{"id":"https://openalex.org/W1976299665","doi":"https://doi.org/10.1016/j.metabol.2010.06.001","title":"Improvement of postprandial hyperglycemia and arterial stiffness upon switching from premixed human insulin 30/70 to biphasic insulin aspart 30/70","display_name":"Improvement of postprandial hyperglycemia and arterial stiffness upon switching from premixed human insulin 30/70 to biphasic insulin aspart 30/70","publication_year":2010,"publication_date":"2010-07-30","ids":{"openalex":"https://openalex.org/W1976299665","doi":"https://doi.org/10.1016/j.metabol.2010.06.001","mag":"1976299665","pmid":"https://pubmed.ncbi.nlm.nih.gov/20667560"},"language":"en","primary_location":{"id":"doi:10.1016/j.metabol.2010.06.001","doi":"https://doi.org/10.1016/j.metabol.2010.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.metabol.2010.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039591257","display_name":"Masahiro Ohira","orcid":"https://orcid.org/0000-0002-1935-6125","observed_orcids":["https://orcid.org/0000-0002-1935-6125"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Ohira","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090468734","display_name":"Kei Endo","orcid":"https://orcid.org/0000-0002-9698-2779","observed_orcids":["https://orcid.org/0000-0002-9698-2779"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Endo","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067143904","display_name":"Tomokazu Oyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomokazu Oyama","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102002375","display_name":"Takashi Yamaguchi","orcid":"https://orcid.org/0000-0003-0464-4674","observed_orcids":["https://orcid.org/0000-0003-0464-4674"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Yamaguchi","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089490479","display_name":"Noriko Ban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Ban","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048152463","display_name":"Hidetoshi Kawana","orcid":"https://orcid.org/0009-0008-0391-3565","observed_orcids":["https://orcid.org/0009-0008-0391-3565"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetoshi Kawana","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037848265","display_name":"Daiji Nagayama","orcid":"https://orcid.org/0000-0001-6119-8012","observed_orcids":["https://orcid.org/0000-0001-6119-8012"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daiji Nagayama","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070290343","display_name":"Ayako Nagumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Nagumo","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056777056","display_name":"Atsuhito Saiki","orcid":"https://orcid.org/0000-0003-4009-9386","observed_orcids":["https://orcid.org/0000-0003-4009-9386"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuhito Saiki","raw_affiliation_strings":["Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diabetes, Endocrine and Metabolism, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005795995","display_name":"Takeyoshi Murano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeyoshi Murano","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058147147","display_name":"Hitoshi Watanabe","orcid":"https://orcid.org/0000-0002-9236-7744","observed_orcids":["https://orcid.org/0000-0002-9236-7744"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Watanabe","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103426105","display_name":"Yoh Miyashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoh Miyashita","raw_affiliation_strings":["Department of Internal Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067417455","display_name":"Kohji Shirai","orcid":"https://orcid.org/0000-0003-1189-2668","observed_orcids":["https://orcid.org/0000-0003-1189-2668"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohji Shirai","raw_affiliation_strings":["Department of Internal Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sakura Hospital Medical Center, Toho University, Chiba 285-0841, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103426105"],"corresponding_institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":2.7183,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.89690932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"60","issue":"1","first_page":"78","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.1445000022649765,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-analogs","display_name":"insulin analogues","score":0.6169999837875366},{"id":"https://openalex.org/keywords/postprandial-hyperglycemia","display_name":"postprandial hyperglycemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":1.0},{"id":"https://openalex.org/keywords/cardio-ankle-vascular-index","display_name":"cardio-ankle vascular index","score":0.925000011920929},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/1-5-anhydro-d-glucitol","display_name":"1,5-anhydroglucitol","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ldl-particle-size","display_name":"LDL particle size","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.9304235577583313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8219034671783447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7902497053146362},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.74617999792099},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.6717450618743896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6422045826911926},{"id":"https://openalex.org/C2779908123","wikidata":"https://www.wikidata.org/wiki/Q2754775","display_name":"Insulin aspart","level":4,"score":0.6395329236984253},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5729222893714905},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4611217677593231},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3796761631965637},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.23468297719955444}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007336","descriptor_name":"Insulin, Isophane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061265","descriptor_name":"Biphasic Insulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.metabol.2010.06.001","doi":"https://doi.org/10.1016/j.metabol.2010.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.metabol.2010.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},{"id":"pmid:20667560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20667560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism: clinical and experimental","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W106774261","https://openalex.org/W168362195","https://openalex.org/W1928195896","https://openalex.org/W1936800019","https://openalex.org/W1949064960","https://openalex.org/W1965293684","https://openalex.org/W1977164764","https://openalex.org/W1978600011","https://openalex.org/W1980988474","https://openalex.org/W1981261500","https://openalex.org/W1984542647","https://openalex.org/W1987688627","https://openalex.org/W1990886150","https://openalex.org/W1992021850","https://openalex.org/W1992229080","https://openalex.org/W1994195757","https://openalex.org/W1996201204","https://openalex.org/W1996810831","https://openalex.org/W2001050796","https://openalex.org/W2003414482","https://openalex.org/W2006408342","https://openalex.org/W2009179022","https://openalex.org/W2041389741","https://openalex.org/W2042518766","https://openalex.org/W2043428583","https://openalex.org/W2047095135","https://openalex.org/W2051190392","https://openalex.org/W2054208390","https://openalex.org/W2058313594","https://openalex.org/W2066963386","https://openalex.org/W2067261742","https://openalex.org/W2071870756","https://openalex.org/W2074712105","https://openalex.org/W2076693232","https://openalex.org/W2084032101","https://openalex.org/W2084155565","https://openalex.org/W2089286420","https://openalex.org/W2096230450","https://openalex.org/W2096478205","https://openalex.org/W2109698138","https://openalex.org/W2112655006","https://openalex.org/W2115337518","https://openalex.org/W2120491756","https://openalex.org/W2121788140","https://openalex.org/W2122115743","https://openalex.org/W2123147731","https://openalex.org/W2139171405","https://openalex.org/W2141371969","https://openalex.org/W2141700184","https://openalex.org/W2142478583","https://openalex.org/W2144384987","https://openalex.org/W2159581689","https://openalex.org/W2527659062","https://openalex.org/W3009396807","https://openalex.org/W3015986900","https://openalex.org/W4229984599","https://openalex.org/W4285719527","https://openalex.org/W4300449032","https://openalex.org/W6640389241"],"related_works":["https://openalex.org/W1715392780","https://openalex.org/W2444289409","https://openalex.org/W2098644413","https://openalex.org/W3148163087","https://openalex.org/W2058342653","https://openalex.org/W1551086812","https://openalex.org/W2101930436","https://openalex.org/W1997962812","https://openalex.org/W2034547603","https://openalex.org/W1974949976"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}