{"id":"https://openalex.org/W1976213964","doi":"https://doi.org/10.1016/j.ypmed.2011.11.011","title":"Age-associated chronic diseases require age-old medicine: Role of chronic inflammation","display_name":"Age-associated chronic diseases require age-old medicine: Role of chronic inflammation","publication_year":2011,"publication_date":"2011-12-11","ids":{"openalex":"https://openalex.org/W1976213964","doi":"https://doi.org/10.1016/j.ypmed.2011.11.011","mag":"1976213964","pmid":"https://pubmed.ncbi.nlm.nih.gov/22178471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3340492"},"language":"en","primary_location":{"id":"doi:10.1016/j.ypmed.2011.11.011","doi":"https://doi.org/10.1016/j.ypmed.2011.11.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ypmed.2011.11.011","pdf_url":null,"source":{"id":"https://openalex.org/S8081180","display_name":"Preventive Medicine","issn_l":"0091-7435","issn":["0091-7435","1096-0260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preventive Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1976213964"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3340492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050029453","display_name":"Sahdeo Prasad","orcid":"https://orcid.org/0000-0002-3160-6959","observed_orcids":["https://orcid.org/0000-0002-3160-6959"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahdeo Prasad","raw_affiliation_strings":["Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037193058","display_name":"Bokyung Sung","orcid":"https://orcid.org/0009-0001-2423-3613","observed_orcids":["https://orcid.org/0009-0001-2423-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bokyung Sung","raw_affiliation_strings":["Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048675624","display_name":"Bharat Bhushan Aggarwal","orcid":"https://orcid.org/0000-0003-3534-2898","observed_orcids":["https://orcid.org/0000-0003-3534-2898"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bharat B. Aggarwal","raw_affiliation_strings":["Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","Experimental Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Experimental Therapeutics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048675624"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":1.2975,"has_fulltext":false,"cited_by_count":320,"citation_normalized_percentile":{"value":0.73563218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"54","issue":null,"first_page":"S29","last_page":"S37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.11980000138282776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8640000224113464},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.41100001335144043},{"id":"https://openalex.org/keywords/lifestyle","display_name":"lifestyle","score":0.652999997138977},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nutrition","display_name":"nutrition","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tobacco-use","display_name":"tobacco use","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8370000123977661},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9770171642303467},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7007128000259399},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.5332455635070801},{"id":"https://openalex.org/C52207206","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Preventive healthcare","level":3,"score":0.4309914708137512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3631601929664612},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3527659773826599},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3340770900249481},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18797919154167175},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.1218961775302887}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040242","descriptor_name":"Risk Reduction Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ypmed.2011.11.011","doi":"https://doi.org/10.1016/j.ypmed.2011.11.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ypmed.2011.11.011","pdf_url":null,"source":{"id":"https://openalex.org/S8081180","display_name":"Preventive Medicine","issn_l":"0091-7435","issn":["0091-7435","1096-0260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preventive Medicine","raw_type":"journal-article"},{"id":"pmid:22178471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22178471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preventive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2635028","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3340492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3340492","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3340492/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prev Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2635028","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3340492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5472537264","display_name":"Mechanisms of Symptoms of Multiple Myeloma and Its Therapy","funder_award_id":"P01CA124787","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G592975789","display_name":null,"funder_award_id":"CA-124787-01A2","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W156974138","https://openalex.org/W1483930211","https://openalex.org/W1501881225","https://openalex.org/W1502098090","https://openalex.org/W1513656548","https://openalex.org/W1563850712","https://openalex.org/W1580962701","https://openalex.org/W1596602458","https://openalex.org/W1633340712","https://openalex.org/W1639924204","https://openalex.org/W1749022239","https://openalex.org/W1796979535","https://openalex.org/W1826815948","https://openalex.org/W1919902298","https://openalex.org/W1942251818","https://openalex.org/W1964286374","https://openalex.org/W1964698686","https://openalex.org/W1971629816","https://openalex.org/W1974693938","https://openalex.org/W1976148924","https://openalex.org/W1976992154","https://openalex.org/W1977818137","https://openalex.org/W1978047924","https://openalex.org/W1980237439","https://openalex.org/W1987902578","https://openalex.org/W1991134124","https://openalex.org/W1992093441","https://openalex.org/W1997546288","https://openalex.org/W1999112733","https://openalex.org/W2003856886","https://openalex.org/W2006694101","https://openalex.org/W2006927975","https://openalex.org/W2012644261","https://openalex.org/W2016413991","https://openalex.org/W2018135697","https://openalex.org/W2018267275","https://openalex.org/W2019222409","https://openalex.org/W2021598287","https://openalex.org/W2021878174","https://openalex.org/W2030631780","https://openalex.org/W2030634993","https://openalex.org/W2030865745","https://openalex.org/W2034269086","https://openalex.org/W2035215331","https://openalex.org/W2035954299","https://openalex.org/W2040433877","https://openalex.org/W2041801015","https://openalex.org/W2043557683","https://openalex.org/W2043620261","https://openalex.org/W2045738168","https://openalex.org/W2047457369","https://openalex.org/W2048144074","https://openalex.org/W2050183249","https://openalex.org/W2050206306","https://openalex.org/W2050991210","https://openalex.org/W2051394232","https://openalex.org/W2051455866","https://openalex.org/W2052977964","https://openalex.org/W2053836644","https://openalex.org/W2054607022","https://openalex.org/W2056126636","https://openalex.org/W2057003380","https://openalex.org/W2059287377","https://openalex.org/W2069546816","https://openalex.org/W2069920032","https://openalex.org/W2070498132","https://openalex.org/W2070922892","https://openalex.org/W2071890516","https://openalex.org/W2072423141","https://openalex.org/W2072870301","https://openalex.org/W2073851843","https://openalex.org/W2074407690","https://openalex.org/W2074599278","https://openalex.org/W2076429988","https://openalex.org/W2076691278","https://openalex.org/W2080447135","https://openalex.org/W2081093364","https://openalex.org/W2081265477","https://openalex.org/W2086308144","https://openalex.org/W2088094960","https://openalex.org/W2089343966","https://openalex.org/W2089372467","https://openalex.org/W2094308301","https://openalex.org/W2097634036","https://openalex.org/W2102069294","https://openalex.org/W2103411973","https://openalex.org/W2103422355","https://openalex.org/W2106607972","https://openalex.org/W2111522975","https://openalex.org/W2111575055","https://openalex.org/W2112549281","https://openalex.org/W2115338196","https://openalex.org/W2118278569","https://openalex.org/W2121666713","https://openalex.org/W2123839614","https://openalex.org/W2124043243","https://openalex.org/W2129363220","https://openalex.org/W2132741387","https://openalex.org/W2133481218","https://openalex.org/W2136700586","https://openalex.org/W2137958975","https://openalex.org/W2142147434","https://openalex.org/W2147052750","https://openalex.org/W2156156861","https://openalex.org/W2156280702","https://openalex.org/W2156520097","https://openalex.org/W2158873788","https://openalex.org/W2160770127","https://openalex.org/W2160770872","https://openalex.org/W2161028038","https://openalex.org/W2161888687","https://openalex.org/W2167243724","https://openalex.org/W2168332555","https://openalex.org/W2169085459","https://openalex.org/W2169238639","https://openalex.org/W2170476987","https://openalex.org/W2170596177","https://openalex.org/W2174827795","https://openalex.org/W2191671914","https://openalex.org/W2409292871","https://openalex.org/W2410718987","https://openalex.org/W2739174192","https://openalex.org/W6633710690","https://openalex.org/W6638387442","https://openalex.org/W6678664832","https://openalex.org/W6714188210"],"related_works":["https://openalex.org/W2416156228","https://openalex.org/W3177635763","https://openalex.org/W4247268410","https://openalex.org/W4315796630","https://openalex.org/W2130063988","https://openalex.org/W4319073289","https://openalex.org/W2993908729","https://openalex.org/W2479537259","https://openalex.org/W4406613492","https://openalex.org/W2142429476"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":42},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
