{"id":"https://openalex.org/W1976288656","doi":"https://doi.org/10.1016/j.schres.2014.07.038","title":"Efficacy and safety of adjunctive bitopertin (5 and 10mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics \u2014 Results from the phase III DayLyte study","display_name":"Efficacy and safety of adjunctive bitopertin (5 and 10mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics \u2014 Results from the phase III DayLyte study","publication_year":2014,"publication_date":"2014-08-23","ids":{"openalex":"https://openalex.org/W1976288656","doi":"https://doi.org/10.1016/j.schres.2014.07.038","mag":"1976288656"},"language":"en","primary_location":{"id":"doi:10.1016/j.schres.2014.07.038","doi":"https://doi.org/10.1016/j.schres.2014.07.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.schres.2014.07.038","pdf_url":null,"source":{"id":"https://openalex.org/S144105592","display_name":"Schizophrenia Research","issn_l":"0920-9964","issn":["0920-9964","1573-2509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002872855","display_name":"Celso Arango","orcid":"https://orcid.org/0000-0003-3382-4754","observed_orcids":["https://orcid.org/0000-0003-3382-4754"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celso Arango","raw_affiliation_strings":["Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084051141","display_name":"Henry A. Nasrallah","orcid":"https://orcid.org/0000-0002-8567-1094","observed_orcids":["https://orcid.org/0000-0002-8567-1094"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Nasrallah","raw_affiliation_strings":["Saint Louis University School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University School of Medicine, United States","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066795737","display_name":"Stephen M. Lawrie","orcid":"https://orcid.org/0000-0002-2444-5675","observed_orcids":["https://orcid.org/0000-0002-2444-5675"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Lawrie","raw_affiliation_strings":["University of Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046597854","display_name":"Tania Ochi Lohmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tania Ochi Lohmann","raw_affiliation_strings":["F. Hoffmann-La Roche, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012691759","display_name":"Jon Luca Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119458","display_name":"Roche (China)","ror":"https://ror.org/02hv5e369","country_code":"CN","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210119458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jon Luca Zhu","raw_affiliation_strings":["Roche Product Development in Asia Pacific, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Product Development in Asia Pacific, China","institution_ids":["https://openalex.org/I4210119458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050824466","display_name":"George M. Garibaldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"George Garibaldi","raw_affiliation_strings":["F. Hoffmann-La Roche, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783317","display_name":"Alice Wang","orcid":"https://orcid.org/0000-0003-4468-9367","observed_orcids":["https://orcid.org/0000-0003-4468-9367"]},"institutions":[{"id":"https://openalex.org/I4210119458","display_name":"Roche (China)","ror":"https://ror.org/02hv5e369","country_code":"CN","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210119458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Alice Wang","raw_affiliation_strings":["Roche (China) Holding Ltd., China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche (China) Holding Ltd., China","institution_ids":["https://openalex.org/I4210119458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035397814","display_name":"Dragana Bugarski\u2010Kirola","orcid":"https://orcid.org/0009-0007-1733-9640","observed_orcids":["https://orcid.org/0009-0007-1733-9640"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dragana Bugarski-Kirola","raw_affiliation_strings":["F. Hoffmann-La Roche, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":2.0362,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84619692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"158","issue":"1-3","first_page":"e1","last_page":"e1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitopertin","display_name":"bitopertin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7196809649467468},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5977601408958435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5943691730499268},{"id":"https://openalex.org/C3019023267","wikidata":"https://www.wikidata.org/wiki/Q1441305","display_name":"Negative symptom","level":3,"score":0.5802340507507324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4569556713104248},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43396201729774475},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.25854697823524475},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04455047845840454},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.schres.2014.07.038","doi":"https://doi.org/10.1016/j.schres.2014.07.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.schres.2014.07.038","pdf_url":null,"source":{"id":"https://openalex.org/S144105592","display_name":"Schizophrenia Research","issn_l":"0920-9964","issn":["0920-9964","1573-2509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4235423914","https://openalex.org/W2884510193","https://openalex.org/W1986763848","https://openalex.org/W2547186284","https://openalex.org/W2136472480","https://openalex.org/W1963951600","https://openalex.org/W4414934232","https://openalex.org/W7036277899","https://openalex.org/W2100716378","https://openalex.org/W2132980997"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}