level":[223],"dose-dependent":[229],"accumulative":[230],"damage.":[232],"These":[233],"results":[234],"would":[235],"significant":[237],"implications":[238],"understanding":[240],"induced":[246],"suppression":[247],"radiation.":[252]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}