{"id":"https://openalex.org/W1976229374","doi":"https://doi.org/10.1007/s004499900157","title":"Development, preparation, and testing of VAQTA\u00ae, a highly purified hepatitis A vaccine","display_name":"Development, preparation, and testing of VAQTA\u00ae, a highly purified hepatitis A vaccine","publication_year":2000,"publication_date":"2000-11-22","ids":{"openalex":"https://openalex.org/W1976229374","doi":"https://doi.org/10.1007/s004499900157","mag":"1976229374"},"language":"en","primary_location":{"id":"doi:10.1007/s004499900157","doi":"https://doi.org/10.1007/s004499900157","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s004499900157","pdf_url":null,"source":{"id":"https://openalex.org/S137312515","display_name":"Bioprocess and Biosystems Engineering","issn_l":"1615-7591","issn":["1615-7591","1615-7605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109248840","display_name":"Anna J. Hagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Hagen","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036398869","display_name":"John G Aunins","orcid":"https://orcid.org/0000-0001-7499-7948","observed_orcids":["https://orcid.org/0000-0001-7499-7948"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Aunins","raw_affiliation_strings":["Department of Cell Culture Development, Merck Research Laboratories, West Point, PA 19486, USA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Culture Development, Merck Research Laboratories, West Point, PA 19486, USA, US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016572554","display_name":"Peter DePhillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. DePhillips","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. B. Oswald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. B. Oswald","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027438376","display_name":"John P. Hennessey","orcid":"https://orcid.org/0000-0003-2252-0421","observed_orcids":["https://orcid.org/0000-0003-2252-0421"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. P. Hennessey Jr.","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029935997","display_name":"John A. Lewis","orcid":"https://orcid.org/0000-0002-3992-7837","observed_orcids":["https://orcid.org/0000-0002-3992-7837"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lewis","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064622230","display_name":"Marcy E. Armstrong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Armstrong","raw_affiliation_strings":["Bioanalytical Development, Merck Manufacturing Division, West Point, PA 19486, USA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalytical Development, Merck Manufacturing Division, West Point, PA 19486, USA, US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Oliver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Oliver","raw_affiliation_strings":["(Current address) MedImmune, Inc., Gaithersburg, MD 20878, USA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Current address) MedImmune, Inc., Gaithersburg, MD 20878, USA, US","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069987522","display_name":"Charles J. Orella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Orella","raw_affiliation_strings":["Chemical Engineering R&D, Merck Research Laboratories, Rahway, NJ 07065-0900, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Engineering R&D, Merck Research Laboratories, Rahway, NJ 07065-0900, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103059978","display_name":"Barry C. Buckland","orcid":"https://orcid.org/0000-0002-5695-8715","observed_orcids":["https://orcid.org/0000-0002-5695-8715"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Buckland","raw_affiliation_strings":["Department of Bioprocess R&D, Merck Research Laboratories, West Point, PA 19486, USA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioprocess R&D, Merck Research Laboratories, West Point, PA 19486, USA, US","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067271698","display_name":"Robert D. Sitrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Sitrin","raw_affiliation_strings":["Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA, , US","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":null,"fwci":0.2427,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62128876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"5","first_page":"439","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.19760000705718994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-a-vaccine","display_name":"hepatitis A vaccine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hepatitis-a-virus","display_name":"hepatitis A virus","score":0.7590000033378601},{"id":"https://openalex.org/keywords/formaldehyde-inactivation","display_name":"formalin inactivation","score":0.906000018119812},{"id":"https://openalex.org/keywords/aluminum-hydroxide-adjuvant","display_name":"aluminum hydroxide adjuvant","score":0.996999979019165},{"id":"https://openalex.org/keywords/vaccine-production","display_name":"vaccine production","score":0.6200000047683716},{"id":"https://openalex.org/keywords/process-scale-up","display_name":"process scale-up","score":0.7879999876022339},{"id":"https://openalex.org/keywords/process-development","display_name":"process development","score":0.7009999752044678},{"id":"https://openalex.org/keywords/in-process-control","display_name":"in-process control","score":0.859000027179718},{"id":"https://openalex.org/keywords/comparability","display_name":"comparability","score":0.4359999895095825},{"id":"https://openalex.org/keywords/product-consistency","display_name":"product consistency","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C2776865271","wikidata":"https://www.wikidata.org/wiki/Q18351432","display_name":"Industrial and production engineering","level":2,"score":0.6253304481506348},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.5216199159622192},{"id":"https://openalex.org/C2987875673","wikidata":"https://www.wikidata.org/wiki/Q187939","display_name":"Manufacturing process","level":2,"score":0.4994466304779053},{"id":"https://openalex.org/C2781037505","wikidata":"https://www.wikidata.org/wiki/Q117749","display_name":"Hepatitis B vaccine","level":5,"score":0.4651789367198944},{"id":"https://openalex.org/C2780799908","wikidata":"https://www.wikidata.org/wiki/Q3553093","display_name":"Hepatitis A vaccine","level":4,"score":0.4139414131641388},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3952707052230835},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.33342522382736206},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.3115033507347107},{"id":"https://openalex.org/C2775876817","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis A","level":3,"score":0.3091945946216583},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.28227484226226807},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.27928608655929565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24075663089752197},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23065736889839172},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19192230701446533},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1854936182498932},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s004499900157","doi":"https://doi.org/10.1007/s004499900157","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s004499900157","pdf_url":null,"source":{"id":"https://openalex.org/S137312515","display_name":"Bioprocess and Biosystems Engineering","issn_l":"1615-7591","issn":["1615-7591","1615-7605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioprocess Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387992613","https://openalex.org/W1608834125","https://openalex.org/W1972730934","https://openalex.org/W2087519811","https://openalex.org/W2487076061","https://openalex.org/W2276439606","https://openalex.org/W4236089917","https://openalex.org/W2324640809","https://openalex.org/W2017934139","https://openalex.org/W1972036402"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}