{"id":"https://openalex.org/W197630971","doi":null,"title":"[Late onset multiple sclerosis].","display_name":"[Late onset multiple sclerosis].","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W197630971","mag":"197630971","pmid":"https://pubmed.ncbi.nlm.nih.gov/12451340"},"language":"fr","primary_location":{"id":"pmid:12451340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12451340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue neurologique","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013376156","display_name":"Sophie Delalande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210101212","display_name":"H\u00f4pital Roger Salengro","ror":"https://ror.org/0165ax130","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210101212"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Delalande","raw_affiliation_strings":["Service de Neurologie D, H\u00f4pital Roger Salengro, CHRU Lille, 59037 Lille Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie D, H\u00f4pital Roger Salengro, CHRU Lille, 59037 Lille Cedex, France","institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210101212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011213325","display_name":"Jerome De Seze","orcid":"https://orcid.org/0000-0002-7197-7578","observed_orcids":["https://orcid.org/0000-0002-7197-7578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J De Seze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000858784","display_name":"Didier Ferriby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Ferriby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018913953","display_name":"Tanya Stojkovic","orcid":"https://orcid.org/0000-0002-4054-2838","observed_orcids":["https://orcid.org/0000-0002-4054-2838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Stojkovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025462803","display_name":"Patrick Vermersch","orcid":"https://orcid.org/0000-0003-0997-8817","observed_orcids":["https://orcid.org/0000-0003-0997-8817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Vermersch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0856,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.75370213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"158","issue":"11","first_page":"1082","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/late-onset-multiple-sclerosis","display_name":"late-onset multiple sclerosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.5830000042915344},{"id":"https://openalex.org/keywords/primary-progressive-multiple-sclerosis","display_name":"primary progressive multiple sclerosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/motor-symptoms","display_name":"motor symptoms","score":0.6740000247955322},{"id":"https://openalex.org/keywords/visual-evoked-potentials","display_name":"visual evoked potentials","score":0.828000009059906},{"id":"https://openalex.org/keywords/oligoclonal-bands","display_name":"oligoclonal bands","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8889999985694885},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.8209999799728394},{"id":"https://openalex.org/keywords/spinal-cord-mri","display_name":"spinal cord MRI","score":0.9599999785423279},{"id":"https://openalex.org/keywords/expanded-disability-status-scale","display_name":"Expanded Disability Status Scale","score":0.7979999780654907},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8029999732971191},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8747929334640503},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8232163190841675},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5708655118942261},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.537634551525116},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4309830367565155},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4241308271884918},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37385842204093933},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36989903450012207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3388003408908844},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005074","descriptor_name":"Evoked Potentials, Visual","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043025","descriptor_name":"Oligoclonal Bands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12451340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12451340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue neurologique","raw_type":"Comparative Study"},{"id":"mag:197630971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12451340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108499266","https://openalex.org/W2086661036","https://openalex.org/W2082957927","https://openalex.org/W2399259398","https://openalex.org/W4389464683","https://openalex.org/W1967468767","https://openalex.org/W2739464771","https://openalex.org/W2059926889","https://openalex.org/W4408578987","https://openalex.org/W4313680828"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"with":[3,92,170,251],"clinical":[4,43,70,87,197],"onset":[5,49,62,171,273],"after":[6,135,172],"50":[7,31,58,127],"years":[8,32,59,128,137,174],"old":[9,129,175],"is":[10],"unusual":[11],"and":[12,17,30,44,79,98,132,159,275,293],"frequently":[13,148],"misdiagnosed.":[14],"Clinical":[15],"presentation":[16,187],"course":[18],"seem":[19],"also":[20,85],"to":[21,40],"be":[22],"different":[23],"that":[24],"in":[25,215,236],"MS":[26,54,219,274],"occurring":[27],"between":[28,270],"20":[29],"old.":[33,138],"The":[34,204,232],"aim":[35],"of":[36,47,63,81,95,101,107,116,142,167,190,218,223,240,245,254,258,287],"this":[37,216],"study":[38,144,266,282],"was":[39,208],"evaluate":[41],"the":[42,61,64,90,93,99,102,105,140,143,168,183,202,246,252,268,271,284],"paraclinical":[45],"characteristics":[46],"late":[48,272],"MS.":[50,165,179,255],"We":[51,66,84],"respectively":[52],"studied":[53,86],"patients":[55,145,169,194,224,241,259],"older":[56,131],"than":[57],"at":[60,126],"disease.":[65],"evaluated":[67],"demographical":[68],"data,":[69],"symptoms,":[71],"cerebrospinal":[72],"fluid":[73],"(CSF),":[74],"visual":[75],"evoked":[76],"potentials":[77],"(VEPs)":[78],"MRI":[80,248,263],"these":[82],"patients.":[83,220],"data":[88],"during":[89,201],"follow-up":[91],"occurrence":[94],"new":[96],"symptoms":[97,125,181],"evolution":[100,214],"disease":[103],"by":[104,229],"index":[106,207],"progression":[108,206],"(EDSS":[109],"unit":[110],"per":[111],"year).":[112],"In":[113],"a":[114,149,155,162,196,211],"population":[115],"1":[117,209],"417":[118],"MS,":[119],"3.4":[120],"p.cent":[121,134,153,161,189,222,244,257],"had":[122,146,154,176,195,225,260],"their":[123],"first":[124],"or":[130],"0.45":[133],"59":[136],"At":[139],"time":[141],"more":[147],"progressive":[150,157,164,288],"form:":[151],"37":[152],"primary":[156],"form":[158],"35":[160],"secondary":[163],"None":[166],"60":[173,256],"relapsing":[177],"remittent":[178],"Motor":[180],"were":[182,234,249],"most":[184,212],"common":[185],"neurologic":[186],"(54":[188],"patients).":[191],"Very":[192],"few":[193],"optic":[198],"nerve":[199],"involvement":[200,292],"follow-up.":[203],"mean":[205],"suggesting":[210],"severe":[213],"subgroup":[217],"76":[221],"oligoclonal":[226],"banding":[227],"detected":[228],"CSF":[230],"electrophoresis.":[231],"VEPs":[233],"abnormal":[235],"81":[237],"p.":[238],"cent":[239],"tested.":[242],"71":[243],"brain":[247],"consistent":[250],"diagnosis":[253],"spinal":[261],"cord":[262],"abnormal.":[264],"This":[265],"highlights":[267],"differences":[269],"earlier":[276],"onset.":[277],"As":[278],"previously":[279],"reported,":[280],"our":[281],"underlines":[283],"high":[285],"frequency":[286],"course,":[289],"motor":[290],"function":[291],"poor":[294],"prognosis.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}